DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AgaP_AGAP003133

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_312819.5	Gene:	AgaP_AGAP003133 / 1273805	VectorBaseID:	AGAP003133	Length:	1055	Species:	Anopheles gambiae

Alignment Length:	852	Identity:	155/852 - (18%)
Similarity:	242/852 - (28%)	Gaps:	376/852 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RHNHAAPTAAASASGAPSSSASASASAS----ILVAHPPQP-------LISNSLAIRQEIQRFES 91
            |.:.|.||...|.|.:.:|.||:.|..:    |..|.||.|       ..|::.|
Mosquito   381 RGDDAEPTVGLSPSPSVASIASSGAGGTSIRPIRPAPPPPPGGGGGGSSASSARA---------- 435

  Fly    92 VHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSLNSGKS 156
                          .|:.....:|..|..    ..|..::|...|..|     .|..|....|.|
Mosquito   436 --------------SPVGTPVPSQRRRSS----PGSSESAQATAIEAS-----SGEAGDTTPGPS 477

  Fly   157 ALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEG 221
            |.:      :...:|.|..     ...::|.:       |||||
Mosquito   478 API------ATADDEQPNA-----SAPVNGSA-------EGGAP--------------------- 503

  Fly   222 SFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYG 286
              :||                               ||.:.:|....:.|:       :|.||
Mosquito   504 --STV-------------------------------PREVSETATSSIGSE-------QTAAT-- 526

  Fly   287 LNVERVFQDACQKILSQRLPLPPQ-------VQPARPTTP----QGNRLGLAPYQAPTNGQRGQQ 340
                              .|..|.       ..|:.||||    |.|..||.|.
Mosquito   527 ------------------TPNRPDTAVAVQPTSPSHPTTPAPAAQPNATGLPPG----------- 562

  Fly   341 QLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPR-DLAPPP 404
                             |::|.||:..:...::|.|.....              ||| .||.|
Mosquito   563 -----------------WAVQVASNGRLFFIDHINKTTSWV--------------DPRTGLASP- 595

  Fly   405 GKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKS-- 467
                                    |||::...........|..|||..   .:|  ..|||..
Mosquito   596 ------------------------IPSAAGSDGVAAGGAGSTAGSGHG---SRG--DSRSSDDNL 631

  Fly   468 --LNKEWKKKYVTLCDDGRLTY--HPSLHDYMDD-------VHGKEIPL------QYVTVKVPGQ 515
              |.:.|:::   :..|||..:  |.:.....||       :.|:.:|.      :|...|...|
Mosquito   632 GPLPEGWEER---VHSDGRTFFIDHNTRTTQWDDPRLSNPKIAGQAVPYSRDYKQKYEYFKSQLQ 693

  Fly   516 KPRGSKSIITNSALTSSLMANGQRAQNTLS----------------DGIGCLTLAKDNQRKLSEK 564
            ||....:.|......:|::.:..|..|:::                .|:....||::....||::
Mosquito   694 KPSNVPNKIDIKVRRASILEDSYRVINSVTRLDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKE 758

  Fly   565 LSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANA----GNKLEAQTPNV 625
            :.....|.....|     ..|.:.|.:.:.|:.    |.:....|.:|..    |..|:|..  :
Mosquito   759 MFNPYYGLFEYSA-----MDNYTLQINPNSGLC----NEEHLFIGRIAGMAIYHGKLLDAFF--I 812

  Fly   626 KKRHRRM--KSSSVKANEADDNDGYE--FYI---------------------------------- 652
            :..::.|  ||..:|..||.|.:.|.  .||
Mosquito   813 RPFYKMMLQKSIDLKDMEAVDTEYYNSLLYIKENDPSTLMLTFSVDEESFGTTNQRELKPNGADL 877

  Fly   653 -VSLDSK--------QWHFEAANSEERDEWVAAVEQ-------EIFK---------SLQSIESSK 692
             ||.::|        .|.|||...::...::..|..       :||.         .:|||:.:.
Mosquito   878 EVSNENKDEYIRLVIDWRFEARVKDQMQAFLEGVSSLVPLHLLKIFDENELELLMCGIQSIDVND 942

  Fly   693 TKQAT--STDLAAMLAIRQ-------------------------RVPGNGFCVDCGAPNPE---- 726
            .|:.|  ..|..|..|:.|                         |||.|||....|:..|:
Mosquito   943 WKKNTMYKGDYYANHAVVQWFWRAVLSFNNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQLFTI 1007

  Fly   727 --WASLN 731
              |.::|
Mosquito  1008 EKWGTVN 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453	1/2 (50%)
		Centaurin_gamma	143..300	CDD:133303	22/156 (14%)
		RAS	144..295	CDD:214541	22/150 (15%)
		PH_AGAP	451..686	CDD:241281	59/336 (18%)
		PH	454..>521	CDD:278594	19/85 (22%)
		ArfGap	702..818	CDD:279720	13/61 (21%)
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
AgaP_AGAP003133	XP_312819.5	C2	45..179	CDD:301316
		WW	246..275	CDD:278809
		WW	559..588	CDD:278809	8/70 (11%)
		WW	633..665	CDD:197736	8/34 (24%)
		HECTc	702..1051	CDD:238033	59/324 (18%)
		HECTc	726..1051	CDD:214523	55/300 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910