DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGF1R and Sdr

DIOPT Version :9

Sequence 1:	XP_016877625.1	Gene:	IGF1R / 3480	HGNCID:	5465	Length:	1392	Species:	Homo sapiens
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	931	Identity:	257/931 - (27%)
Similarity:	402/931 - (43%)	Gaps:	220/931 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    39 LSCSAPWIAQGLPETRIQVCGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKL 103
            |..|:|.:|....:|   .|| .::| |....|::|:|||.:.|::.:..:...:...:|....|
  Fly    26 LGASSPVLASSDDQT---ACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSL 85

Human   104 ----TVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN-YALVIFEMTNLKDIGLYNLRNITR 163
                |.|::||:::|..||.||..:||.|.:|||.:|.:: |:||::|..||:::||..|..|..
  Fly    86 ASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQS 150

Human   164 GAIRIEKNADLCYLSTVDWSLILDAVSNNY--IVGNKPPKECGDLCPGTMEEKPMCEKTTINNEY 226
            |.||:|.|..||::.||||..::...:..:  :..|:|..:|           |:|...:.:.|:
  Fly   151 GFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSLSADFEF 204

Human   227 ----NYRCWTTNRCQ--------KMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHY 279
                :.|||..|..|        |.||..||...|....:||...|:..|.:.:    |..|.:|
  Fly   205 IRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CSLCANY 265

Human   280 YYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFV--IHDGECMQECPSGFIRNGSQ 342
            .....||..|.. :|.....||:....|..:         |.:  |...:|:::||      |:|
  Fly   266 QGRMGCVNQCVA-SYELNKRRCIGHRECREL---------GRIPLIRGYQCVKKCP------GNQ 314

Human   343 S--------MYC-IPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL---LINIRRGNNI 395
            .        ::| :.|.|..           .:.|....::||.|....|:|   |.||:  ..|
  Fly   315 KEILVAKGIIHCQVECNGDF-----------HVKSAADLEVLQDCVTINGSLTIELTNIK--EKI 366

Human   396 ASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWD 460
            ...|||.:..::.:|||:|:.||..|:||:||:||..|.|::.:|..|:.||::|.:|:.:|..:
  Fly   367 VDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPN 431

Human   461 HRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTT 525
            |. :.|:.|.::|..||:||..:|::::....:....|..|::..:||||..|...|........
  Fly   432 HL-VIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKVE 495

Human   526 SKN----RIIITWHRYRPPDYRD------LISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVD 580
            ..|    |||:        ||.|      ||.::.:|||||.:|||.|||:..||.::|.|   |
  Fly   496 DLNSTAVRIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLM---D 549

Human   581 LPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR-GAKSEILYIRTNASVPSIPLDVLS 644
            :.||:....  ::.||||:||||.:||  |||..|. ||: .|.|:|.|.:|....||..|.:..
  Fly   550 VVPNQSRRH--VISGLKPYTQYAYFVK--TLTRTEY-HIQIDAYSKIGYFQTLPDRPSPVLRIYG 609

Human   645 ASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVT 709
            :|..|||:::.|.||..|||.:..|.|..::       |.....:|||..:....:...||:
  Fly   610 SSEISSQILLHWWPPRRPNGVIKNYFVTAEK-------YNATKEAKDKNYVNVELENAKDID--- 664

Human   710 ENPKTEVCGGEKGPCCAC---------PKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRR 765
                           |.|         |:.:.|....||:..|    |:.|.|.|:|.|....||
  Fly   665 ---------------CECAGVLPYYSGPQPDDEDYYNKEQITY----EDALPNLIYVSRNHDYRR 710

Human   766 ----------DVMQVANTTMSSRSRNTTAADTYNITDPEELET-EYPFFESRVDNKERTV----- 814
                      .::.:......:|...||.|.|......|.|.. .|..:....:.|:|.:
  Fly   711 KEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRLNSEKKQRDLQDLDQ 775

Human   815 ----------------------------------------------ISNLRPFTLYRIDIHSCNH 833
                                                          :|.|.|.|.|||.|.:| .
  Fly   776 HKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-V 839

Human   834 EAEKLGCSASNFVFARTMPAE 854
            |....|||.         |||
  Fly   840 EGVVNGCST---------PAE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGF1R	XP_016877625.1	None
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	43/114 (38%)
		Furin-like	209..332	CDD:279142	34/142 (24%)
		Recep_L_domain	347..461	CDD:279382	41/116 (35%)
		FN3	491..578	CDD:214495	39/101 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870