DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpII33 and rpb-3

DIOPT Version :9

Sequence 1:	NP_477419.1	Gene:	RpII33 / 34796	FlyBaseID:	FBgn0026373	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_492361.2	Gene:	rpb-3 / 172680	WormBaseID:	WBGene00007971	Length:	282	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	162/280 - (57%)
Similarity:	209/280 - (74%)	Gaps:	9/280 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPYANQPSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLA 65
            |||||||::::||||:|.:||||.||:|||||||||||:||.||:||||||:|.|::||.|||:|
Worm     1 MPYANQPNIEVTELTNDIIKFVLWDTDLSVANSLRRVFMAEVPTIAIDWVQIETNTSVLHDEFIA 65

  Fly    66 HRIGLIPLISDDVVERLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADL---KSSNAKV 127
            ||:||||.|||..||::||||||.|.:||.|||:.|.|.:||.:|.|..|||..|   .:.:..|
Worm    66 HRMGLIPFISDYHVEKMQYTRDCECAEFCDECSIPFILQMKCKDEATLAVTTEHLMPMHNLDTTV 130

  Fly   128 LPVTS---RNQGEEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDP 189
            .|...   |.:|...:|: .:.:||||:||||||||.|:||.||||||||||||||.||.|||||
Worm   131 RPACGKALRERGSTRDEF-HNREEILIVKLRKGQELNLKAYVKKGFGKEHAKWNPTCGVAFEYDP 194

  Fly   190 DNSMRHTLYPKPDEWPKSEHTELEDD--QYEAPYNWEAKPNKFFFNVESAGALKPENIVVMGVQV 252
            ||::|||:||..:|||:|:|:.|.:|  :.|||:..:.|||||:|::|..|||..:.||.||:.:
Worm   195 DNALRHTIYPNVEEWPRSDHSSLPEDSTEKEAPFEPDNKPNKFWFSIEGTGALPAQRIVTMGIGI 259

  Fly   253 LKNKLSNLQTQLSHESQNDA 272
            ||.||..|...||:|.|..|
Worm   260 LKRKLEELNMALSNELQAHA 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII33	NP_477419.1	RNAP_II_RPB3	7..267	CDD:132909	153/267 (57%)
RpII33	NP_477419.1	RPOLD	19..261	CDD:214766	144/249 (58%)
rpb-3	NP_492361.2	RNAP_II_RPB3	7..274	CDD:132909	153/267 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166820
Domainoid	1	1.000	295	1.000	Domainoid score	I806
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2017
Inparanoid	1	1.050	332	1.000	Inparanoid score	I1429
Isobase	1	0.950	-	0	Normalized mean entropy	S681
OMA	1	1.010	-	-		QHG53541
OrthoDB	1	1.010	-	-		D424392at33208
OrthoFinder	1	1.000	-	-		FOG0004444
OrthoInspector	1	1.000	-	-		oto20360
orthoMCL	1	0.900	-	-		OOG6_101363
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1185
SonicParanoid	1	1.000	-	-		X3150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750