DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and AgaP_AGAP000563

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_310516.5	Gene:	AgaP_AGAP000563 / 1271660	VectorBaseID:	AGAP000563	Length:	983	Species:	Anopheles gambiae

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	149/391 - (38%)	Gaps:	106/391 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 GSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIP------LQ 506
            |..|:....:|||:||:|.:. |.|.:::..: .|.:|.|....        |:|:|      |:
Mosquito   297 GGARTPSYMEGYLFKRTSNAF-KTWNRRWFCM-RDNQLFYRKRT--------GEELPTVMEEDLR 351

  Fly   507 YVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQN----TLSDGIGCLTLAKDNQRKLSEKLSL 567
            ..||:......|.....:.:...:..|.|:.:...:    .|..||.  :..:.|....|:...|
Mosquito   352 LCTVRQLADSDRRYCFEVISPTKSHILQADSEAMMSAWIKALQKGID--SAIQHNSGYSSDMRGL 414

  Fly   568 LGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRM 632
            ...|....|.||......::...||..|...::::.:     |.|..|...:......||.:
Mosquito   415 AAGGGPGGGVGGPGGSGAAAASDSGRPGDGRTDASGR-----ERAGTGRASDGSRKGFKKIN--- 471

  Fly   633 KSSSVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQAT 697
                                                    |...:
Mosquito   472 ----------------------------------------WTQML-------------------- 476

  Fly   698 STDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDW 762
                        ::|||..|.|||..:|.|||:|||:.:||.||||||:||.|.||||||.||.|
Mosquito   477 ------------KIPGNSRCADCGNADPRWASINLGITLCIACSGVHRSLGVHYSKVRSLTLDVW 529

  Fly   763 PSPHLSVMLAIGNSLANSVWESNTRQRV---KPTSQASREDKERWVRSKYEAKEFLTPLGN-GSS 823
            ....|.||:.:||.:.|.|:|.|..:..   :.|.......:|.|:|:||..::|:.|||. ||.
Mosquito   530 EPEILRVMIELGNDVINRVYEGNAARLARFDRATDNCEIAVREAWIRAKYIDRQFVVPLGGLGSG 594

  Fly   824 A 824
            |
Mosquito   595 A 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	40/244 (16%)
		PH	454..>521	CDD:278594	18/72 (25%)
		ArfGap	702..818	CDD:279720	50/118 (42%)
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
AgaP_AGAP000563	XP_310516.5	BAR_3	6..239	CDD:293351
		PH	304..397	CDD:278594	21/102 (21%)
		PH_ACAP	305..400	CDD:270070	23/106 (22%)
		ArfGap	469..585	CDD:279720	51/190 (27%)
		ANK	777..896	CDD:238125
		Ank_2	780..874	CDD:289560
		ANK repeat	780..806	CDD:293786
		ANK repeat	812..841	CDD:293786
		ANK repeat	843..874	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820