DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and ACAP2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_016861535.1	Gene:	ACAP2 / 23527	HGNCID:	16469	Length:	848	Species:	Homo sapiens

Alignment Length:	706	Identity:	155/706 - (21%)
Similarity:	243/706 - (34%)	Gaps:	239/706 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 TSRKSRRRSNLFIPSSSKK---ADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVT 478
            |.|..:.:...|:....:|   |.|:.|..|.|         |:..|.|.:....||:.:.:..|
Human   129 TQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEE---------KENALVKNAQVQRNKQHEVEEAT 184

  Fly   479 -LCDDGRLTYHPSLHDYMDDVHGKEIPLQYV-TVKVPGQKPRGS--KSIIT-------------- 525
             :....|..:             :.|.|.|| .:.|...|.|..  ||:::
Human   185 NILTATRKCF-------------RHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYD 236

  Fly   526 -NSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQ 589
             .|.|...:...|.:....:.|       |...:|::.:|.|.:.....::.      .|.....
Human   237 LFSELGPYMKDLGAQLDRLVVD-------AAKEKREMEQKHSTIQQKDFSSD------DSKLEYN 288

  Fly   590 TSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKR-----------HRRMKSS-------- 635
            .....||.|     :.::....:||......:.|:..:|           .::.|.:
Human   289 VDAANGIVM-----EGYLFKRASNAFKTWNRKKPDHIRRWFSIQNNQLVYQKKFKDNPTVVVEDL 348

  Fly   636 ---SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSL--QSIESSKTKQ 695
               :||..| |....:.|.:|| .:|....:|.:.:.|..|:.||:..|..:.  :..||.|..:
Human   349 RLCTVKHCE-DIERRFCFEVVS-PTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDK 411

  Fly   696 ATSTDLAAM----------------LAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVH 744
            .:|....::                |...|.:|||..|.|||..:|.|||:|||:.:||||||:|
Human   412 KSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIH 476

  Fly   745 RNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNT-RQRVKPTSQASREDKERWVRSK 808
            |:||.|.||||||.||.|....|.:|..:||.:.|.|:|:|. :..:|......|::||.::|:|
Human   477 RSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAK 541

  Fly   809 YEAKEF-------LTP---------------------LGNGSSAHPS------------------ 827
            |..::|       |:|                     .|.|.....|
Human   542 YVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQVRASAQSSVIAVNSDEARRESL 606

  Fly   828 ----------------------------------------PS----------------------- 829
                                                    ||
Human   607 FCPDELDSLFSYFDTSSKLRSIRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDS 671

  Fly   830 ----PGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNG 890
                ||.||..|....::..:...||: .::|..|| |..:..|||:.|...|:|...:.|:.||
Human   672 KHLNPGLQLYRASYEKNLPKMAEALAH-GADVNWAN-SEENKATPLIQAVLGGSLVTCEFLLQNG 734

  Fly   891 ANIKHTD--------------HEGRTCLAYARAAQSLATAKSIK-----AAAAAQA 927
            ||:...|              |.|:.||...|.|...||.:..|     |..||.|
Human   735 ANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	47/277 (17%)
		PH	454..>521	CDD:278594	14/70 (20%)
		ArfGap	702..818	CDD:279720	54/160 (34%)
		ANK	<834..907	CDD:238125	24/86 (28%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	19/61 (31%)
		ANK repeat	868..897	CDD:293786	11/28 (39%)
ACAP2	XP_016861535.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850