DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenG1A and arhgap10

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_002933548.2	Gene:	arhgap10 / 100145146	XenbaseID:	XB-GENE-921747	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	79/408 - (19%)
Similarity:	124/408 - (30%)	Gaps:	123/408 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 IRDHVVCIEDSFVNSQEWTIS----------RSVP------DLRLGIVGSLNSGKSA-------- 157
            :.|...|.:....:|:||.:.          ||:|      :|....:....||...
Frog   432 LMDVKTCCDVDLDSSEEWEVKTVTSALKLYLRSLPEPLMTYELHDQFINPTKSGSPESRVNSIHH 496

  Fly   158 LVHRYLTGSYMQEESPEGGRFKKEVFI--------DGQSYLLLIRDEG--------GAPEMQFAG 206
            |:|:.          ||..|...::.|        ..:..|:.:.:.|        ...|...|.
Frog   497 LIHKL----------PEKNREMLDILITHLANVAHHAKKNLMTVANLGVVFGPTLMRPQEETVAA 551

  Fly   207 WVDA----VIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQD--AISERNPRVIDDTR 265
            .:|.    ::....:||....            |:|.   |..|....|  :||..|.......|
Frog   552 IMDLKFQNIVVEILIENHEKI------------FKNP---PSGLEAESDSSSISPPNAPPRQSRR 601

  Fly   266 ARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPP------QVQPARPTTPQGNRL 324
            .||           .....|.|::|   .|.....|:.|...|.      ..|...||||..|
Frog   602 HRK-----------RPVPVYDLSLE---LDNTDMNLTPREDTPTGSTDSLSPQSLTPTTPHTN-- 650

  Fly   325 GLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDC 389
                   .|..:|......:....|::.:|..:.|   ...|.||:.:......|.:
Frog   651 -------ATADERNHIMASIGGLVDWSASENLIHS---PLVSWINDESPAASTVPTS-------- 697

  Fly   390 SQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIP 454
               |..:|..:...|.:||..|..:.|||.|:..       ||:||..|...|..:|..|..|..
Frog   698 ---QAAEPAPVQQDPEEELTLPAHSLTTSDKAAE-------SSAKKKAKAVYPCEAEHSSELSFE 752

  Fly   455 IKQGYLYKRSSKSLNKEW 472
            :  |.:::....|....|
Frog   753 V--GAVFEDVHYSREPGW 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303	31/186 (17%)
		RAS	144..295	CDD:214541	29/180 (16%)
		PH_AGAP	451..686	CDD:241281	4/22 (18%)
		PH	454..>521	CDD:278594	3/19 (16%)
		ArfGap	702..818	CDD:279720
		ANK	<834..907	CDD:238125
		ANK repeat	834..866	CDD:293786
		Ank_5	859..907	CDD:290568
		ANK repeat	868..897	CDD:293786
arhgap10	XP_002933548.2	BAR_GRAF2	19..225	CDD:153319
		BAR-PH_GRAF_family	267..371	CDD:269953
		RhoGAP_Graf	367..568	CDD:239839	22/145 (15%)
		SH3_GRAF2	734..787	CDD:212998	8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910