DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_114152.3	Gene:	AGAP3 / 116988	HGNCID:	16923	Length:	911	Species:	Homo sapiens

Alignment Length:	965	Identity:	454/965 - (47%)
Similarity:	585/965 - (60%)	Gaps:	125/965 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PPQRHNHAAPTAAASAS----------GAPSSSASASASASILVAHPPQPL-ISNSLAIRQEIQR 88
            |.|:.:.|||....:|:          ||...:......:..|...|||.. :|||.|||.||||
Human    11 PQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQR 75

  Fly    89 FESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSLNS 153
            ||||||:|||||:||:.:  .|..:...||:||:.||||||||||||:|||||:|::||||:|:|
Human    76 FESVHPNIYAIYDLIERI--EDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSS 138

  Fly   154 GKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLE 218
            ||||||||||||:|:|||||||||||||:.:||||||||||||||.||:|||.|||||:||||||
Human   139 GKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLE 203

  Fly   219 NEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCA 283
            :|.||.|||||:.::..|||..|:||:|||||||||..|||||||:|||||::|||||:||||||
Human   204 DEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCA 268

  Fly   284 TYGLNVERVFQDACQKILSQRLPLPPQVQPAR--PTTPQGNRLGLAPYQA-----PTNGQRGQQQ 341
            ||||||||||||..||:::.|......:.|.:  |.:|..:.:..|...|     .|||
Human   269 TYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNG------ 327

  Fly   342 LPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGK 406
                                  ..|..::.::.....|        ..||.:||          .
Human   328 ----------------------GGSAFSDYSSSVPSTP--------SISQRELR----------I 352

  Fly   407 ELPTPTSTPTTSRK-SRRRSNLFIPSSSKKADKEKEPKSSE-----LGSGRSIPIKQGYLYKRSS 465
            |....:||||..|| |:||||:|  :|.|.||.::|.|::|     :||||:||||||.|.|||.
Human   353 ETIAASSTPTPIRKQSKRRSNIF--TSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSG 415

  Fly   466 KSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQK-PRGSKSIITNSAL 529
            ||||||||||||||||:|.|||||||||||.::|||||.|...||||||:: ||.:.:    :|.
Human   416 KSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPA----TAP 476

  Fly   530 TSSLMANG---QRAQNTLSDGIGCLTLAKD----NQRKLSEKLSLLGAGSIAAGAGGEPLKSNSS 587
            .:|..|||   :|:...|..|.|....|..    ::|.||        .|..||...|.|...|.
Human   477 GTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLS--------SSAWAGPRPEGLHQRSC 533

  Fly   588 QQTSGDEGIAMSNS---NSQTFIAG--EVANAGNKLE-AQTPNV-KKRHRRMKSS--------SV 637
            ..:|.|:....:.|   ..|...:|  ||.::..||: ..:|:. :|:|||.||:        |.
Human   534 SVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSS 598

  Fly   638 KANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLA 702
            ...||:::  :||.:|||..:.|||||:.:|||:.||.:|:.:|..|||...|:|.|.......|
Human   599 ATEEAEES--FEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNA 661

  Fly   703 AMLAIR--QRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSP 765
            | ||::  :.|.||.||:||.||||:|||||||.||||||||:||:||:|:|:||||.|||||..
Human   662 A-LAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPE 725

  Fly   766 HLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSP 830
            .|:||.|:||:|||||||.......||...|.||:||||:|:|||.|.||.||.:      |..|
Human   726 LLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS------SDVP 784

  Fly   831 -GQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIK 894
             ||||:.||:..|::.:|.:||:...|..|......|.||.|.|:.|:.|:...|||||.|.:::
Human   785 LGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVR 849

  Fly   895 HTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAP---PTNGGIPAPQ 946
            ..|..|.|.|||||.|.|...|..:........|..: ||.|   |.||..|:.:
Human   850 SRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGL-APTPNREPANGTNPSAE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453	2/5 (40%)
		Centaurin_gamma	143..300	CDD:133303	122/156 (78%)
		RAS	144..295	CDD:214541	118/150 (79%)
		PH_AGAP	451..686	CDD:241281	109/257 (42%)
		PH	454..>521	CDD:278594	51/67 (76%)
		ArfGap	702..818	CDD:279720	74/117 (63%)
		ANK	<834..907	CDD:238125	27/72 (38%)
		ANK repeat	834..866	CDD:293786	9/31 (29%)
		Ank_5	859..907	CDD:290568	19/47 (40%)
		ANK repeat	868..897	CDD:293786	12/28 (43%)
AGAP3	NP_114152.3	small_GTPase	126..291	CDD:197466	125/164 (76%)
		Centaurin_gamma	128..285	CDD:133303	122/156 (78%)
		PH_AGAP	401..645	CDD:241281	109/257 (42%)
		PH	404..>465	CDD:278594	48/60 (80%)
		ArfGap	664..778	CDD:279720	71/113 (63%)
		Ank_2	789..879	CDD:289560	33/89 (37%)
		ANK	789..>878	CDD:238125	33/88 (38%)
		ANK repeat	789..819	CDD:293786	9/29 (31%)
		ANK repeat	821..852	CDD:293786	13/30 (43%)
		ANK repeat	854..879	CDD:293786	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1983
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	747	1.000	Inparanoid score	I586
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	1	1.000	-	-		otm41929
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	O	PTHR45819
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870