DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and cnt6

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_594153.1	Gene:	cnt6 / 2542074	PomBaseID:	SPAC26A3.10	Length:	923	Species:	Schizosaccharomyces pombe

Alignment Length:	950	Identity:	195/950 - (20%)
Similarity:	321/950 - (33%)	Gaps:	278/950 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 VGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVI 212
            |..|::| |.:..|.....:::..|...|:. .::.:|..|...|       |:..|...:| ..
pombe    13 VSKLDNG-STISFRAREDGFLESISSSSGKL-VDMVLDSTSKECL-------PKFSFQNKLD-FY 67

  Fly   213 FVFS-----------------LENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISER---- 256
            |:||                 .|:..||::.:....|.|...:...:..|.:...:|.:.|
pombe    68 FLFSDRVLQLQKERKVLVLIHCESLQSFDSFFAQKLKYADLISSDNVHEIFLPDSNAANIRYHWE 132

  Fly   257 --------------NPRVI------DDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKIL 301
                          |...|      |.|..|     :.:.||| |.:..|.:::..|....|::.
pombe   133 WSPPSGKLLEYECKNYSCIAVYSTEDCTLER-----ISKFSYY-TVSRCGDSMDDTFFSESQRVT 191

  Fly   302 SQRLPLPPQVQPARPTTPQG-NRLGLAPYQA---PTNGQRG----------QQQLPL------RM 346
            |. |.....||...|.:|:. ..|.|...:.   |.|.:.|          :|:..|      ::
pombe   192 SP-LTTSQTVQTQPPQSPEAKTELSLINTKTVIFPENYEDGPSFRSMLHELEQKSSLMKYYCKKI 255

  Fly   347 SADFAQAEQKLWSLQAA---SSSTINENNNITKYNPG--------AANSLQGDCSQVQLRDPRDL 400
            .....|......:.|.|   .|.|::|.:|.|..|..        .|..:.....|....|..:|
pombe   256 MKRIVQLSDAYDASQVAVMKLSETLSEASNSTSMNMDILLDSYLTKAMDIHATFIQKLNYDLINL 320

  Fly   401 APPPGKELPTPTSTPTTSRKSR--RRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKR 463
            ...|...:.:....|...|:..  .:|..|..|.|:....:|:.|..:
pombe   321 LYEPFHNIYSSFIKPIDDRRLEFDEQSKSFYGSLSRYLSAKKDKKGGD----------------- 368

  Fly   464 SSKSLNKEWK---KKYVTLCDDGRLTYHPSLHD--YMDDVHGKEIPLQYVTVKVPGQKPRGSKSI 523
             ||...||..   ::|...|      :...|||  .::|::|  |.|||.        .|....|
pombe   369 -SKFFQKEKTFALQRYDYYC------FMQDLHDGSIINDING--IFLQYF--------HRQYDHI 416

  Fly   524 ITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKL--SEKLSLLGAGSIAAGAGGEPLK--- 583
            ...|.|.:|::.|.|:. |...:.....|..:|..|::  |:.:...|.....|.....|:.
pombe   417 ALFSNLMNSVLPNLQQL-NLKLEKTKWSTTRRDKGREMHRSQVIQTSGRPKSMAPPSPSPISPSF 480

  Fly   584 ---------SNSSQQTSGDEGIAMSNSNSQTFIAGE-VANAGN------------------KLEA 620
                     .|.....|.|:  ....||..|.|.|: ::|.|:                  :|..
pombe   481 PLHEIQSPMPNRRMAASADD--ISQTSNFTTEIKGKCISNGGSASPDKIFKEGLLLVFGATELGT 543

  Fly   621 QTPNVKK----RH--------------------RRMKSSSVKANEAD----DNDGYEFYIVSLDS 657
            ....|.|    :|                    ..:.|.|:|...||    ....:.|.:|:...
pombe   544 DLAMVSKAAWHKHWIVVENGSLWEYANWKDSVKSNVSSISLKHASADKVRKQGRRFCFEVVTPKL 608

  Fly   658 KQWHFEAANSEERDEWVAAV--------------------------------------------- 677
            |:. ::|.::||.|.|:.|:
pombe   609 KRL-YQATSAEEMDSWIEAICEAAKISSFQLSRVATPLSASVRRPSKVFPLFSTSFETTPISRKL 672

  Fly   678 ----------------EQEIFKSLQS----IESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGA 722
                            .|:.|:|..|    :|..:...|::.....||  |:....|..|.|||:
pombe   673 SGSGIKKAFSRKGSWNLQQFFRSDNSGTMHMEQLERYHASANIFIQML--RKTDVSNSVCADCGS 735

  Fly   723 -PNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESN- 785
             .:..|.|:|:.|::||||||:||:||:||||.|||.||........::..|||:..|.|:|..
pombe   736 VKDVTWCSINIPVVLCIECSGIHRSLGTHISKTRSLLLDSLSQQSKVLLCKIGNAAVNRVYEKGL 800

  Fly   786 TRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSIL 850
            :...:||..:.:.:.|..:.:.||....|:...|..:.|        .|:|.:.:..|..|:..|
pombe   801 SNPSLKPKPEHNAQVKLAFAQKKYVEHAFIDFAGVDADA--------TLLEGLEQNKISKILLGL 857

  Fly   851 ANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNG 890
            |..|:...|..|..:.|...      ...|.:.:||..||
pombe   858 AAKPNFEENGVVFLKAVTRD------TSKLHLLELLFMNG 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	36/192 (19%)
		RAS	144..295	CDD:214541	35/187 (19%)
		PH_AGAP	451..686	CDD:241281	61/361 (17%)
		PH	454..>521	CDD:278594	16/71 (23%)
		ArfGap	702..818	CDD:279720	43/117 (37%)
		ANK	<834..907	CDD:238125	14/56 (25%)
		ANK repeat	834..866	CDD:293786	9/31 (29%)
		Ank_5	859..907	CDD:290568	7/31 (23%)
		ANK repeat	868..897	CDD:293786	4/22 (18%)
cnt6	NP_594153.1	BAR_ArfGAP_fungi	236..430	CDD:153292	44/227 (19%)
		PH	527..632	CDD:214574	18/105 (17%)
		PH	550..632	CDD:278594	16/82 (20%)
		ArfGap	717..837	CDD:214518	44/121 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9294
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840