Protein Alignment CenG1A and Acap3

DIOPT Version :10

• Sequence 1: NP_723849.1
• Gene: CenG1A / 34803
• FlyBaseID: FBgn0028509
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_001382677.1
• Gene: Acap3 / 313772
• RGDID: 1310711
• Length: 833
• Species: Rattus norvegicus
• Alignment Length: 734
• Identity: 149/734 - (20%)
• Similarity: 227/734 - (30%)
• Gaps: 342/734 - (46%)

  Fly   415 PTTSRKSRRRSNLFIPSSSKKADKEK-----------------EPKSSELGSGRSIPIKQGYLYK 462
            |...:.:.....|.|.|:.:|.:.|:                 |||........|..:.:|||:|
  Rat   213 PYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEFDVDAPSGVVMEGYLFK 277

  Fly   463 RSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNS 527
            |:|.:. |.|.:::.:: .:.:|.|...|.|
  Rat   278 RASNAF-KTWNRRWFSI-QNSQLVYQKKLKD---------------------------------- 306

  Fly   528 ALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSG 592
                                  .||:..|:.|..|.|                |.:
  Rat   307 ----------------------ALTVVVDDLRLCSVK----------------PCE--------- 324

  Fly   593 DEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDS 657
                                           ::::|                   :.|.:|| .:
  Rat   325 -------------------------------DIERR-------------------FCFEVVS-PT 338

  Fly   658 KQWHFEAANSEERDEWVAAVEQEIFK--------------------SLQSIESSKTKQATSTDLA 702
            |....:|.:.:.|..||.||:..|..                    |..||:|:...:.......
  Rat   339 KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGE 403

  Fly   703 AMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHL 767
            ::|...|.|.||..|.|||.|:|.|||:|||||:||||||:||:||.|.||||||.||.|....|
  Rat   404 SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELL 468

  Fly   768 SVMLAIGNSLANSVWESNTRQR--VKPTSQASREDKERWVRSKYEAKEFLTPLGNG--------- 821
            .:|..:||:..|.::|:.....  .|||:.:||:|||.|::.||..|:||..|.:.
  Rat   469 KLMCELGNNTMNQIYEAQCEGPGIRKPTASSSRQDKEAWIKDKYVEKKFLRKLTSAPVREPPRRW 533

  Fly   822 ---------SSAH--------------PSPS---------------------------------- 829
                     ||.|              ||.:
  Rat   534 RAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAGTMERKFRRDSLFCPDELDSLFSYFDAGA 598

  Fly   830 ----------------------------------------------------------------- 829
                                                                             
  Rat   599 AGAGPRSLSSDSGLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRE 663

  Fly   830 --PGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGAN 892
              ||....:|....|:.::.:.||: .:||..|: :|.:.:|||:.|...|:|.:.:.|:.|||:
  Rat   664 LHPGLLAHQAARTRDLPALAAALAH-GAEVNWAD-TADEGKTPLVQAVLGGSLIVCEFLLQNGAD 726

  Fly   893 IKHTDHEGR--------------TCLAYARAAQSLATAK--------SIKAA---------AAAQ 926
            :...|..||              .||...|.|...|..:        :::||         .|..
  Rat   727 VNQRDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARM 791

  Fly   927 AGTTIPAPAPPTNGGIPAP 945
            |.....|.|||   |.|.|
  Rat   792 AEEMREAEAPP---GQPGP 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<2..41	CDD:461363
		Centaurin_gamma	143..300	CDD:133303
		PH_AGAP	451..686	CDD:241281	33/254 (13%)
		ArfGap_AGAP	702..810	CDD:350065	55/109 (50%)
		ANKYR	<834..>907	CDD:440430	23/86 (27%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		ANK repeat	868..897	CDD:293786	10/28 (36%)
Acap3	NP_001382677.1	BAR_ACAP3	16..215	CDD:153321	1/1 (100%)
		PH_ACAP	271..367	CDD:270070	31/229 (14%)
		ArfGap_ACAP3	403..518	CDD:350075	57/114 (50%)
		ANKYR	<669..>786	CDD:440430	28/118 (24%)
		ANK repeat	700..731	CDD:293786	10/30 (33%)
		ANK repeat	733..764	CDD:293786	7/30 (23%)