DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and glo3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_594843.2	Gene:	glo3 / 2541825	PomBaseID:	SPAC22E12.17c	Length:	483	Species:	Schizosaccharomyces pombe

Alignment Length:	350	Identity:	83/350 - (23%)
Similarity:	141/350 - (40%)	Gaps:	76/350 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   674 VAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCI 738
            :.|.::|..|.|.|:.|.:                    .|..|.||||.||.|:|...|:.:|:
pombe     1 MTATKEESQKLLTSLRSQR--------------------DNKVCFDCGAKNPTWSSTTFGIYLCL 45

  Fly   739 ECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWES-------NTRQ-RVKPTSQ 795
            :||..|||:|.|||.|||..||.|....|.||...||..|.:.::.       |::. |:|.:|:
pombe    46 DCSAAHRNMGVHISFVRSTVLDSWTYAQLRVMRVGGNENARNYFKRHGGVSLLNSKDCRLKYSSK 110

  Fly   796 ASRE--DKERWVRSKYEAK-------EFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSI----- 846
            .:::  :|.:.:..:.||.       :||:....||||..:.:.......|..:|.:|..
pombe   111 TAKQYLEKLKSLAVEDEANYPDILDMDFLSNTHEGSSAADTTNEDDDFFSAWDKASVKKSDDNLD 175

  Fly   847 -VSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAA 910
             .:.||:..|.|.   |.:.:...|:::.                        |.:|.::.....
pombe   176 DKTDLASTSSSVV---VESGEKDEPVVVT------------------------EEKTMVSPPSRP 213

  Fly   911 QSLATAKSIKAAAAAQAGTTIPAPAPPTNG--GIPAPQ-YNVEDTTALV---ELLEGLGCPEAAP 969
            .|.:|.||..::.::.....|.|.:.||..  |...|| ..::...|.:   |..:.:...|:||
pombe   214 DSTSTTKSKTSSISSARARPIRASSRPTASKLGASRPQKLGIKKANADIDFDEFEKAVLSSESAP 278

  Fly   970 LTASGTLPRRRDTLGTPYEKSVSGV 994
            ......:..:..|:.|..:..|..|
pombe   279 TKKPAAVASKESTVDTLVDNGVEEV 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	3/11 (27%)
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	42/132 (32%)
		ANK	<834..907	CDD:238125	11/78 (14%)
		ANK repeat	834..866	CDD:293786	8/37 (22%)
		Ank_5	859..907	CDD:290568	4/47 (9%)
		ANK repeat	868..897	CDD:293786	1/28 (4%)
glo3	NP_594843.2	COG5347	2..348	CDD:227651	82/348 (24%)
glo3	NP_594843.2	ArfGap	12..128	CDD:214518	41/135 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900