DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and AGFG2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_005250363.1	Gene:	AGFG2 / 3268	HGNCID:	5177	Length:	492	Species:	Homo sapiens

Alignment Length:	321	Identity:	63/321 - (19%)
Similarity:	112/321 - (34%)	Gaps:	101/321 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   713 GNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLG-SHISKVRSLGLDDWPSPHLSVMLAIGNS 776
            ||..|.:|......:..:.:|..:|..|||:.|.|. .|  :|:|:.:..:..|.:..:.:.||.
Human    43 GNRHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPH--RVKSISMTTFTEPEVVFLQSRGNE 105

  Fly   777 LANSVWES--NTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVI 839
            :...:|..  :.|..:.|.|:..::.|| :::.|||.|.:..|            |.|
Human   106 VCRKIWLGLFDARTSLVPDSRDPQKVKE-FLQEKYEKKRWYVP------------PDQ------- 150

  Fly   840 RADIKSIVSILANCPSEVTNANVSARDVRT-------PLLLACAIGNLAIAQLLIWNGANIKHTD 897
               :|.......:..:.|..:....:.:||       .|.:|.:..:..::|
Human   151 ---VKGPTYTKGSASTPVQGSIPEGKPLRTLLGDPAPSLSVAASTSSQPVSQ------------- 199

  Fly   898 HEGRTCLAYARAAQSLATA----KSIKAAA----AAQAGTTIPAP--AP------------PTNG 940
                   ::||.:|:.:|.    .|:|.|:    |...|....||  ||            |:.|
Human   200 -------SHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMAPAFAAFPAFGGQTPSQG 257

  Fly   941 GI-------------------PAPQ--YNVEDTTALVELLE---GLGCPEAAPLTASGTLP 977
            |.                   ||.|  :..:.|.|...:|.   ..|..:..|..|:...|
Human   258 GFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAASRMLTESYSFGSSQGTPFGATPLAP 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	27/107 (25%)
		ANK	<834..907	CDD:238125	7/79 (9%)
		ANK repeat	834..866	CDD:293786	2/31 (6%)
		Ank_5	859..907	CDD:290568	5/54 (9%)
		ANK repeat	868..897	CDD:293786	5/35 (14%)
AGFG2	XP_005250363.1	ArfGap	40..147	CDD:295313	27/106 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900