DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpII33 and rpb3

DIOPT Version :9

Sequence 1:	NP_477419.1	Gene:	RpII33 / 34796	FlyBaseID:	FBgn0026373	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_588324.1	Gene:	rpb3 / 2538816	PomBaseID:	SPCC1442.10c	Length:	297	Species:	Schizosaccharomyces pombe

Alignment Length:	276	Identity:	119/276 - (43%)
Similarity:	177/276 - (64%)	Gaps:	25/276 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NQPSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLAHRIG 69
            ::..:.|..::.::|.|||.:|.|:||||||||.:||.||:|||.|::..|::|:.|||||||:|
pombe     3 SETHITIRNISKNSVDFVLTNTSLAVANSLRRVVLAEIPTVAIDLVEINVNTSVMPDEFLAHRLG 67

  Fly    70 LIPLISDDVVE----RLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADL-KSSNAKV-L 128
            :|||.|.::.|    .|:|||:|.|..:||:||||..|:.||:.|.|..:...|| .|||:.: .
pombe    68 MIPLDSSNIDEPPPVGLEYTRNCDCDQYCPKCSVELFLNAKCTGEGTMEIYARDLVVSSNSSLGH 132

  Fly   129 PVTS--RNQGEEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDPDN 191
            |:.:  :::|.            ||.||||.||:.||..||||..||||||:||:.|.|||||.|
pombe   133 PILADPKSRGP------------LICKLRKEQEISLRCIAKKGIAKEHAKWSPTSAVAFEYDPWN 185

  Fly   192 SMRHTLY----PKPDEWPKSEHTELEDDQYEA-PYNWEAKPNKFFFNVESAGALKPENIVVMGVQ 251
            .::||.|    ....|||||::.:.|:...|. |:|::.:|.:|:.:|||.|::.|..|:|.|::
pombe   186 KLQHTDYWFENDADAEWPKSKNADWEEPPREGEPFNFQEEPRRFYMDVESVGSIPPNEIMVQGLR 250

  Fly   252 VLKNKLSNLQTQLSHE 267
            :|:.||:.|...|..|
pombe   251 ILQEKLAVLVRDLDEE 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII33	NP_477419.1	RNAP_II_RPB3	7..267	CDD:132909	118/272 (43%)
RpII33	NP_477419.1	RPOLD	19..261	CDD:214766	115/254 (45%)
rpb3	NP_588324.1	RNAP_II_RPB3	6..266	CDD:132909	118/271 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	209	1.000	Domainoid score	I611
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2017
Inparanoid	1	1.050	217	1.000	Inparanoid score	I922
OMA	1	1.010	-	-		QHG53541
OrthoFinder	1	1.000	-	-		FOG0004444
OrthoInspector	1	1.000	-	-		oto101010
orthoMCL	1	0.900	-	-		OOG6_101363
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1185
SonicParanoid	1	1.000	-	-		X3150
TreeFam	1	0.960	-	-
	14	13.860