DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and Agap3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_006535736.1	Gene:	Agap3 / 213990	MGIID:	2183446	Length:	1093	Species:	Mus musculus

Alignment Length:	948	Identity:	424/948 - (44%)
Similarity:	553/948 - (58%)	Gaps:	121/948 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PTAAASASGAPSSSASASASASILVAH----PPQPLISNSLAIRQEI--QRFESVHPSIYAIYEL 102
            |.|...:.|..||..:..:...:|.|.    ||:|....:.|...::  .||....|:
Mouse   214 PRARTRSDGDASSLGTFPSRRDLLGADTPCAPPEPGRPRAAASLWKLLTSRFRRREPA------- 271

  Fly   103 IDLLPMAD--AQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTG 165
                |.|.  ::.|.:....:....||||||||||:|||||:|::||||:|:|||||||||||||
Mouse   272 ----PSAPLWSRRAAAAPGLLGAPSDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTG 332

  Fly   166 SYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYY 230
            :|:|||||||||||||:.:||||||||||||||.||:|||.|||||:||||||:|.||.|||||:
Mouse   333 TYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYF 397

  Fly   231 TKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQD 295
            .::..|||..|:||:|||||||||..|||||||:|||||::|||||:||||||||||||||||||
Mouse   398 LRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQD 462

  Fly   296 ACQKILSQRLPLPPQVQPAR--PTTPQGNRLGLAPYQA-----PTNGQRGQQQLPLRMSADFAQA 353
            ..||:::.|......:.|.:  |.:|..:.:..|...|     .|||
Mouse   463 VAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNG------------------ 509

  Fly   354 EQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTS 418
                      .||..::.::.....|        ..||.:||          .|....:||||..
Mouse   510 ----------GSSAFSDYSSSVPSTP--------SISQRELR----------IETIAASSTPTPI 546

  Fly   419 RK-SRRRSNLFIPSSSKKADKEKEPKSSE-----LGSGRSIPIKQGYLYKRSSKSLNKEWKKKYV 477
            || |:||||:|  :|.|.||.::|.|::|     :||||:||||||.|.|||.||||||||||||
Mouse   547 RKQSKRRSNIF--TSRKGADLDREKKAAECRVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYV 609

  Fly   478 TLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQK-PRGSKSIITNSALTSSLMANG---Q 538
            ||||:|.|||||||||||.::|||||.|...||||||:: ||.:.:    :|..:|..|||   :
Mouse   610 TLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPT----TAPGTSPRANGLAME 670

  Fly   539 RAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGD---EGIAMSN 600
            |:...|....|....|...........|...|||   ..|.|.|...|...:|.|   |..|:.
Mouse   671 RSNTQLGGATGAPHSASSTSLHSERPHSSAWAGS---RPGPEGLHQRSCSVSSTDQWSEAAALP- 731

  Fly   601 SNSQTFIAGEVANAGNKLEAQTP----NVKKRHRRMKSS--------SVKANEADDNDGYEFYIV 653
            ::.|...:|...:..:..:.:.|    :.:|:||..||:        |..|.||:::  :||.:|
Mouse   732 ASMQHPASGPAESLSSSPKLEPPPSPHSNRKKHRGKKSTGTPRPDGPSSAAEEAEES--FEFVVV 794

  Fly   654 SLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESS--KTKQATSTDLAAMLAIRQRVPGNGF 716
            ||..:.|||||:.:|||:.||.:|:.:|..|||...|:  ||:........|:.|:| .|.||..
Mouse   795 SLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNTALAVQAVR-TVRGNSL 858

  Fly   717 CVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSV 781
            |:||.||||:|||||||.||||||||:||:||:|:|:||||.|||||...|:||.|:||:|||||
Mouse   859 CIDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSV 923

  Fly   782 WESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSI 846
            ||.......||..:|.||:||||:|:|||.|.||.||  .||..|.   ||||:.||:..|::.:
Mouse   924 WEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPL--PSSDVPL---GQQLLRAVVEDDLRLL 983

  Fly   847 VSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQ 911
            |.:||:...|..|......|.||.|.|:.|:.|:...|||||.|.:::..|..|.|.|||||.|.
Mouse   984 VMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAG 1048

  Fly   912 SLATAKSIKAAAAAQAGTTIPAPAP---PTNGGIPAPQ 946
            |...|..:........|..: ||.|   |.||..|:.:
Mouse  1049 SQECADILIQHGCPGEGCGL-APTPNREPANGTNPSAE 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	122/156 (78%)
		RAS	144..295	CDD:214541	118/150 (79%)
		PH_AGAP	451..686	CDD:241281	104/253 (41%)
		PH	454..>521	CDD:278594	51/67 (76%)
		ArfGap	702..818	CDD:279720	72/115 (63%)
		ANK	<834..907	CDD:238125	27/72 (38%)
		ANK repeat	834..866	CDD:293786	9/31 (29%)
		Ank_5	859..907	CDD:290568	19/47 (40%)
		ANK repeat	868..897	CDD:293786	12/28 (43%)
Agap3	XP_006535736.1	Centaurin_gamma	310..467	CDD:133303	122/156 (78%)
		PH_AGAP	583..827	CDD:241281	104/253 (41%)
		PRK07003	<645..>756	CDD:235906	28/118 (24%)
		ArfGap_AGAP3	843..952	CDD:350080	67/109 (61%)
		Ank_2	971..1061	CDD:372319	33/89 (37%)
		ANK repeat	971..1001	CDD:293786	9/29 (31%)
		ANK repeat	1003..1034	CDD:293786	13/30 (43%)
		ANK repeat	1036..1061	CDD:293786	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1961
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	750	1.000	Inparanoid score	I572
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	1	1.000	-	-		otm43977
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870