DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenG1A and AGAP2

DIOPT Version :9

Sequence 1:NP_723849.1 Gene:CenG1A / 34803 FlyBaseID:FBgn0028509 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_001116244.1 Gene:AGAP2 / 116986 HGNCID:16921 Length:1192 Species:Homo sapiens


Alignment Length:994 Identity:363/994 - (36%)
Similarity:504/994 - (50%) Gaps:190/994 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 PPPQRHNHAAPTAAASASGAPSSSASASASASILVAHPPQPLISN-------SLAIRQEIQRFES 91
            |||.    ..|...:.|:...::||.....|..:...||.|.:..       |...|:.::....
Human   290 PPPL----TLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISG 350

  Fly    92 VH----------------PSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDSFVNSQEWTISRSV 140
            :.                ||:.:.....:||   .|::..|.:        :.:||||||:|||:
Human   351 IFTKSTGGPPGSGPLPGPPSLSSGSGSRELL---GAELRASPK--------AVINSQEWTLSRSI 404

  Fly   141 PDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFA 205
            |:||||::|...||||:|:||:|||||...|..|..::|||:.:|||::|:|||:|.|||:.:|:
Human   405 PELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFS 469

  Fly   206 GWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQE--IPMILVGTQDAISERNPRVIDDTRARK 268
            ||.||||||||||:|.||..|...:.:::..|....  :.:.||||||.||..:|||:.|.|||.
Human   470 GWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARA 534

  Fly   269 LASDLKRCSYYETCATYGLNVERVFQDACQKILSQR-----------LPLPPQVQPARPTTPQGN 322
            |.:|:||||||||||||||||:||||:..||:::.|           ||..|....|  :||...
Human   535 LCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAA--STPVAG 597

  Fly   323 RLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQG 387
                   ||...|........|..|.:....|.:..:...|..||           ||:.:    
Human   598 -------QASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLST-----------PGSLH---- 640

  Fly   388 DCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEK---EPKSSELGS 449
                                           |.::||::||  ::.:.:|.||   :.:....||
Human   641 -------------------------------RAAKRRTSLF--ANRRGSDSEKRSLDSRGETTGS 672

  Fly   450 GRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPG 514
            ||:|||||.:|.|||..|||||||||||||..:|.|.||||::||:...||||:.|...||||||
Human   673 GRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG 737

  Fly   515 QKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGG 579
            ::|..:.|....||..:.|:.:....|                          :|.|..|.....
Human   738 KRPPRAISAFGPSASINGLVKDMSTVQ--------------------------MGEGLEATTPMP 776

  Fly   580 EPLKSNSS-----QQTS-----GDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKS 634
            .|..|.||     .|||     .|..:|.:.|...| .:|:::....: ...:|.|||:.|:..:
Human   777 SPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCT-PSGDLSPLSRE-PPPSPMVKKQRRKKLT 839

  Fly   635 SSVKAN-------------------------EADDNDGYEFYIVSLDSKQWHFEAANSEERDEWV 674
            :..|..                         :|::|  :||.|||...:.||||||:.||||.||
Human   840 TPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEEN--FEFLIVSSTGQTWHFEAASFEERDAWV 902

  Fly   675 AAVEQEIFKSLQSIESSKTKQAT--STDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMC 737
            .|:|.:|..|||..||||.|..|  .::..|:.||| ...||..|||||||||.|||||||.|:|
Human   903 QAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIR-NAKGNSICVDCGAPNPTWASLNLGALIC 966

  Fly   738 IECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKE 802
            |||||:|||||:|:|:||||.|||||.....|:.||||..||.||||:||.|.||:..:|||::|
Human   967 IECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERE 1031

  Fly   803 RWVRSKYEAKEFLTPLGNGSSAHPSPSP-GQQLIEAVIRADIKSIVSILANCPSEVTNANVSARD 866
            .|:|:|||...||.||..      |..| |:||..||...|:.:::.:||:......:.:|....
Human  1032 SWIRAKYEQLLFLAPLST------SEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQ 1090

  Fly   867 VRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIK----AAAAAQA 927
            :|:||.||..:.::.|.|||:|.||::...|.:|||.|.|||.|.|...|..:.    ......|
Human  1091 LRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSA 1155

  Fly   928 GTTIPAPAPPTNGGIPAPQ 946
            .||..|...|:....|:|:
Human  1156 ATTPSAATTPSITATPSPR 1174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenG1ANP_723849.1 SelP_N <5..41 CDD:282453 3/6 (50%)
Centaurin_gamma 143..300 CDD:133303 89/158 (56%)
RAS 144..295 CDD:214541 86/152 (57%)
PH_AGAP 451..686 CDD:241281 92/269 (34%)
PH 454..>521 CDD:278594 41/66 (62%)
ArfGap 702..818 CDD:279720 72/115 (63%)
ANK <834..907 CDD:238125 24/72 (33%)
ANK repeat 834..866 CDD:293786 7/31 (23%)
Ank_5 859..907 CDD:290568 18/47 (38%)
ANK repeat 868..897 CDD:293786 12/28 (43%)
AGAP2NP_001116244.1 Interaction with EPB41L1. /evidence=ECO:0000250 1..23
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..377 15/90 (17%)
Interactions with HOMER1 and NF2. /evidence=ECO:0000250 180..225
Interaction with PLCG1. /evidence=ECO:0000250 267..390 19/106 (18%)
G domain 405..572 92/166 (55%)
small_GTPase 405..572 CDD:197466 92/166 (55%)
Centaurin_gamma 407..566 CDD:133303 89/158 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..619 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 634..673 13/86 (15%)
PH_AGAP 674..914 CDD:241281 92/269 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 769..854 19/86 (22%)
PH <845..909 CDD:278594 21/65 (32%)
ArfGap 933..1047 CDD:279720 72/114 (63%)
Ank_2 1058..1148 CDD:289560 30/89 (34%)
ANK 1058..>1147 CDD:238125 30/88 (34%)
ANK repeat 1058..1088 CDD:293786 7/29 (24%)
ANK repeat 1090..1121 CDD:293786 12/30 (40%)
ANK 1 1090..1119 12/28 (43%)
ANK 2 1123..1152 10/28 (36%)
ANK repeat 1123..1148 CDD:293786 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1192 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 217 1.000 Domainoid score I2673
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 747 1.000 Inparanoid score I586
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48005
OrthoDB 1 1.010 - - D480835at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41929
orthoMCL 1 0.900 - - OOG6_102626
Panther 1 1.100 - - O PTHR45819
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X686
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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