DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and ARAP1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001035207.1	Gene:	ARAP1 / 116985	HGNCID:	16925	Length:	1450	Species:	Homo sapiens

Alignment Length:	818	Identity:	182/818 - (22%)
Similarity:	285/818 - (34%)	Gaps:	241/818 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 QKILSQRLPLPPQVQPARP--TTPQGNRLGLAPYQAPTNGQRGQQ--QLPLRMSADFAQAEQKLW 358
            ::.|...|..|||.|...|  |.|||      |.|.|:......:  ..|:|:..:|..::.
Human   176 EESLLPSLSSPPQPQSEEPLSTLPQG------PPQPPSPPPCPPEIPPKPVRLFPEFDDSDY--- 231

  Fly   359 SLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRR 423
                         :.:.:..|||.       ::|..:          ||.|.|:..|...|.:..
Human   232 -------------DEVPEEGPGAP-------ARVMTK----------KEEPPPSRVPRAVRVASL 266

  Fly   424 RSNLFIPSSSKKADKEKE---------------------------PKSSELGSGRSIP----IKQ 457
            .|.....|...:.|:|::                           |...:...|.|.|    ||.
Human   267 LSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKA 331

  Fly   458 GYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTV-------KVPGQ 515
            |:|.|...:. :..::|::|.|..|     |....|...|.:.|    ::::|       .:..|
Human   332 GWLDKNPPQG-SYIYQKRWVRLDTD-----HLRYFDSNKDAYSK----RFISVACISHVAAIGDQ 386

  Fly   516 KPRGSKSIITNSALTSSLMANGQRAQNTL--SDGIGCLTLAKDNQRKLSEKLS--LLGAGSIAAG 576
            |    ..:|||:...:.      ||::.:  .:.:..|..|...||..:...|  |||.
Human   387 K----FEVITNNRTFAF------RAESDVERKEWMQALQQAMAEQRARARLSSAYLLGV------ 435

  Fly   577 AGGEPLKSNSSQQTSGDEG---IAMSNSNSQTFIAGEVANAG---NKLEAQTPNVKKRHRRMKSS 635
            .|.|......|.:..|.:.   :|:.....|.:...|..:.|   ..::....|||:..||
Human   436 PGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRR---- 496

  Fly   636 SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTD 700
                 ..|....|..:..|.||:.         |:::|:.|::..|.::|.:.|.::...|.:.
Human   497 -----SFDLTTPYRIFSFSADSEL---------EKEQWLEAMQGAIAEALSTSEVAERIWAAAP- 546

  Fly   701 LAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDD--WP 763
                         |.||.|||||.|:|||:||.|::|..|:|.||.||:.:||||||.:|.  |.
Human   547 -------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWT 598

  Fly   764 SPHLSVMLAIGNSLANSVWESNT--RQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHP 826
            ...:.:.|.:||...|..|.:|.  .:.::|:|..|..      |...|||     ...|.....
Human   599 ETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTR------RCHLEAK-----YREGKYRRY 652

  Fly   827 SPSPGQQ------LIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQL 885
            .|..|.|      |..||...|:....::| .|.:.: |......:..|||.||...|.....:.
Human   653 HPLFGNQEELDKALCAAVTTTDLAETQALL-GCGAGI-NCFSGDPEAPTPLALAEQAGQTLQMEF 715

  Fly   886 LIWNGAN-----------IKH-------TDHEG-----------------------RTC------ 903
            |..|...           .||       ..|.|                       |.|
Human   716 LRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGV 780

  Fly   904 LAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVEL-LEGLGCPEA 967
            |:|....:::.....|:|:..    ..:..|.|.|:|.    ::..|..|....| |.||...|.
Human   781 LSYFENERAVTPNGEIRASEI----VCLAVPPPDTHGF----EHTFEVYTEGERLYLFGLESAEQ 837

  Fly   968 A------------PLTASGTLPRRRDTLG-TPYEKSVS 992
            |            |..|...|.|..:.|| .||:..:|
Human   838 AHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLS 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	0/1 (0%)
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	53/255 (21%)
		PH	454..>521	CDD:278594	17/77 (22%)
		ArfGap	702..818	CDD:279720	43/119 (36%)
		ANK	<834..907	CDD:238125	22/119 (18%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	16/94 (17%)
		ANK repeat	868..897	CDD:293786	10/46 (22%)
ARAP1	NP_001035207.1	SAM_Arap1,2,3	6..68	CDD:188889
		SAM	10..64	CDD:197735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..144
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..302		31/164 (19%)
		PH	328..419	CDD:278594	23/110 (21%)
		PH1_ARAP	329..421	CDD:270073	23/111 (21%)
		PH2_ARAP	436..525	CDD:270074	21/106 (20%)
		ArfGap	535..651	CDD:279720	46/140 (33%)
		PH3_ARAP	743..849	CDD:270076	20/113 (18%)
		PH	744..848	CDD:278594	20/111 (18%)
		PH4_ARAP	862..952	CDD:270077	5/14 (36%)
		RhoGAP_ARAP	956..1135	CDD:239850
		RA	1172..1261	CDD:279168
		PH5_ARAP	1263..1402	CDD:270079
		PH	1299..1391	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810