Protein Alignment APOE and apoe

DIOPT Version :10

• Sequence 1: NP_001289617.1
• Gene: APOE / 348
• HGNCID: 613
• Length: 343
• Species: Homo sapiens
• Sequence 2: XP_002941085.2
• Gene: apoe / 394678
• XenbaseID: XB-GENE-853213
• Length: 275
• Species: Xenopus tropicalis
• Alignment Length: 304
• Identity: 75/304 - (24%)
• Similarity: 161/304 - (52%)
• Gaps: 36/304 - (11%)

Human    27 MKVLWAALLVTFLAGCQAK--VEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSE 89
            ||::...|.:..|||.||:  ...|.:|                :||.||..||..:..::..::
 Frog     1 MKLMILLLTLGLLAGAQARSLFRDAPKT----------------KWETALDSFWLTVNKMEEAAD 49

Human    90 QVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMED 154
            :.:.::..|.:::||..|:.:||:||..|..:::.:::|:|::.:.|.::|:.|...:|.:||||
 Frog    50 EARAKMKDSPISKELDGLIKDTMEELSIYAEDMKSKVSPMAQDAQQRFTEEVSALADKLKSDMED 114

Human   155 VCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLS 219
            ...:.:||.|:::.|..|:.|:::.::..:::||:|||.:|::||:|:|:.|....|:..|..:.
 Frog   115 TKNKAIQYSGDLRMMFDQNIEDVQGKVNMYMKKLKKRLSKDSEDLKKKLSQYGEDFRKSTEDKVE 179

Human   220 AIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVR 284
            .:|:.:.|.:..               ::::.|.....|:..::|.|.:.|||...|.:   :.:
 Frog   180 NLRKAVEPYLSN---------------VKDKGQQRLMNLKDAIDEQGKQLRDRFVSVAK---DAQ 226

Human   285 AKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQ 328
            ||:::.|..::...:....:.:.||.|.||.::.|...|.:.:|
 Frog   227 AKMKKTASDVKSSVDKLGEQFRKWFNPNVESLRNQLQALAKSLQ 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APOE	NP_001289617.1	Apolipoprotein	107..292	CDD:460211	47/184 (26%)
apoe	XP_002941085.2	Apolipoprotein	67..241	CDD:460211	48/191 (25%)