DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenG1A and Git1

DIOPT Version :9

Sequence 1:NP_723849.1 Gene:CenG1A / 34803 FlyBaseID:FBgn0028509 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_001004144.1 Gene:Git1 / 216963 MGIID:1927140 Length:770 Species:Mus musculus


Alignment Length:220 Identity:70/220 - (31%)
Similarity:106/220 - (48%) Gaps:46/220 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   717 CVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSV 781
            |.||.||:|.|||::.|||:|.||..|||:||.|||.|:.|....||...|.::..:.::.|||:
Mouse    11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSI 75

  Fly   782 WE---------------SNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPL----GNGSSAHPS 827
            ||               :|.:.:|.|.       |..::|:||:...|:..|    .:|.:|   
Mouse    76 WEHSLLDPAQVQSGRRKANPQDKVHPI-------KSEFIRAKYQMLAFVHKLPCRDDDGVTA--- 130

  Fly   828 PSPGQQLIEAVIRADIKSIVSIL-----ANC--PSEVTNANVSARDVRTPLLLACAIGNLAIAQL 885
            ....:||..:|...::::.:.:|     ||.  |.:.|          |||.:|...|....|:|
Mouse   131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGT----------TPLHVAAKAGQTLQAEL 185

  Fly   886 LIWNGANIKHTDHEGRTCLAYARAA 910
            |:..||:....|..|||.:.|||.|
Mouse   186 LVVYGADPGSPDVNGRTPIDYARQA 210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenG1ANP_723849.1 SelP_N <5..41 CDD:282453
Centaurin_gamma 143..300 CDD:133303
RAS 144..295 CDD:214541
PH_AGAP 451..686 CDD:241281
PH 454..>521 CDD:278594
ArfGap 702..818 CDD:279720 41/115 (36%)
ANK <834..907 CDD:238125 21/79 (27%)
ANK repeat 834..866 CDD:293786 7/38 (18%)
Ank_5 859..907 CDD:290568 14/47 (30%)
ANK repeat 868..897 CDD:293786 10/28 (36%)
Git1NP_001004144.1 Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 1..124 42/119 (35%)
ArfGap_GIT1 1..111 CDD:350071 38/106 (36%)
ANK 1 132..161 5/28 (18%)
Ank_2 137..229 CDD:372319 25/84 (30%)
ANK repeat 137..165 CDD:293786 5/27 (19%)
ANK 2 166..195 11/38 (29%)
ANK repeat 167..197 CDD:293786 11/39 (28%)
ANK 3 199..228 7/12 (58%)
Interaction with PCLO. /evidence=ECO:0000250|UniProtKB:Q9Z272 245..374
Interaction with PTK2/FAK1. /evidence=ECO:0000250|UniProtKB:Q9Z272 253..424
Interaction with ARHGEF7. /evidence=ECO:0000250|UniProtKB:Q9Z272 254..376
GIT_SHD <281..301 CDD:369921
GIT_SHD 337..365 CDD:369921
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..425
Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250|UniProtKB:Q9Z272 375..596
Required for localization at synapses. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 375..596
GIT_CC 418..482 CDD:374629
Interaction with MAPK1. /evidence=ECO:0000269|PubMed:15923189 420..475
Interaction with IKBKG. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 429..629
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..615
Interaction with PXN and TGFB1I1. /evidence=ECO:0000250|UniProtKB:Q9Z272 646..770
GIT1_C 649..763 CDD:371961
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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