DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpII33 and Polr2c

DIOPT Version :9

Sequence 1:	NP_477419.1	Gene:	RpII33 / 34796	FlyBaseID:	FBgn0026373	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001012491.1	Gene:	Polr2c / 361365	RGDID:	1306935	Length:	275	Species:	Rattus norvegicus

Alignment Length:	275	Identity:	188/275 - (68%)
Similarity:	244/275 - (88%)	Gaps:	1/275 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPYANQPSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLA 65
            |||||||:|:|||||::||||::|:|:|:||||:|||||||.|.:||||||::|||:||.|||:|
  Rat     1 MPYANQPTVRITELTEENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIA 65

  Fly    66 HRIGLIPLISDDVVERLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADLKSSNAKVLPV 130
            ||:|||||.|||:|::|||:|||.|.:|||||||||||||:|:|:||||||:.||.|::.:|:||
  Rat    66 HRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPV 130

  Fly   131 TSRNQGEEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDPDNSMRH 195
            ||||:..:.|:|.| .|:|||:||||||||:||||||||||||||||||||||.|||||||::||
  Rat   131 TSRNRDNDPNDYVE-QDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRH 194

  Fly   196 TLYPKPDEWPKSEHTELEDDQYEAPYNWEAKPNKFFFNVESAGALKPENIVVMGVQVLKNKLSNL 260
            |:||||:||||||::||::|:.:|||:...||.:|::||||.|:|:||.||:..:..||.|||:|
  Rat   195 TVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDL 259

  Fly   261 QTQLSHESQNDALAV 275
            |||||||.|:|.|.:
  Rat   260 QTQLSHEIQSDVLTI 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII33	NP_477419.1	RNAP_II_RPB3	7..267	CDD:132909	177/259 (68%)
RpII33	NP_477419.1	RPOLD	19..261	CDD:214766	163/241 (68%)
Polr2c	NP_001012491.1	RNAP_II_RPB3	7..266	CDD:132909	177/259 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353262
Domainoid	1	1.000	358	1.000	Domainoid score	I938
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2017
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1776
OMA	1	1.010	-	-		QHG53541
OrthoDB	1	1.010	-	-		D424392at33208
OrthoFinder	1	1.000	-	-		FOG0004444
OrthoInspector	1	1.000	-	-		oto96599
orthoMCL	1	0.900	-	-		OOG6_101363
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3150
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810