DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and Acap1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_722483.2	Gene:	Acap1 / 216859	MGIID:	2388270	Length:	740	Species:	Mus musculus

Alignment Length:	564	Identity:	140/564 - (24%)
Similarity:	205/564 - (36%)	Gaps:	204/564 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 NLFIPSSSKKADKEKEP---KSSELG---------SGRSIPIKQGYLYKRSSKSLNKEWKKKYVT 478
            ||.:.|:.:|.|.|:..   |..|||         .|.|..:.:|:|:||:|.:. |.|.:::.|
Mouse   226 NLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRASNAF-KTWSRRWFT 289

  Fly   479 LCDDGRLTYHPSLHD----YMDDVHGKEIPLQYVTVKV-PGQKPRGSKSIITNSALTSSLMANGQ 538
            : .:.:|.|.....|    .:||       |:..|||: |..:.|....:::.|.
Mouse   290 I-QNNQLVYQKKYKDPVTVVVDD-------LRLCTVKLCPDSERRFCFEVVSTSK---------- 336

  Fly   539 RAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQ---QTSGDEGIAMSN 600
                      .|. |..|::|.|  :|.:....|..|.|..:....||.:   |.||..    :.
Mouse   337 ----------SCF-LQADSERLL--QLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYH----AP 384

  Fly   601 SNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWHFEAA 665
            .::.|...|..|                 |..:|..|
Mouse   385 GSAATLACGGAA-----------------RGRESGGV---------------------------- 404

  Fly   666 NSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASL 730
                                             ..:||.:   |.|.||..|.||..|.|||||:
Mouse   405 ---------------------------------GQVAAQV---QSVDGNAQCCDCREPAPEWASI 433

  Fly   731 NLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRV--KPT 793
            ||||.:||:|||:||:||.|.||||||.||.|....:.:|..:||.:.|.::|:......  ||.
Mouse   434 NLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPG 498

  Fly   794 SQASREDKERWVRSKYEAKEFLTPL--------GNG-SSAHP--SPSPGQQLIEAVIRADIKSIV 847
            ...||::||.|:.:||..|:|||.|        |.| ...||  .|.|..:....::|:.
Mouse   499 PSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSK----- 558

  Fly   848 SILANCPSE-----------------------VTNANVSARDVR---------TPLLLACAIGNL 880
               :.|||:                       :.:|.....||.         |||:.|.|..:|
Mouse   559 ---SECPSDDMGSLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSL 620

  Fly   881 AIAQLLIWNGANIKHTD--------------HEGRTCLAYARAA 910
            ...:.|:.||||:...|              |.|..||...|.|
Mouse   621 LACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGA 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	41/242 (17%)
		PH	454..>521	CDD:278594	19/71 (27%)
		ArfGap	702..818	CDD:279720	56/117 (48%)
		ANK	<834..907	CDD:238125	23/118 (19%)
		ANK repeat	834..866	CDD:293786	5/54 (9%)
		Ank_5	859..907	CDD:290568	19/70 (27%)
		ANK repeat	868..897	CDD:293786	11/37 (30%)
Acap1	NP_722483.2	Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250\|UniProtKB:Q15027	1..382		46/187 (25%)
		BAR_ACAP1	18..217	CDD:153323
		PH	266..360	CDD:278594	27/125 (22%)
		PH_ACAP	268..364	CDD:270070	29/127 (23%)
		Required for interaction with GULP1. /evidence=ECO:0000250\|UniProtKB:Q15027	405..740		88/271 (32%)
		ArfGap	406..519	CDD:279720	53/115 (46%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250	525..566		10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..562		7/44 (16%)
		Ank_2	575..670	CDD:289560	21/90 (23%)
		ANK repeat	575..602	CDD:293786	3/26 (12%)
		ANK	<592..692	CDD:238125	20/73 (27%)
		ANK repeat	606..637	CDD:293786	11/30 (37%)
		ANK repeat	639..670	CDD:293786	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850