DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and Appl1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_038951064.1	Gene:	Appl1 / 290537	RGDID:	1309388	Length:	720	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	135/677 - (19%)
Similarity:	211/677 - (31%)	Gaps:	244/677 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 QQQLPLR-----MSA---DFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLR 395
            :|:.||.     ||:   .|::...:|.|..|..|:.:             |:::....||.:.|
  Rat    70 KQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQL-------------ADAMMFPISQFKER 121

  Fly   396 DPRDLAPPPGKELPTPTSTP------TTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIP 454
            |.:::...  ||:....|..      ..||.|::|.|          ||.|...:.::.:.|.
  Rat   122 DLKEILTL--KEVFQIASNDHDAAINRYSRLSKKREN----------DKVKYEVTEDVYTSRK-- 172

  Fly   455 IKQGYLYKRSSKSLNK-EWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPR 518
             ||.........:||. ::|||...|                      |..|.|:..::...| .
  Rat   173 -KQHQTMMHYFCALNTLQYKKKIALL----------------------EPLLGYMQAQISFFK-M 213

  Fly   519 GSKSIITNSALTSSLMANGQRAQN----------TLSDGIGCLTLAKDN-------------QRK 560
            ||:::  |..|...|...|...||          |:...|..|.:|.|.             .|.
  Rat   214 GSENL--NGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPVNRN 276

  Fly   561 LSEKLSLLGA----GSIAA--------GAGGEPLKSNSSQQTSGD--EGIAMSNSNSQTFIAGEV 611
            |:.|...|.|    |.:::        ..||     |...|..||  .|:||...|
  Rat   277 LTRKAGYLNARNKTGLVSSTWDRQFYFTQGG-----NLMSQARGDVAGGLAMDIDN--------- 327

  Fly   612 ANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWH-FEAANSEERDEWVA 675
                                   .||.|.:.:|. .|.|.|.|.|.|:.. .:|.:.::.:||:.
  Rat   328 -----------------------CSVMAVDCEDR-RYCFQITSFDGKKSSILQAESKKDHEEWIC 368

  Fly   676 A---VEQEIFKSLQSIE-SSKTKQATSTDLAAMLAIRQR----VPGNGFCVDCGAPNPEWASLNL 732
            .   :.::|:.|....| :::..|:....:....:.:||    .||       |...|..|..:
  Rat   369 TINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPG-------GQSRPPTARTS- 425

  Fly   733 GVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQAS 797
                   .||   :|||..:.:.:|.||...:|...:..    .:.:.|.|....| .|...|..
  Rat   426 -------SSG---SLGSESTNLAALSLDSLVAPDTPIQF----DIISPVCEDQPGQ-AKAFGQGG 475

  Fly   798 REDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANV 862
            |.               ..|.|....:..|.:.|:                         |:.||
  Rat   476 RR---------------TNPFGESGGSTKSETEGR-------------------------TDCNV 500

  Fly   863 SARDVRTPLLLACAIGNLAIAQLLI---WNGANIKHTDHEG------RTCLAYARAAQS------ 912
            ..|          .|.|..:.||.|   .....:|..||..      |..|| |||..:
  Rat   501 HPR----------VISNSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILA-ARAIHNIFRMTE 554

  Fly   913 ---LATAKSIKAAAAAQAGTTIPAPAP 936
               |.|...:|........|.:..|.|
  Rat   555 SHLLVTCDCLKLIDPQTQVTRLTFPLP 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	57/276 (21%)
		PH	454..>521	CDD:278594	13/67 (19%)
		ArfGap	702..818	CDD:279720	22/119 (18%)
		ANK	<834..907	CDD:238125	15/81 (19%)
		ANK repeat	834..866	CDD:293786	3/31 (10%)
		Ank_5	859..907	CDD:290568	14/56 (25%)
		ANK repeat	868..897	CDD:293786	6/31 (19%)
Appl1	XP_038951064.1	BAR_APPL1	20..234	CDD:153315	45/216 (21%)
		BAR-PH_APPL	252..376	CDD:270067	32/161 (20%)
		PTB_APPL	506..637	CDD:269980	19/77 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910