DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Acap3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001382677.1	Gene:	Acap3 / 313772	RGDID:	1310711	Length:	833	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	149/734 - (20%)
Similarity:	227/734 - (30%)	Gaps:	342/734 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 PTTSRKSRRRSNLFIPSSSKKADKEK-----------------EPKSSELGSGRSIPIKQGYLYK 462
            |...:.:.....|.|.|:.:|.:.|:                 |||........|..:.:|||:|
  Rat   213 PYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEFDVDAPSGVVMEGYLFK 277

  Fly   463 RSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNS 527
            |:|.:. |.|.:::.:: .:.:|.|...|.|
  Rat   278 RASNAF-KTWNRRWFSI-QNSQLVYQKKLKD---------------------------------- 306

  Fly   528 ALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSG 592
                                  .||:..|:.|..|.|                |.:
  Rat   307 ----------------------ALTVVVDDLRLCSVK----------------PCE--------- 324

  Fly   593 DEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDS 657
                                           ::::|                   :.|.:|| .:
  Rat   325 -------------------------------DIERR-------------------FCFEVVS-PT 338

  Fly   658 KQWHFEAANSEERDEWVAAVEQEIFK--------------------SLQSIESSKTKQATSTDLA 702
            |....:|.:.:.|..||.||:..|..                    |..||:|:...:.......
  Rat   339 KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGE 403

  Fly   703 AMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHL 767
            ::|...|.|.||..|.|||.|:|.|||:|||||:||||||:||:||.|.||||||.||.|....|
  Rat   404 SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELL 468

  Fly   768 SVMLAIGNSLANSVWESNTRQR--VKPTSQASREDKERWVRSKYEAKEFLTPLGNG--------- 821
            .:|..:||:..|.::|:.....  .|||:.:||:|||.|::.||..|:||..|.:.
  Rat   469 KLMCELGNNTMNQIYEAQCEGPGIRKPTASSSRQDKEAWIKDKYVEKKFLRKLTSAPVREPPRRW 533

  Fly   822 ---------SSAH--------------PSPS---------------------------------- 829
                     ||.|              ||.:
  Rat   534 RAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAGTMERKFRRDSLFCPDELDSLFSYFDAGA 598

  Fly   830 ----------------------------------------------------------------- 829

  Rat   599 AGAGPRSLSSDSGLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRE 663

  Fly   830 --PGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGAN 892
              ||....:|....|:.::.:.||: .:||..|: :|.:.:|||:.|...|:|.:.:.|:.|||:
  Rat   664 LHPGLLAHQAARTRDLPALAAALAH-GAEVNWAD-TADEGKTPLVQAVLGGSLIVCEFLLQNGAD 726

  Fly   893 IKHTDHEGR--------------TCLAYARAAQSLATAK--------SIKAA---------AAAQ 926
            :...|..||              .||...|.|...|..:        :::||         .|..
  Rat   727 VNQRDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARM 791

  Fly   927 AGTTIPAPAPPTNGGIPAP 945
            |.....|.|||   |.|.|
  Rat   792 AEEMREAEAPP---GQPGP 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	33/254 (13%)
		PH	454..>521	CDD:278594	12/66 (18%)
		ArfGap	702..818	CDD:279720	59/117 (50%)
		ANK	<834..907	CDD:238125	23/86 (27%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	17/61 (28%)
		ANK repeat	868..897	CDD:293786	10/28 (36%)
Acap3	NP_001382677.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820