DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment APOE and Apoe

DIOPT Version :10

Sequence 1:NP_001289617.1 Gene:APOE / 348 HGNCID:613 Length:343 Species:Homo sapiens
Sequence 2:NP_033826.2 Gene:Apoe / 11816 MGIID:88057 Length:311 Species:Mus musculus


Alignment Length:318 Identity:226/318 - (71%)
Similarity:263/318 - (82%) Gaps:10/318 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    27 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQV 91
            ||.|||.||||.|.||.|        |.|||:..|.||||.|.||.||.|||||||||||||:||
Mouse     1 MKALWAVLLVTLLTGCLA--------EGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQV 57

Human    92 QEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVC 156
            ||||.||||||||.|||::||.|:||||.||||||.||||||||||.||:|||||||||||||:.
Mouse    58 QEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLR 122

Human   157 GRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAI 221
            .||.|||.||..||||||||:|.||::||||:||||:|||:|||||||||:||||||||||:|||
Mouse   123 NRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAI 187

Human   222 RERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK 286
            ||||||||||||.|.|.:|:.|.|||::||||:|:|:|.|:||:|::.||||:||:|.:.|||:|
Mouse   188 RERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSK 252

Human   287 LEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTS--AAPVPSDN 342
            :|||.||||||||.||||||.||||:||||.||||.|:||:||:|.|:  ..||..:|
Mouse   253 MEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIITPVAQEN 310

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APOENP_001289617.1 Apolipoprotein 107..292 CDD:460211 135/184 (73%)
ApoeNP_033826.2 8 X 22 AA approximate tandem repeats 72..247 129/174 (74%)
Apolipoprotein 73..258 CDD:460211 135/184 (73%)
LDL and other lipoprotein receptors binding. /evidence=ECO:0000250|UniProtKB:P02649 150..160 8/9 (89%)
Lipid-binding and lipoprotein association. /evidence=ECO:0000250|UniProtKB:P02649 202..282 51/79 (65%)
Homooligomerization. /evidence=ECO:0000250|UniProtKB:P02649 258..311 36/53 (68%)
Specificity for association with VLDL. /evidence=ECO:0000250|UniProtKB:P02649 270..282 9/11 (82%)

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