DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP4

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001263272.2	Gene:	AGAP4 / 119016	HGNCID:	23459	Length:	686	Species:	Homo sapiens

Alignment Length:	839	Identity:	280/839 - (33%)
Similarity:	375/839 - (44%)	Gaps:	201/839 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSL 151
            |:..||.||...|||......||.|.:|.:::...|.:|
Human    19 QQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVE-------------------------- 57

  Fly   152 NSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFS 216
             .|:...:|.     ....|.||...|.            |..:...:...|.....||:.|..|
Human    58 -VGEDLHMHH-----VRDREMPEALEFN------------LSANPEASTIFQRNSQTDALEFNPS 104

  Fly   217 LENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYET 281
            ...|.|  |::.        ||.|         .|.:..|.      :......|.::....|..
Human   105 ANPEAS--TIFQ--------RNSQ---------TDVVEIRR------SNCTNHVSTVRFSQQYSL 144

  Fly   282 CATYGLNVERVFQD-ACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLR 345
            |:|..|:.....|. ....|:|..|.:|..:     |....:|               ...:|..
Human   145 CSTIFLDDSTAIQHYLTMTIISVTLEIPHHI-----TQRDADR---------------SLSIPDE 189

  Fly   346 MSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPT 410
            ....||.:...:...:....|..|.:::|    |...::.|        .||: .:.||....||
Human   190 QLHSFAVSTVHIMKKRNGGGSLNNYSSSI----PSTPSTSQ--------EDPQ-FSVPPTANTPT 241

  Fly   411 PTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSE-----LGSGRSIPIKQGYLYKRSSKSLNK 470
            |     ..::|.|.||||  :|.|.:|.:||.|:.|     :||||:||||||.|.|||.|.| |
Human   242 P-----VCKRSMRWSNLF--TSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298

  Fly   471 EWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALT--SSL 533
            .|||||||||.:|.|||:.||.|||.::|.|||.||..|:||||:.|.     :..||.|  |:.
Human   299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPS-----LATSACTPISTS 358

  Fly   534 MANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAM 598
            .:||               |:||                :..|.|               :.|..
Human   359 KSNG---------------LSKD----------------MDTGLG---------------DSICF 377

  Fly   599 SNSNSQTFIAGEVANAGNKLE-AQTPNV-KKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQWH 661
            |.|.|.|        ...||. ..:|:. ||:|.:.||::            .|.|||...:.||
Human   378 SPSISST--------TSPKLNPPPSPHANKKKHLKKKSTN------------NFMIVSATGQTWH 422

  Fly   662 FEAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QATSTDLAAMLAIRQRVPGNGFCVDCGAPNP 725
            |||...||||.||.|::.:|..||||.||||:| |.||...|..|...|.:.||..||||...||
Human   423 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNP 487

  Fly   726 EWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRV 790
            :||||||||||||||||:||:||:.:|:||||.|||||.....||.:|||.||||:||.:::.:.
Human   488 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT 552

  Fly   791 KPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSP--SPGQQLIEAVIRADIKSIVSILANC 853
            ||:.:::||:||||:|||||.|.||.||       |..  |.||||:.|....|:::.:.:||:.
Human   553 KPSEKSTREEKERWIRSKYEEKLFLAPL-------PCTELSLGQQLLRATADEDLQTAILLLAHG 610

  Fly   854 PSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQS 912
            ..|..|......|..|.|.|||..||:.:||||||.|.::...|..|.|.|.|||.|.|
Human   611 SREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASS 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	26/157 (17%)
		RAS	144..295	CDD:214541	25/150 (17%)
		PH_AGAP	451..686	CDD:241281	86/238 (36%)
		PH	454..>521	CDD:278594	42/66 (64%)
		ArfGap	702..818	CDD:279720	68/115 (59%)
		ANK	<834..907	CDD:238125	26/72 (36%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	20/47 (43%)
		ANK repeat	868..897	CDD:293786	14/28 (50%)
AGAP4	NP_001263272.2	PH_AGAP	280..447	CDD:241281	86/238 (36%)
		PH	283..442	CDD:278594	82/230 (36%)
		ArfGap	466..580	CDD:279720	67/113 (59%)
		Ank_2	591..681	CDD:289560	31/79 (39%)
		ANK repeat	591..621	CDD:293786	7/29 (24%)
		ANK	<594..677	CDD:238125	30/76 (39%)
		ANK repeat	623..654	CDD:293786	15/30 (50%)
		ANK repeat	656..681	CDD:293786	8/14 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4206
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2762
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730