DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and CG8243

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	84/314 - (26%)
Similarity:	125/314 - (39%)	Gaps:	97/314 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   688 IESSKTKQAT-------STDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHR 745
            :.||...|.|       .|.|..||    |...|.:||||.|..|.|||.|||:.:||.|:|:||
  Fly     1 MSSSNAGQRTKLIQEKCQTLLTQML----RDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHR 61

  Fly   746 NLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRV-KPTSQASREDKERWVRSKY 809
            |||.|||:|:|:.||.|....:..:..:|||.|.:|:|:...... :|.:..:.|:   ::|:||
  Fly    62 NLGVHISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALEN---FIRAKY 123

  Fly   810 EAKEFLTPLGNGSSAHPSPSP-----GQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRT 869
            |.|::|      :.....|||     .:::.|.:.|...|.
  Fly   124 EHKKYL------AREWVPPSPPKVDWAKEIDEELERQKRKK------------------------ 158

  Fly   870 PLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAP 934
                                    |.|  :.:..|..|..|......:...::|:|...|.:|||
  Fly   159 ------------------------KST--QAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAP 197

  Fly   935 AP---PTNGGIPAPQYNVEDTTALVEL------------LEGLGCPEAAPLTAS 973
            .|   |...|..:|:     ||..|:|            |.||..| ..|:.|:
  Fly   198 LPKPKPNQVGGCSPK-----TTQRVQLNSSGVSSAGESDLLGLSSP-TKPIVAT 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	47/116 (41%)
		ANK	<834..907	CDD:238125	6/72 (8%)
		ANK repeat	834..866	CDD:293786	3/31 (10%)
		Ank_5	859..907	CDD:290568	3/47 (6%)
		ANK repeat	868..897	CDD:293786	1/28 (4%)
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	49/126 (39%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	79/295 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740