DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and RhoGAP15B

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	163/908 - (17%)
Similarity:	281/908 - (30%)	Gaps:	321/908 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 LSQRLPLP------PQVQPA--------RPTTPQGN-------RLGLAPYQAPTNGQRGQQQLPL 344
            :.|..|:|      |:::||        ||.:|..|       :|.:....  .:|...:::||
  Fly     1 MEQARPVPAPRRLYPELRPANYENIEIRRPNSPSNNINHNNIKKLNINAEN--LHGNCAEKKLP- 62

  Fly   345 RMSADFAQAEQKLWSLQAASSSTINENNNITK---YNPGAANSLQGDCSQVQLRDPRDLAPPPGK 406
                  :..:.||         .:.|||:.::   |.|.|..::|..........||...||.|:
  Fly    63 ------SSGQNKL---------ILQENNSDSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGE 112

  Fly   407 ---ELPTP---------TSTPTTSRKS-----RRRSNLFIPSSSK------KADKEKEPKSSELG 448
               ..|.|         .:.|....|.     .:||::....|:.      |||:::|  .|...
  Fly   113 PEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDRE--GSRYA 175

  Fly   449 SGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCD-----------DGRLTYHPSL----------- 491
            |..|:...:.     |.....|.....||...|           :|   :||..
  Fly   176 SNASLDCSES-----SHSGKFKSQSPGYVDAVDSSIPQSDHPDPNG---HHPQAESSSAEQSSGS 232

  Fly   492 HDYMDD------------VHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTL 544
            .|..||            :.|:.|. :.:|.|..|.|.|..::..:::...|::.|:..|:....
  Fly   233 QDGDDDNNLLRSLGTTSKLLGEAIG-ERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHA 296

  Fly   545 SDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAG---------------------GEPLKSNS-- 586
            |...|.......|:.|..     :|.|....|:|                     ..||..|.
  Fly   297 SKRFGSNFSLGRNKDKAD-----IGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGL 356

  Fly   587 --------------------SQQTSG--------------DEGIAMSNSNSQTFIAGEVANAGNK 617
                                .|:..|              ||.:....|.|.:.::..:|....:
  Fly   357 PDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQ 421

  Fly   618 LEAQTPNVKKRHRRMKSSSVKANEADDN-----DGYEFYIVSLDSKQWHFEAANSEERDEWVAAV 677
            |      |:.|::|..|||  ::..|::     ..:....:|...:|:..:|..        ..|
  Fly   422 L------VQLRNQRQLSSS--SSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQ--------PPV 470

  Fly   678 EQEIFKSLQSIESSK----TKQATSTDLAAMLAIRQR---VPGNGFCVDCGAPNPEWASLNLGVL 735
            .|:..|:.:.||..:    :.|....:.||..|.|:.   :.......:...|.||
  Fly   471 RQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPE--------- 526

  Fly   736 MCIECSGVHRNLGSHISKVRSLGLDDW----------------------PSPHLSVMLAIGNSLA 778
                               ||   |.|                      |.|..:...|....|.
  Fly   527 -------------------RS---DSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLF 569

  Fly   779 NSVWESNTRQRVKPTSQASREDKERWVRSKYE-----------------AKEFLTPLGNGSS--A 824
            ......::|..|...:|.:.:.:...:....|                 .:|| .||.:..|  |
  Fly   570 EMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEF-DPLSSKCSTLA 633

  Fly   825 HPSPSPGQQLIEAVIRAD----IKSIVSILANCPSE---VTNANVSARDVRTPLLLACAIGNLAI 882
            ..:.|....|:|.::..|    :|:....::.|.||   .|:|..|.:..:..::       ...
  Fly   634 RSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIV-------HQN 691

  Fly   883 AQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTT---IPAPA--------- 935
            |:||..:..|:..:|.| |.....:|..:|...|......|:|....|   :|..|
  Fly   692 ARLLSDSMENMLDSDQE-RAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNT 755

  Fly   936 ----PPTNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGV 994
                ||..|..| |.|           ||.:|    ....|:|. ...|.|:|:.:.::::.:
  Fly   756 SKTTPPIEGDSP-PTY-----------LEAIG----GSKDAAGN-QENRSTIGSRFRQTINAI 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	54/330 (16%)
		PH	454..>521	CDD:278594	18/100 (18%)
		ArfGap	702..818	CDD:279720	21/157 (13%)
		ANK	<834..907	CDD:238125	17/79 (22%)
		ANK repeat	834..866	CDD:293786	10/38 (26%)
		Ank_5	859..907	CDD:290568	9/47 (19%)
		ANK repeat	868..897	CDD:293786	4/28 (14%)
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900