Protein Alignment APOE and apoeb

DIOPT Version :10

• Sequence 1: NP_001289617.1
• Gene: APOE / 348
• HGNCID: 613
• Length: 343
• Species: Homo sapiens
• Sequence 2: NP_571173.1
• Gene: apoeb / 30314
• ZFINID: ZDB-GENE-980526-368
• Length: 281
• Species: Danio rerio
• Alignment Length: 310
• Identity: 88/310 - (28%)
• Similarity: 163/310 - (52%)
• Gaps: 37/310 - (11%)

Human    29 VLWAALLVTFLAGCQAK-VEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQ 92
            |::.||.|  |.||||: :.||  ..|:|            |||..:.|||.|:..:.|.::.:.
Zfish     5 VVFFALAV--LTGCQARSLFQA--DAPQP------------RWEEMVDRFWQYVSELNTQTDGMV 53

Human    93 EELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCG 157
            :.:..||:::||..|:.:||.||.:|...|:.|:||.|.:...:|||:||....:|..||.|...
Zfish    54 QNIKGSQLSRELDTLITDTMAELSSYSENLQTQMTPYASDAAGQLSKDLQLLAGKLQTDMTDAKE 118

Human   158 RLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIR 222
            |..||..|::.|:.|:.::::.|:.::.|||:|||.:|.::::..:|.|.:..:..|.:...|::
Zfish   119 RSTQYLQELKTMMEQNADDVKNRVGTYTRKLKKRLNKDTEEIRNTVATYMSEMQSRASQNADAVK 183

Human   223 ERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKL 287
            :|..|.:.|.:..|.           ::..|..|.::|:.:|:.       ::::.|...::.||
Zfish   184 DRFQPYMSQAQDGAT-----------QKLGAISELMKAQAQEVS-------EQLEVQAGALKEKL 230

Human   288 EEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAP 337
            ||.|:.:|...|.....|.|...|..:.::.|...:::|::.|  |:|.|
Zfish   231 EETAENLRTSLEGRVDELTSLLAPYSQKIREQLQEVMDKIKEA--TAALP 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APOE	NP_001289617.1	Apolipoprotein	107..292	CDD:460211	51/184 (28%)
apoeb	NP_571173.1	3 X approximate tandem repeats	34..66		8/31 (26%)
		9 X 22 AA approximate tandem repeats	67..281		63/232 (27%)
		Apolipoprotein	68..242	CDD:460211	53/191 (28%)