DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpII33 and RPB3

DIOPT Version :9

Sequence 1:	NP_477419.1	Gene:	RpII33 / 34796	FlyBaseID:	FBgn0026373	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_012243.3	Gene:	RPB3 / 854791	SGDID:	S000001283	Length:	318	Species:	Saccharomyces cerevisiae

Alignment Length:	274	Identity:	128/274 - (46%)
Similarity:	176/274 - (64%)	Gaps:	14/274 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLAHRIGLI 71
            |.|:|.|.:.|||.|:|.:.:|::|||||||.|||.||||||.|::|.|:|||:|||:|||:|||
Yeast     6 PQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLI 70

  Fly    72 PLISDDVVERLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADLKSSNAKVLPVTSRNQG 136
            ||.|.| :|:|:|:|||.|.|.|.:|||..||......|.|.:|.:.||    ..|..:..||.|
Yeast    71 PLQSMD-IEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDL----VIVSNLMGRNIG 130

  Fly   137 EEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDPDNSMRHTLY--- 198
            ....:..|.|. :||.||||||||||...||||..||||||.|.|.:.|||||.|.::||.|
Yeast   131 HPIIQDKEGNG-VLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYE 194

  Fly   199 -PKPDEWPKSEHTELEDDQYEA-PYNWEAKPNKFFFNVESAGALKPENIVVMGVQVLKNKLSNL- 260
             ....|||:|::.|.||...|. |::::|:.:.|:.||||.|::..:.:||.|:..|:.|::::
Yeast   195 QDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQKKVASIL 259

  Fly   261 --QTQLSHESQNDA 272
              .||:..:..|.|
Yeast   260 LALTQMDQDKVNFA 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII33	NP_477419.1	RNAP_II_RPB3	7..267	CDD:132909	126/267 (47%)
RpII33	NP_477419.1	RPOLD	19..261	CDD:214766	118/249 (47%)
RPB3	NP_012243.3	RNAP_II_RPB3	6..265	CDD:132909	125/264 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346285
Domainoid	1	1.000	214	1.000	Domainoid score	I485
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2017
Inparanoid	1	1.050	231	1.000	Inparanoid score	I727
Isobase	1	0.950	-	0	Normalized mean entropy	S681
OMA	1	1.010	-	-		QHG53541
OrthoFinder	1	1.000	-	-		FOG0004444
OrthoInspector	1	1.000	-	-		oto99418
orthoMCL	1	0.900	-	-		OOG6_101363
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1185
SonicParanoid	1	1.000	-	-		X3150
TreeFam	1	0.960	-	-
	16	15.740