DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and acap2

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_004914426.1	Gene:	acap2 / 100497437	XenbaseID:	XB-GENE-990716	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	758	Identity:	170/758 - (22%)
Similarity:	268/758 - (35%)	Gaps:	233/758 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 MSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPT 410
            :..|.|:.|.||..|.......|:........|....|.:            ||||....|:...
Frog    24 VEGDVAELEMKLDKLVKLCIGMIDAGKAFCAANKQFMNGI------------RDLAQYSSKDSVI 76

  Fly   411 PTST------------------PTTSRKSRRRSNLFIPSSSKK---ADKEKEPKSSELGSGRSIP 454
            .:|.                  ....|..:.:...|:....||   |.|:.:..|.|
Frog    77 ESSLTKFADSLQEMIKYHAMLFDQAQRSIKTQLQTFVKEDLKKFKDAKKQFDKVSEE-------- 133

  Fly   455 IKQGYLYKRSSKSLNKEWKKKYVT--LCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKP 517
             |:..|.|.:.....|:.:.:..|  |....:...|.:| ||:            :.:.|...|.
Frog   134 -KENALVKNAQAQRTKQHEVEEATNILVATRKCFRHIAL-DYV------------LQINVLQSKR 184

  Fly   518 RGS--KSIIT---------------NSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKL 565
            |..  ||:::               .|.|...:...|.:..|.:.|       |...:|.:..|.
Frog   185 RSEILKSMLSFMYAHLTFFHQGYDLFSELEPHMKDLGAQLDNLVGD-------AAKEKRDMEIKH 242

  Fly   566 SLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKR-- 628
            |.:.....|    .:..|...:..|:  .||.|     :.::....:||......:.|:..:|
Frog   243 STIQQKDFA----DDDTKLECNVDTT--SGIVM-----EGYLFKRASNAFKTWNRKKPDHTRRWF 296

  Fly   629 ---------HRRMKSS-----------SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEW 673
                     .::.|.:           :||..| |....:.|.:|| .:|....:|.:.:.|..|
Frog   297 SIQNNQLVYQKKFKDNPTVVVEDLRLCTVKPCE-DIERRFCFEVVS-PTKSCILQADSDKLRQAW 359

  Fly   674 VAAVEQEIF---------------KSLQSIES--SKTKQATSTDLAAMLAIRQRVPGNGFCVDCG 721
            :.||:..|.               |...||.|  |:||:......:|:..: |.:|||..|.|||
Frog   360 IKAVQTSIATAYREKGDEAEKAEKKPSVSITSPESETKENLVKGESALQRV-QCIPGNTNCCDCG 423

  Fly   722 APNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNT 786
            ..:|.|||:|||:.:||||||:||:||.|.||||||.||.|....|.:|..:||.:.||::|:..
Frog   424 LSDPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVMNSIYEARV 488

  Fly   787 RQR--VKPTSQASREDKERWVRSKYEAKEFLTPLGNGS----------------SAHP---SPS- 829
            .:.  .||.....|::||.::::||..|:|:....:.|                |:.|   :||
Frog   489 EKMGVRKPQHGCQRQEKEAYIKAKYVEKKFVDKYSDSSLMVYKRSPSLSKADRLSSEPLTRTPSK 553

  Fly   830 --------------------------------------------------------PGQQLIEAV 838
                                                                    ||.||.:|.
Frog   554 SSVKSNDSGIQFSAEVSREGLAVTASSNSLFDQDGEKKDDKQDSSAFQELNVKKLLPGPQLFQAS 618

  Fly   839 IRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTD------ 897
            ...::..:...||: .:||...|....:. |||:.|...|:|...:.|:.||||:.:.|
Frog   619 YEGNLPGMAEALAH-GAEVNWVNTKGNNA-TPLIQAVHGGSLVTCEFLLQNGANVNNRDIKGRGP 681

  Fly   898 --------HEGRTCLAYARAAQSLATAKSIK-----AAAAAQA 927
                    |.|:.||...|.|...|:.:..|     |..||.|
Frog   682 LHHATLLGHTGQVCLFLKRGANQHASDEDGKDPLTIAIDAANA 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	50/290 (17%)
		PH	454..>521	CDD:278594	13/70 (19%)
		ArfGap	702..818	CDD:279720	52/117 (44%)
		ANK	<834..907	CDD:238125	23/86 (27%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	17/61 (28%)
		ANK repeat	868..897	CDD:293786	11/28 (39%)
acap2	XP_004914426.1	BAR_ACAP2	18..217	CDD:153322	40/226 (18%)
		PH_ACAP	269..372	CDD:270070	20/109 (18%)
		ArfGap_ACAP2	404..519	CDD:350076	51/115 (44%)
		Ank_2	614..708	CDD:372319	26/95 (27%)
		ANK repeat	614..640	CDD:293786	6/26 (23%)
		ANK repeat	642..675	CDD:293786	11/33 (33%)
		ANK repeat	677..708	CDD:293786	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.040