DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and agap1

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_009300560.1	Gene:	agap1 / 100148154	ZFINID:	ZDB-GENE-130405-1	Length:	1255	Species:	Danio rerio

Alignment Length:	968	Identity:	417/968 - (43%)
Similarity:	550/968 - (56%)	Gaps:	164/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PSIYAIYE--LIDLLPMADAQIAQSIRDHV-VC-IEDSFVNSQEWTISRSVPDLRLGIVGSLNSG 154
            ||..|:.:  |:.....|:...:||..:.| .| ::|:||||||||:|||||:|::||||:|.||
Zfish   386 PSNRALRKNGLLGAQQRAEMGYSQSSSESVNGCPLDDAFVNSQEWTLSRSVPELKVGIVGNLASG 450

  Fly   155 KSALVHRYLTGSYMQEESPE-----GGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFV 214
            |||||||||||:|:||||||     |||||||:.:||||||||||||||.||.|||.||||||||
Zfish   451 KSALVHRYLTGTYVQEESPEADVDAGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFALWVDAVIFV 515

  Fly   215 FSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYY 279
            ||||:|.||.|||:||::||::||..|:|::|||||||||..|||||||||||||::|||||:||
Zfish   516 FSLEDEISFQTVYHYYSRMANYRNTAEVPLVLVGTQDAISAANPRVIDDTRARKLSNDLKRCTYY 580

  Fly   280 ETCATYGLNVERVFQDACQKILSQRLPLPPQVQPAR--PTTPQGNRLGLAPYQAPTNGQRGQQQL 342
            ||||||||||||||||..||:::.|......:.|.:  |.:|..:.:..||
Zfish   581 ETCATYGLNVERVFQDVAQKVVAIRKKQQLSIGPCKSLPNSPSHSSVCAAP-------------- 631

  Fly   343 PLRMSADFAQAEQKLWSLQAASSSTINENNN----ITKYNPGAANSLQGDCSQVQLRDPRDLAPP 403
                                .|:..|::|:|    ::.|:....::  ...||.:||
Zfish   632 --------------------VSAVHISQNSNGGGSLSDYSSSVPST--PSTSQKELR-------- 666

  Fly   404 PGKELPTPTSTPTTSRK-SRRRSNLFIPSSSKKADKEK---EPKSSELGSGRSIPIKQGYLYKRS 464
              .::|...:|||..|| |:||||||......:.|:||   :.::..:||||:||||||.|.|||
Zfish   667 --IDVPQTANTPTPVRKQSKRRSNLFTSRKGSEPDREKKGMDGRADSIGSGRAIPIKQGMLLKRS 729

  Fly   465 SKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQK-PRGSKSIITNSA 528
            .||||||||||||||||:|.|||||||||||.:||||||.|...||||||:: ||...:....|.
Zfish   730 GKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRAISTCAAPSP 794

  Fly   529 LTSSL---MANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQT 590
            .|:.|   |:|.|     |....|.:| :..:..:::..:||:...|...|........:|:.|.
Zfish   795 KTNGLTKDMSNMQ-----LGQAPGSVT-SSSSASQMASGISLVSFNSRPDGMHQRSYSVSSADQW 853

  Fly   591 SGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNV---------KKRHRRMKSSS---------- 636
            |....||.|..::.|.:...|.::.:.....:|.:         :|:|||.||:|
Zfish   854 SEATVIANSGISTDTGLGDSVCSSPSISSTTSPKMDPPPSPHANRKKHRRKKSTSNFKVDGFSGT 918

  Fly   637 ---------------------VKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQE 680
                                 ..:|..:..|.:||.||||..:.|:|||.:.||||.||.|:|.:
Zfish   919 AEAKHRAWKLNRVGSLRNIYNNSSNAEEQEDNFEFVIVSLTGQTWNFEATSYEERDAWVQAIESQ 983

  Fly   681 IFKSLQSIESSKTKQ--ATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGV 743
            |..||||.||||.|.  ::.::..|:.::| .:.||..||||.|.||:|||||||.|:||||||:
Zfish   984 ILASLQSCESSKQKSRLSSQSEAIALQSVR-NMRGNTRCVDCEAQNPDWASLNLGALICIECSGI 1047

  Fly   744 HRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSK 808
            |||||:|:|:||||.||:||...:.||.||||.|||||||:|.:.|:||...||||::|||:|:|
Zfish  1048 HRNLGTHLSRVRSLDLDEWPLELIKVMSAIGNELANSVWEANAQGRLKPAPDASREERERWIRAK 1112

  Fly   809 YEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLL 873
            ||.|.||..|     .....|.||||:.|....|::.:|.:||:...:..|......|.||.|.|
Zfish  1113 YEQKLFLASL-----TCTELSLGQQLLRATAEEDLRLVVILLAHGSRDEVNETCGEGDGRTALHL 1172

  Fly   874 ACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPT 938
            ||..||:.|.|||:|.|.:|...|....|.|||||.|.|
Zfish  1173 ACRKGNVVITQLLVWYGVDIMARDAHSNTALAYARQANS-------------------------- 1211

  Fly   939 NGGIPAPQYNVEDTTALVELLEGLGCP-EAAPLTASGTLPRRRDTLGTPYEKSVSGVI 995
                          ...:::|...||| |..||.|:..|.||.:..........|.||
Zfish  1212 --------------QECMDVLLQYGCPDERYPLMATPNLSRRNNNRNNSCSSMNSAVI 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	124/161 (77%)
		RAS	144..295	CDD:214541	120/155 (77%)
		PH_AGAP	451..686	CDD:241281	105/278 (38%)
		PH	454..>521	CDD:278594	52/67 (78%)
		ArfGap	702..818	CDD:279720	71/115 (62%)
		ANK	<834..907	CDD:238125	27/72 (38%)
		ANK repeat	834..866	CDD:293786	7/31 (23%)
		Ank_5	859..907	CDD:290568	21/47 (45%)
		ANK repeat	868..897	CDD:293786	15/28 (54%)
agap1	XP_009300560.1	Centaurin_gamma	439..601	CDD:133303	124/161 (77%)
		RAS	440..607	CDD:214541	125/166 (75%)
		PH_AGAP	716..989	CDD:241281	105/278 (38%)
		PH	719..>783	CDD:278594	50/63 (79%)
		PH	<933..984	CDD:278594	20/50 (40%)
		ArfGap	1008..1118	CDD:279720	69/110 (63%)
		Ank_2	1133..1223	CDD:289560	33/129 (26%)
		ANK	1133..>1222	CDD:238125	33/128 (26%)
		ANK repeat	1165..1196	CDD:293786	16/30 (53%)
		ANK repeat	1198..1223	CDD:293786	9/64 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2028
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56689
Inparanoid	1	1.050	735	1.000	Inparanoid score	I591
OMA	1	1.010	-	-		QHG48005
OrthoDB	1	1.010	-	-		D480835at33208
OrthoFinder	1	1.000	-	-		FOG0001514
OrthoInspector	1	1.000	-	-		otm25067
orthoMCL	1	0.900	-	-		OOG6_102626
Panther	1	1.100	-	-	LDO	PTHR45819
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870