DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpII33 and polr2c

DIOPT Version :9

Sequence 1:	NP_477419.1	Gene:	RpII33 / 34796	FlyBaseID:	FBgn0026373	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001161428.1	Gene:	polr2c / 334669	ZFINID:	ZDB-GENE-030131-6609	Length:	275	Species:	Danio rerio

Alignment Length:	275	Identity:	184/275 - (66%)
Similarity:	241/275 - (87%)	Gaps:	1/275 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPYANQPSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLA 65
            |||||||:|:||||:|:|||||:|:|:|:||||:||||::|.||:||||||::|||:||.|||:|
Zfish     1 MPYANQPTVKITELSDENVKFVIENTDLAVANSIRRVFMSEVPTIAIDWVQIDANSSVLHDEFVA 65

  Fly    66 HRIGLIPLISDDVVERLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADLKSSNAKVLPV 130
            ||:|||||.|||:|:::||:|||.|.|||||||||.||||:|:|:||||||:.||.|:|.:|:||
Zfish    66 HRVGLIPLTSDDIVDKMQYSRDCTCDDFCPECSVELTLDVRCTEDQTRHVTSRDLLSNNPRVIPV 130

  Fly   131 TSRNQGEEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDPDNSMRH 195
            |||::..:.|:|.| .|:||::||||||||:||||||||||||||||||||||.|||||||::||
Zfish   131 TSRSRDNDPNDYVE-QDDILLVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRH 194

  Fly   196 TLYPKPDEWPKSEHTELEDDQYEAPYNWEAKPNKFFFNVESAGALKPENIVVMGVQVLKNKLSNL 260
            |:||.|.||||||::|:|:|..:|.|:...||.:|::||||.|:|:||.||:..:.:||.|||:|
Zfish   195 TVYPIPQEWPKSEYSEIEEDGVQAQYDPNGKPERFYYNVESCGSLRPETIVMSALAMLKKKLSDL 259

  Fly   261 QTQLSHESQNDALAV 275
            |||||||.|:|.|.:
Zfish   260 QTQLSHEIQSDVLTI 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII33	NP_477419.1	RNAP_II_RPB3	7..267	CDD:132909	173/259 (67%)
RpII33	NP_477419.1	RPOLD	19..261	CDD:214766	159/241 (66%)
polr2c	NP_001161428.1	RNAP_II_RPB3	7..266	CDD:132909	173/259 (67%)
polr2c	NP_001161428.1	RPOLD	19..260	CDD:214766	159/241 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595361
Domainoid	1	1.000	349	1.000	Domainoid score	I987
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2017
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1866
OMA	1	1.010	-	-		QHG53541
OrthoDB	1	1.010	-	-		D424392at33208
OrthoFinder	1	1.000	-	-		FOG0004444
OrthoInspector	1	1.000	-	-		oto39835
orthoMCL	1	0.900	-	-		OOG6_101363
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1185
SonicParanoid	1	1.000	-	-		X3150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800