DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and ARAP2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_056045.2	Gene:	ARAP2 / 116984	HGNCID:	16924	Length:	1704	Species:	Homo sapiens

Alignment Length:	1033	Identity:	199/1033 - (19%)
Similarity:	338/1033 - (32%)	Gaps:	379/1033 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 HPQQVHNQLQ-------------NPHQNQL-PPPQRHNHAAPTAAASASGAPSSSAS----ASAS 63
            |.:::..|||             |.|:.:. ..|.:..|           .|||..:    .|.|
Human    56 HRRRILKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYH-----------VPSSDQNICIELSNS 109

  Fly    64 ASILVAHPPQPLISNSLAIRQEIQRFE-SVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDS 127
            .|:..:.|||     ...:|:.::..: ||..|.|         |.:|.:::...||
Human   110 GSVQTSSPPQ-----LETVRKNLEDSDASVERSQY---------PQSDDKLSPPKRD-------- 152

  Fly   128 FVNSQEWTISRSVPDLRLG-----IVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQ 187
            |..::|       |.|.||     :.||.|....:|:.:......::|:..|..:...|
Human   153 FPTAEE-------PHLNLGSLNDSLFGSDNIKIESLITKKTVDHTVEEQQTEKVKLITE------ 204

  Fly   188 SYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDA 252
                                                              |..::|       :|
Human   205 --------------------------------------------------NLSKLP-------NA 212

  Fly   253 ISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPT 317
            .||                    |..:..|:|.|.|    ..:....:|.           ..|.
Human   213 DSE--------------------CLSFVGCSTSGTN----SGNGTNGLLE-----------GSPP 242

  Fly   318 TP----QGNRL------GLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKL----WSLQAASSSTI 368
            :|    ||..:      ..:|..||.   |.:.:|..|.|..|....:.:    .|.:..|.|..
Human   243 SPFFKFQGEMIVNDLYVPSSPILAPV---RSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVSGSYF 304

  Fly   369 NENNNI---TKYNPGAANSLQGDCSQV---------------QLRDPRDLAPPPGKELPTPTSTP 415
            .|..|:   |:.:....||.:.:.|.:               :.|..::.....|:.|....:|.
Human   305 RERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGEALKGEAATA 369

  Fly   416 TTS----------RKSR----RRSNLFIPSSSK----------------------------KADK 438
            |.|          ||.:    :..:::||...|                            ||.|
Human   370 TNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEECFQSLRRKNSKASK 434

  Fly   439 EKE--------------PKSSELGSGRSIPIKQ------GYLYKRSSKSLNKEWKKKYVTLCDDG 483
            .:.              |.||..|:..|..:..      ...|..|:|.:...|..|   |...|
Human   435 SRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDK---LSPQG 496

  Fly   484 RLTYHP----------SLHDYMDDVHGKE-IPLQYV-TVKVPGQKP------------RGSKSII 524
            :..:..          |.::...:::.|. |||..: ||:|.|...            |..|...
Human   497 KRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEE 561

  Fly   525 TNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKL----SEKLSLLGAGSIAAGAGGEPLKSN 585
            .|..:  |::.|..::|:..|.....:|..|....:|    ::..::|...|:......:..||
Human   562 RNDWI--SILLNALKSQSLTSQSQAVVTPEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKS- 623

  Fly   586 SSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEF 650
                     |:.:      |.|...||           |||:..|.:|.|              |
Human   624 ---------GLGI------TIIPMNVA-----------NVKQVDRTVKQS--------------F 648

  Fly   651 YIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRV---P 712
            .|:: ..:.:.|.|...:|:.:|:.||:|.|.::|...|                 :.:::   .
Human   649 EIIT-PYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYE-----------------VAEKIWFNE 695

  Fly   713 GNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDD--WPSPHLSVMLAIGN 775
            .|..|.||.||:|:|||:||.|::|.:|:|.||:||...||||||.:|.  |.:..:.:.:.|||
Human   696 SNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGN 760

  Fly   776 SLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIR 840
            ..||..|..|.::..:....:..|.::.::..||:..:|...|   .::.......:.|..||::
Human   761 KRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTL---LASLTKEELNKALCAAVVK 822

  Fly   841 ADIKSIVSILANCPSEVTNANVSARDV---------RTPLLLACAIGNLAIAQLLIWN 889
            .|:...:::|           .|..||         .||.|||...|.....:.|..|
Human   823 PDVLETMALL-----------FSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHN 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453	7/37 (19%)
		Centaurin_gamma	143..300	CDD:133303	20/161 (12%)
		RAS	144..295	CDD:214541	19/155 (12%)
		PH_AGAP	451..686	CDD:241281	52/268 (19%)
		PH	454..>521	CDD:278594	17/96 (18%)
		ArfGap	702..818	CDD:279720	39/120 (33%)
		ANK	<834..907	CDD:238125	16/65 (25%)
		ANK repeat	834..866	CDD:293786	6/31 (19%)
		Ank_5	859..907	CDD:290568	11/40 (28%)
		ANK repeat	868..897	CDD:293786	8/22 (36%)
ARAP2	NP_056045.2	SAM_Arap1,2,3	6..68	CDD:188889	4/11 (36%)
		SAM	13..65	CDD:197735	2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..161		11/58 (19%)
		PH1_ARAP	484..576	CDD:270073	18/96 (19%)
		PH	484..574	CDD:278594	18/94 (19%)
		PH	588..679	CDD:278594	26/132 (20%)
		PH2_ARAP	588..675	CDD:270074	24/128 (19%)
		ArfGap	686..801	CDD:279720	40/131 (31%)
		PH3_ARAP	892..1002	CDD:270076
		PH	921..998	CDD:278594
		PH4_ARAP	1015..1110	CDD:270077
		RhoGAP_ARAP	1114..1293	CDD:239850
		UBQ	1330..1417	CDD:294102
		PH5_ARAP	1423..1543	CDD:270079
		PH	1436..1537	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1675
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810