DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment APOE and Apoe

DIOPT Version :10

Sequence 1:NP_001289617.1 Gene:APOE / 348 HGNCID:613 Length:343 Species:Homo sapiens
Sequence 2:NP_620183.2 Gene:Apoe / 25728 RGDID:2138 Length:312 Species:Rattus norvegicus


Alignment Length:319 Identity:223/319 - (69%)
Similarity:260/319 - (81%) Gaps:11/319 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    27 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQV 91
            ||.|||.|||..|.||.|        |.|.|:..|...||.|.||.||.|||||||||||||:||
  Rat     1 MKALWALLLVPLLTGCLA--------EGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQV 57

Human    92 QEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVC 156
            ||||.||||||||..||::||.|:||||.||||||.||||||||||:||:|||||||||||||:.
  Rat    58 QEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLR 122

Human   157 GRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAI 221
            .||.|||.||..||||||||||.||::||||:||||:|||||||||||||:|||:||||||:|||
  Rat   123 NRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAI 187

Human   222 RERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK 286
            ||||||||||||.|.|.:|:.|.|||::||||..:|:|.|:||:|::.||||:||:||:.|||:|
  Rat   188 RERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSK 252

Human   287 LEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGT---SAAPVPSDN 342
            :|||.||||||||.||||:|.||||||||||||||.|:||:||:|.|   ::..||.:|
  Rat   253 MEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIASTTVPLEN 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APOENP_001289617.1 Apolipoprotein 107..292 CDD:460211 136/184 (74%)
ApoeNP_620183.2 8 X 22 AA approximate tandem repeats 72..247 129/174 (74%)
Apolipoprotein 73..258 CDD:460211 136/184 (74%)
LDL and other lipoprotein receptors binding. /evidence=ECO:0000250|UniProtKB:P02649 150..160 8/9 (89%)
LDL receptor binding. /evidence=ECO:0000250|UniProtKB:P02649 150..160 8/9 (89%)
Lipid-binding and lipoprotein association. /evidence=ECO:0000250|UniProtKB:P02649 202..282 51/79 (65%)
Homooligomerization. /evidence=ECO:0000250|UniProtKB:P02649 258..312 37/54 (69%)
Specificity for association with VLDL. /evidence=ECO:0000250|UniProtKB:P02649 270..282 9/11 (82%)

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