DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and AGAP1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_006712302.2	Gene:	AGAP1 / 116987	HGNCID:	16922	Length:	1151	Species:	Homo sapiens

Alignment Length:	1001	Identity:	426/1001 - (42%)
Similarity:	538/1001 - (53%)	Gaps:	199/1001 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PPQRHNHAAPTAAASASGAPSSSASASASASILVAHPPQPLISNSLAIRQEIQRFESVHPSIYAI 99
            |..|...:.|....|...||:.:.|:||
Human   283 PSPRSGASRPRGYFSLRRAPAEAHSSSA------------------------------------- 310

  Fly   100 YELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLT 164
             |.||..|..||                ||||||||:|||||:|::||||:|.||||||||||||
Human   311 -ESIDGSPRRDA----------------FVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLT 358

  Fly   165 GSYMQEESPE----GGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNT 225
            |:|:||||||    |||||||:.:||||||||||||||.||.|||.||||||||||||:|.||.|
Human   359 GTYVQEESPEDMDAGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQT 423

  Fly   226 VYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVE 290
            ||:||::||::||..|||::|||||||||..|||||||.|||||::|||||:|||||||||||||
Human   424 VYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVE 488

  Fly   291 RVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQ 355
            |||||..|||::.|               :..:|.:.|.::..|.       |...|...||..
Human   489 RVFQDVAQKIVATR---------------KKQQLSIGPCKSLPNS-------PSHSSVCSAQVS- 530

  Fly   356 KLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRK 420
                 ....|.|.|...:::.|:....::  ...||.:||    :..||....|||     ..::
Human   531 -----AVHISQTSNGGGSLSDYSSSVPST--PSTSQKELR----IDVPPTANTPTP-----VRKQ 579

  Fly   421 SRRRSNLFIPSSSKKADKEK---EPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDD 482
            |:||||||........||||   |.::..:||||:||||||.|.|||.||||||||||||||||:
Human   580 SKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDN 644

  Fly   483 GRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANG---QRAQNTL 544
            |.|||||||||||.:||||||.|...||||||::|..:.|.   .|..||...||   ..:...:
Human   645 GVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSA---CAPISSPKTNGLSKDMSSLHI 706

  Fly   545 SDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAG 609
            |...|.:|.|..:|  ::..:||:...|...|........:|:.|.|....||.|..:|.|.:..
Human   707 SPNSGNVTSASGSQ--MASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGD 769

  Fly   610 EVANAGNKLEAQTPNV---------KKRHRRMKS-SSVKA------------------------- 639
            .|.::.:.....:|.:         :|:|||.|| |:.||
Human   770 SVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEAKRKAWKLNRVGSLRNI 834

  Fly   640 -----NEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTK-QATS 698
                 |..:..:.:||.||||..:.|||||...||||.||.|:|.:|..||||.||||.| :.||
Human   835 YSSSTNTEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTS 899

  Fly   699 TDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWP 763
            ...|..|...:.:.||..||||...||.|||||||.||||||||:|||||:|:|:||||.|||||
Human   900 QSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWP 964

  Fly   764 SPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSP 828
            ...:.||.:|||.|||||||.:::.|.||:..::||:||||:|:|||.|.||.||       |..
Human   965 VELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPL-------PCT 1022

  Fly   829 --SPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGA 891
              |.||.|:.|....|:::.:.:||:...:..|......|.||.|.|||..||:.:||||||.|.
Human  1023 ELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGV 1087

  Fly   892 NIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALV 956
            ::...|..|.|.|||||.|.|                                        ...:
Human  1088 DVTARDAHGNTALAYARQASS----------------------------------------QECI 1112

  Fly   957 ELLEGLGCP-EAAPLTASGTLPRRRD 981
            ::|...||| |...|.|:..|.||.:
Human  1113 DVLLQYGCPDERFVLMATPNLSRRNN 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453	2/5 (40%)
		Centaurin_gamma	143..300	CDD:133303	124/160 (78%)
		RAS	144..295	CDD:214541	120/154 (78%)
		PH_AGAP	451..686	CDD:241281	109/277 (39%)
		PH	454..>521	CDD:278594	51/66 (77%)
		ArfGap	702..818	CDD:279720	69/115 (60%)
		ANK	<834..907	CDD:238125	27/72 (38%)
		ANK repeat	834..866	CDD:293786	6/31 (19%)
		Ank_5	859..907	CDD:290568	22/47 (47%)
		ANK repeat	868..897	CDD:293786	15/28 (54%)
AGAP1	XP_006712302.2	Centaurin_gamma	337..498	CDD:133303	124/160 (78%)
		RAS	338..504	CDD:214541	126/180 (70%)
		PH_AGAP	613..886	CDD:241281	109/277 (39%)
		PH	616..>680	CDD:278594	50/63 (79%)
		PH	<830..881	CDD:278594	20/50 (40%)
		ArfGap	905..1019	CDD:279720	68/113 (60%)
		Ank_2	1030..1120	CDD:289560	33/129 (26%)
		ANK	1030..>1119	CDD:238125	33/128 (26%)
		ANK repeat	1062..1093	CDD:293786	16/30 (53%)
		ANK repeat	1095..1120	CDD:293786	10/64 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1983
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56689
Inparanoid	1	1.050	747	1.000	Inparanoid score	I586
Isobase	1	0.950	-	0	Normalized mean entropy	S2762
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	1	1.000	-	-		otm41929
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	LDO	PTHR45819
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820