DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenG1A and LOC100005008

DIOPT Version :9

Sequence 1:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_001344168.4	Gene:	LOC100005008 / 100005008	-ID:	-	Length:	958	Species:	Danio rerio

Alignment Length:	695	Identity:	156/695 - (22%)
Similarity:	255/695 - (36%)	Gaps:	215/695 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 LPLPPQVQPA-RPTT-----------PQGNRLGLAPYQAP---TNGQRGQQQLPLRMSADFAQAE 354
            :|.||.|.|. :|..           |...|.|.||...|   .|.|...|:..::..|....:
Zfish     3 VPGPPDVIPVPKPRAKYLFGKSLAQQPSIERNGDAPLPPPDVQINTQMKTQETDIQHEASVDGS- 66

  Fly   355 QKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKE-LPTPTSTPTTS 418
                |.|:.|:|.                             |.||......| |..|:|...:|
Zfish    67 ----SHQSTSASV-----------------------------PPDLLDVKSSETLVWPSSISISS 98

  Fly   419 RKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDG 483
            ..|        ..:.:.||.:..|.:|:.........|..:..:::||:
Zfish    99 GLS--------VEALRSADSDDSPAASDSPKTHQHLSKGQHNVQKASKT---------------- 139

  Fly   484 RLTYHPSLHDYMDDVH--GKEIPLQYVTV-KVPG--QKPRGSKSIITNSALTSSLMANGQRAQNT 543
                     |.:.||.  .:||.||..:: |:|.  :|||.:...::....|.|    ||::..|
Zfish   140 ---------DKLTDVQWANEEIHLQSESLQKMPDRPKKPRAATIRVSRKKQTLS----GQKSDQT 191

  Fly   544 LS-------------------------DGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLK 583
            .|                         || ..:::.|....|.:|  .:....|:
Zfish   192 RSEFTVSQSSWLDVWKGRKHMVLWATLDG-NLMSMWKKRTDKFTE--YVFHVASV---------- 243

  Fly   584 SNSSQQTSGDEGIAMSNSNSQTFIA-----------------GEVANAGNKLEAQTPNVKKRHRR 631
            :|.|:|..|...|.:...:.: |:|                 |..|.|..|..... ::|.|.::
Zfish   244 TNISKQEHGRFSIHLQKKHFE-FMAHNAAVQDGWLHSLYDSRGREAIAAPKKHGPL-SMKDRRKK 306

  Fly   632 MKSSS------VKANEADDNDGYEFYIVSLD-----------------SKQWHFEAANSEERDEW 673
            :.|:.      :.:::.|.|.|.....||::                 .:.::|.|.:|:|...|
Zfish   307 VYSAICGHSLWIYSSKEDFNLGLGMMCVSMNIASVKSTGRYGFSLITPYRTFNFSADSSKEASAW 371

  Fly   674 VAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIR-QRVPGNGFCVDCGAPNPEWASLNLGVLMC 737
            :.::...|..:|...|               :|:| ...|.|..|.||||.||||||:||.|::|
Zfish   372 LESLNDVIRNALSYSE---------------VALRLWSSPCNKVCADCGAANPEWASVNLLVVIC 421

  Fly   738 IECSGVHRNLGSHISKVRSLGLDD--WPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQ----A 796
            ..|:|.||::||..||||.|.|||  |..|.:.:.:..||..||:||..|    :.||.|    |
Zfish   422 EACAGAHRSMGSSRSKVRGLKLDDKVWTEPLIQLFVLHGNKTANNVWGHN----IPPTEQISPLA 482

  Fly   797 SREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSP----GQQLIEAVIRADIKSIVSILANCPSEV 857
            |.:.:..::.:||..       |....|||..:.    .|:|.|.|....::..||:|  |....
Zfish   483 SPDQRAEFILAKYHK-------GLYRKAHPLAASQKLLDQRLREVVCGPAVEETVSLL--CSGAK 538

  Fly   858 TNANVSARDVRTPLLLACAIGNLAIAQLLIWN----GANIKHTDH 898
            .:.:.|..::::.:.:|.:.|.....:||..|    ..:.:.|.|
Zfish   539 VSCSSSDPELKSAIAVAESAGQALQTELLRHNEFVEAPDFEQTRH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281	52/304 (17%)
		PH	454..>521	CDD:278594	15/71 (21%)
		ArfGap	702..818	CDD:279720	49/122 (40%)
		ANK	<834..907	CDD:238125	15/69 (22%)
		ANK repeat	834..866	CDD:293786	8/31 (26%)
		Ank_5	859..907	CDD:290568	8/44 (18%)
		ANK repeat	868..897	CDD:293786	5/32 (16%)
LOC100005008	XP_001344168.4	PH-like	291..375	CDD:302622	14/84 (17%)
		PH	292..380	CDD:278594	14/88 (16%)
		ArfGap	386..503	CDD:279720	51/142 (36%)
		RhoGAP	769..939	CDD:295372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810