DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGF1R and InR

DIOPT Version :9

Sequence 1:	XP_016877625.1	Gene:	IGF1R / 3480	HGNCID:	5465	Length:	1392	Species:	Homo sapiens
Sequence 2:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster

Alignment Length:	1477	Identity:	544/1477 - (36%)
Similarity:	782/1477 - (52%)	Gaps:	212/1477 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    46 IAQGLPETRIQVCG-----------------------PGIDIRNDYQQLKRLENCTVIEGYLHIL 87
            ||.||.:|.:.|.|                       ..:||||......:|||||||||:|.|.
  Fly   303 IADGLDKTALSVSGTQSRWTRSESNPTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLID 367

Human    88 LISKAEDY-RSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLK 151
            ||:.|... ||  |||||.:|:|::::||.||.||..:||||:||||.|||..||||::...:|.
  Fly   368 LINDASPLNRS--FPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLM 430

Human   152 DIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIV--GNKPPKECG-DLCPGTMEE 213
            |:||:.||:||||.:|||||..|||..|:||..||.......:|  .|...|||. ..|||.:..
  Fly   431 DLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRI 495

Human   214 KPMCEKTTINNEYNYR---------CWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDN 269
            :...:.|.|..|.|..         ||.:..||..||..| :..|.:.:.||..:|||.|....|
  Fly   496 EEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKC-RNNCIDEHTCCSQDCLGGCVIDKN 559

Human   270 -DTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECP 333
             :.:|::||:..:..:|:.:||...|:|:. |||..:.|..:...|::.....:.::|:|:..||
  Fly   560 GNESCISCRNVSFNNICMDSCPKGYYQFDS-RCVTANECITLTKFETNSVYSGIPYNGQCITHCP 623

Human   334 SGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGN--LLINIRR--GNN 394
            :|:.::.::.| |.||.|   ..|::|..:..|||:..|:...||||..|.  |.|:|:|  |.:
  Fly   624 TGYQKSENKRM-CEPCPG---GKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAH 684

Human   395 IASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGN-YSFYVLDNQNLQQLWD 458
            :..||:..:..:..:...:.:..::.|.||.|.::|..|.|:..::.: |:.|||||::|.:||.
  Fly   685 VMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWG 749

Human   459 WDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR-QSKGDINTRNNGERASCESDVLHFTS 522
             .::.:.|:.|.::|.||||||||.|.::..:..:|.: ..|.|:...:||.|.||.:.||:.|.
  Fly   750 -PNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTL 813

Human   523 TTTSKNRIIIT-------WHRYRP-------PDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNS 573
            .:...|..::.       ....:|       .|.|..|.|..|:...|:.|.|: ...|.| .:.
  Fly   814 QSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDR 876

Human   574 WNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSI 638
            |.   |..|....|   ::|..|.|:|.|:.||:    ||..:..:..|:|::...|||...||.
  Fly   877 WK---VSSPEKSGV---MVLSNLIPYTNYSYYVR----TMAISSELTNAESDVKNFRTNPGRPSK 931

Human   639 PLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQ--RQPQDGYLYRHN---YCSKDKIPIRKY 698
            ..:|::.:.|.|::.|.|:....|.|.|:.|.::.:  .:|.     |:|   ||::   |:.|.
  Fly   932 VTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPT-----RNNNRDYCTE---PLVKA 988

Human   699 ADGTIDIEEVTENPK-TEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKV-----FENFLHNSIFV 757
            .:.  |:...|...| ::...|:    |.|  .|..|:...:|.:.|||     |||.|.|.|||
  Fly   989 MEN--DLPATTPTKKISDPLAGD----CKC--VEGSKKTSSQEYDDRKVQAGMEFENALQNFIFV 1045

Human   758 P--------------------------------RPERKRRDVM------QVANTTMSSRSRNTT- 783
            |                                .|.|:||||.      .|..:.:....|:.|
  Fly  1046 PNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITD 1110

Human   784 ---------AADTYNITDPEELETEYPFFE----SRVDNKERTVISNLRPFTLYRIDIHSCNHE- 834
                     ..:||.  |.|:|.:...|:|    ....|:...|...||.||.|.|.:.:|..|
  Fly  1111 DTDAFFEKDDENTYK--DEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEI 1173

Human   835 -AEKLG--------CSASNFVFARTMPAEGAD---DIPGPVTWEPRPENSIFLKWPEPENPNGLI 887
             :|||.        ||..:.||..|...:.||   |:...:......|:.:.::|..|.:|||.|
  Fly  1174 PSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEI 1238

Human   888 LMYEIKYGSQVEDQ---RECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYV 949
            :.||:.|..|..||   ::|:...::.:..| .|.:||.|.|:.|::|.|::|.|.:|:.....|
  Fly  1239 VTYEVAYKLQKPDQVEEKKCIPAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKV 1302

Human   950 QAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVP 1014
            :....|......::.:.:| .|||.....:.|:..||..::.|.   :...|||  |.|:..|:|
  Fly  1303 EPPPSYAKVFFWLLGIGLA-FLIVSLFGYVCYLHKRKVPSNDLH---MNTEVNP--FYASMQYIP 1361

Human  1015 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVM 1079
            |:|||.||.|.....||||||||||||:.|....:..:...|||||||.|:.|||..||:|||||
  Fly  1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426

Human  1080 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA------------PP 1132
            |||:.:||||||||.|:|||.||:||||.:||||||||:.|||..:..::.            ||
  Fly  1427 KEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPP 1491

Human  1133 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1197
            :..::.|||.|||||||||.|.|||||||||||||||:|.||||||||||||||||||||||.||
  Fly  1492 TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKG 1556

Human  1198 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNC 1262
            |||||||.||||:|||:::.|||:||||||||:||||.|||||||||||||:|::||::::|:||
  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621

Human  1263 PDMLFELMRMCWQYNPKMRPSFLEIISSIKEEM-EPGFREVSFYYSE------ENKLPEPEELDL 1320
            ||.|.:||:.||.:....|||||:||:.::.:. ...|:|||||:||      |.:..|..:||.
  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDA 1686

Human  1321 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDE 1367
                ..:||||..       |.||.....|......|.....:|.|:
  Fly  1687 ----FAAVPLDQD-------LQDREQQEDATTPLRMGDYQQNSSLDQ 1722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGF1R	XP_016877625.1	None
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	63/110 (57%)
		Furin-like	512..645	CDD:279142	39/138 (28%)
		FU	545..592	CDD:238021	16/47 (34%)
		Recep_L_domain	663..781	CDD:279382	40/118 (34%)
		FN3	1224..1302	CDD:238020	25/78 (32%)
		PTKc_InsR_like	1364..1652	CDD:173625	186/287 (65%)
		Pkinase_Tyr	1371..1650	CDD:285015	181/278 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30997
Inparanoid	1	1.050	809	1.000	Inparanoid score	I488
Isobase	1	0.950	-	0	Normalized mean entropy	S4340
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm41905
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4609
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.960