DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and ACAP3

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_011538908.1	Gene:	ACAP3 / 116983	HGNCID:	16754	Length:	844	Species:	Homo sapiens

Alignment Length:	908	Identity:	188/908 - (20%)
Similarity:	294/908 - (32%)	Gaps:	360/908 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 MILVGTQDAISERNPRVIDDTRARKLASDLKRC------SYYETCATYGLNVERVFQDACQKILS 302
            :.:.|.:|...:.....:...|.| |.||||.|      |..|.     :|...:..|..|:.:.
Human    56 LFVSGVRDLSQQCQGDTVISVRGR-LTSDLKECLQRFADSLQEV-----VNYHMILFDQAQRSVR 114

  Fly   303 QRLP--LPPQVQPARPTTPQGNRL-----------GLAPYQAPTNGQRGQQQLPL------RMSA 348
            |:|.  :...|:..:.|..|.:::           ..||...|...:.....|.|      .::.
Human   115 QQLQSFVKEDVRKFKETKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLAL 179

  Fly   349 DFA------QAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDP--RDLAPPPG 405
            |:.      ||::|...|           :::..:....::..|...|.:...||  :.||
Human   180 DYVLQINVLQAKKKFEIL-----------DSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLA---- 229

  Fly   406 KELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELG-SGRSIPIKQGYLYKRSSKSLN 469
            .||..........::...|.:..|...:...|...:....|.. ...|..:.:|||:||:|.:.
Human   230 AELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAF- 293

  Fly   470 KEWKKKYVTLCDDGRLTYHPSLHD----YMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALT 530
            |.|.:::.:: .:.:|.|...|.|    .:||            :::...||
Human   294 KTWNRRWFSI-QNSQLVYQKKLKDALTVVVDD------------LRLCSVKP------------- 332

  Fly   531 SSLMANGQRAQNTLSDGIGCLTLAKDNQRKLS-EKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDE 594
                                   .:|.:|:.. |.||              |.||
Human   333 -----------------------CEDIERRFCFEVLS--------------PTKS---------- 350

  Fly   595 GIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSSSVKANEADDNDGYEFYIVSLDSKQ 659
              .|..::|:                          :::.:.|:|.:|.....|.   .|.||
Human   351 --CMLQADSE--------------------------KLRQAWVQAVQASIASAYR---ESPDS-- 382

  Fly   660 WHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPN 724
                 ..||..|...:       .|..||:|:...:.......::|...|.|.||..|.|||.|:
Human   383 -----CYSERLDRTAS-------PSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPD 435

  Fly   725 PEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTR-- 787
            |.|||:|||||:||||||:||:||.|.||||||.||.|....|.:|..:|||..|.::|:...
Human   436 PRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGA 500

  Fly   788 -QRVKPTSQASREDKERWVRSKYEAKEFL--TPLGNGSSA----------HPSPSPGQQLIEAVI 839
             .| |||:.:||:|||.|::.||..|:||  .|:.....|          .|..||........:
Human   501 GSR-KPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKV 564

  Fly   840 RAD-IKSIVSILAN--------------CPSEV-------------------------------- 857
            |.: :...|:.|::              ||.|:
Human   565 RLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGS 629

  Fly   858 ---------------------------------TNAN-------------------VSARDV--- 867
                                             |.|.                   ..|||:
Human   630 SDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPAL 694

  Fly   868 -------------------RTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGR------------ 901
                               :|||:.|...|:|.:.:.|:.|||::...|..||
Human   695 AAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRT 759

  Fly   902 --TCLAYARAAQSLA--------TAKSIKAAAA-----------------AQAGTTIPAPAPP 937
              .||...|.|...|        .|.:::||.|                 |:|     ||.||
Human   760 GQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEA-----APGPP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	15/61 (25%)
		RAS	144..295	CDD:214541	13/56 (23%)
		PH_AGAP	451..686	CDD:241281	38/239 (16%)
		PH	454..>521	CDD:278594	16/70 (23%)
		ArfGap	702..818	CDD:279720	61/120 (51%)
		ANK	<834..907	CDD:238125	26/207 (13%)
		ANK repeat	834..866	CDD:293786	9/130 (7%)
		Ank_5	859..907	CDD:290568	19/102 (19%)
		ANK repeat	868..897	CDD:293786	10/28 (36%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:299863	34/185 (18%)
		PH	279..373	CDD:278594	29/195 (15%)
		PH_ACAP	281..377	CDD:270070	29/197 (15%)
		ArfGap	413..531	CDD:279720	61/118 (52%)
		ANK	711..>798	CDD:238125	22/86 (26%)
		ANK repeat	712..743	CDD:293786	10/30 (33%)
		Ank_4	715..766	CDD:290365	15/50 (30%)
		ANK repeat	745..776	CDD:293786	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850