DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and cnt5

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_595897.1	Gene:	cnt5 / 2539865	PomBaseID:	SPBC17G9.08c	Length:	870	Species:	Schizosaccharomyces pombe

Alignment Length:	934	Identity:	201/934 - (21%)
Similarity:	345/934 - (36%)	Gaps:	265/934 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 GSLNSGKSALVHRYLTGSYMQEESPEGGRF----KKEVFIDGQSYLLLIRDEGGAPEMQFAGWVD 209
            ||.|...|..||..       .:|||..::    |....|:   ::.|..:||...:::..   |
pombe    21 GSANDNASLQVHNV-------SKSPEYSKYSYSRKNNEPIE---FIQLREEEGPIVKVEEE---D 72

  Fly   210 AVIFVFSLE---NEG-----SFNTVY------------NYYTKMAHFRNGQEIPMILVGTQDAIS 254
            .:...|.||   .||     :...||            ..::..|:|:|..::  .|:|..:..|
pombe    73 GLTLRFQLEFHAQEGKRDVTNLTCVYGTSPQQLDRLITREFSSDANFQNNHQV--FLIGNIEFHS 135

  Fly   255 ERNPRVID---------------------------DTRARKLASDLKRCSYYET--------CAT 284
            ..|.:.|:                           |.|...|. .||...:|.|        ...
pombe   136 NENSKKIEWTWSNQSLHTLYFRNGGSPIYLCFAEYDKRLNCLV-PLKTFQFYVTESDQDSTPATP 199

  Fly   285 YGLNVERVFQDACQKILSQRLPL-----------PPQVQP-AR---PTTPQGN---RLGLAPYQA 331
            :.:.:....:.|....:|...||           ||...| ||   .|.|:..   |..:..|:.
pombe   200 FPMPMHLAEETATSPEISDAPPLSGNVDPLPINSPPLTNPVARDIDQTEPEDGPLFRATILNYER 264

  Fly   332 PTNGQRGQQQLPLRMSADFAQAEQKLW----SLQAASS--STINE---NNNITKYNPGAANSLQG 387
            .|:..|...:..::.....|.:...|:    .|.:|..  :|||.   ...:..|...||.|...
pombe   265 TTHDMRMVLKKLIKRIEHVAHSHGLLYMSYKELMSAFERVATINPPAFKPFLDHYYAAAAQSFDS 329

  Fly   388 ---DCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKS-RRRSNLFIPSSSKKADKEKEPKSSELG 448
               |.::: ||:  .|..|..|...|.....:|.:|. ...|..:..|.|:...|.::..||:
pombe   330 FNIDRARL-LRN--FLIEPLRKIYDTDIKNVSTKKKDFEETSRDYYTSLSRYLSKSEKETSSD-- 389

  Fly   449 SGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVP 513
                           .:|......||:...|   .|..|    :.||.|::|
pombe   390 ---------------KTKESKFAAKKRDFEL---SRFDY----YSYMQDING------------- 419

  Fly   514 GQKPRGSKSIIT----------NSALT--SSLMANGQRAQNTLSDGIGCLTLAK----------- 555
            |:|.:...|::|          :|:||  .:|..:..:.|:.:::......|.:
pombe   420 GRKGQEVLSVLTSFAANDYNLIHSSLTDIDALRPSIIQLQDIVTEANKEFQLLRAEREERRRYIE 484

  Fly   556 DNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEG--IAMSNSNSQTFIAG--------- 609
            .:.|:|.:|     ...|||.|    .|:...|.||..:|  :|.|.|.|...:.|
pombe   485 TSSRELEDK-----DAEIAAQA----YKAKVDQDTSAKQGLLLAFSKSTSDLQVVGKSGWHKYWV 540

  Fly   610 --------EVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAAN 666
                    |.||....||..|..:.     :..::|:..::.... :.|.:::..:|: .::|.:
pombe   541 VLDHGKICEYANWKQSLELHTEPID-----LLMATVRPAQSVSRK-FCFEVITPQTKR-TYQATS 598

  Fly   667 SEERDEWVAAVEQEIF----------------------------KSLQSI-----------ESSK 692
            ..|...|:.|::..|.                            |:||.:           :|.:
pombe   599 KAEMHSWIEAIQYSISESIVQKGKGTSMNSEETSVKHGPTSTIGKALQRVASVTSPSRHNSDSKE 663

  Fly   693 TKQATSTDLAAMLAIRQRVPGNGFCVDCG-APNPEWASLNLGVLMCIECSGVHRNLGSHISKVRS 756
            .||..|..|...|  ::....:..|.||. ....||.::|..|::||:|||:||:||:||:|:||
pombe   664 KKQTKSPSLVKTL--KEMHSSDQSCADCNTTARVEWCAINFPVVLCIDCSGIHRSLGTHITKIRS 726

  Fly   757 LGLDDWPSPHLSVMLAIGNSLANSVWESN-TRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGN 820
            |.||.:....:.::.|.|||..|.::|.. |..::|  :..::|.:.::|:.||..|.|:    .
pombe   727 LTLDKFNPETVDLLYATGNSFVNEIYEGGITDWKIK--NFENQERRVQFVKDKYLYKRFI----K 785

  Fly   821 GSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQL 885
            .|.:|   .|...|:|::..:::|..|..||      ..|:|:.:......||.   .|..||:|
pombe   786 SSFSH---DPNTGLLESIEHSNLKEAVLCLA------LGADVNYQRAVVKALLK---NNYLIAEL 838

  Fly   886 LIWNGANIKHTDHEGRTCLAYARA 909
            |..|||::...:....|..|.|:|
pombe   839 LTLNGASLNVDEVTMETLSARAQA 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	38/209 (18%)
		RAS	144..295	CDD:214541	37/204 (18%)
		PH_AGAP	451..686	CDD:241281	52/304 (17%)
		PH	454..>521	CDD:278594	12/66 (18%)
		ArfGap	702..818	CDD:279720	39/117 (33%)
		ANK	<834..907	CDD:238125	20/72 (28%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	14/47 (30%)
		ANK repeat	868..897	CDD:293786	10/28 (36%)
cnt5	NP_595897.1	BAR_ArfGAP_fungi	257..455	CDD:153292	47/237 (20%)
		PH-like	513..614	CDD:302622	19/107 (18%)
		PH	532..614	CDD:278594	13/88 (15%)
		COG5347	671..>870	CDD:227651	65/212 (31%)
		ArfGap	674..787	CDD:279720	39/120 (33%)
		ANK repeat	791..821	CDD:293786	9/35 (26%)
		ANK repeat	822..847	CDD:293786	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9294
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840