Protein Alignment Orc5 and ORC5

DIOPT Version :9

• Sequence 1: NP_477132.1
• Gene: Orc5 / 34794
• FlyBaseID: FBgn0015271
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_014138.1
• Gene: ORC5 / 855460
• SGDID: S000005205
• Length: 479
• Species: Saccharomyces cerevisiae
• Alignment Length: 511
• Identity: 114/511 - (22%)
• Similarity: 209/511 - (40%)
• Gaps: 112/511 - (21%)

  Fly    15 REAAIETLGELIGDSSETYPSAIYLFGHSGTGKTALTRAFLKECGKRQNVRTAHLNAIECYTTKI 79
            ||.....|...|....:..||.:.|.|:||||||...:.:.   ....|:....|..:|..:.|.
Yeast    11 REYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYF---NANPNLHAVWLEPVELVSWKP 72

  Fly    80 MLEIL-------LDSLAPD----QGDALKVDNMLDFVEQLRR---QAATRVEDQGFLIAVDNAER 130
            :|:.:       |.:|.|:    ..|.|:|:.....|:.|..   |..:..|.....:.:|..:.
Yeast    73 LLQAIARTVQYKLKTLYPNIPTTDYDPLQVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDS 137

  Fly   131 LRDMDANVLPVLLRLQEL----TNLNL-CVILLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQR 190
            |:|:||.:....::|.||    :.:|: .:..:.:..|.:.|:...:..::   ..:||..|...
Yeast   138 LQDLDAALFNKYIKLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVM---FPRYNVDEVST 199

  Fly   191 ILGSDFQQVRNQLLEQFAQDKKRLEICQEAVT----EDFYN---NYLNLFLSVFYKACRDVPELQ 248
            ||      |.::..|.......|..|.:|.:|    :.|.|   |:::|.:..|:
Yeast   200 IL------VMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFIHLIVQAFH---------- 248

  Fly   249 LTARKCLSTYLEPVLDGTVDATD------ISRLWR-HIAGPL---RSALTQIYMRIEKPAEEVED 303
                    :|....:....|..|      :||:.: :|..||   :||:.......:..:|..:.
Yeast   249 --------SYTGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLSENGQG 305

  Fly   304 FTAI-EDQSVRKLAQSLELPYYAKFLLIAAFLASHNAAKQDKRLFVKH---------HGKQRKRM 358
            .:|| .::...:.:|:.:|...:|:||||:::.|:...:.|..:|.:.         :|:::|:
Yeast   306 ESAITTNRDDLENSQTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKK- 369

  Fly   359 QTVNARAKTTEKMSTTLGPKSFSIDRLLAIFYAI--------------LEEKVGLTCNL-----L 404
             .||.|         .|.|..|:|:||||||.||              |.|:..:..|:     |
Yeast   370 -EVNPR---------YLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIEVFQNL 424

  Fly   405 SQISTLVHLNLLSFVSGEQNI--MEGSARLQCTIGLEFVLQIGKVVGFNVRQYLCD 458
            |::.||    .|...:..:||  :....|.:..:..|.:.:|.:.|.||:..|..|
Yeast   425 SELHTL----KLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSD 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc5	NP_477132.1	CDC6	12..>159	CDD:224391	38/162 (23%)
		AAA_16	12..151	CDD:289934	37/153 (24%)
		ORC5_C	178..456	CDD:291304	72/325 (22%)
ORC5	NP_014138.1	AAA_16	11..146	CDD:404141	34/137 (25%)
		ORC5_C	189..474	CDD:405335	72/323 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344850
Domainoid	1	1.000	44	1.000	Domainoid score	I3147
eggNOG	1	0.900	-	-		E1_KOG2543
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I1699
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S4134
OMA	1	1.010	-	-		QHG52064
OrthoFinder	1	1.000	-	-		FOG0004930
OrthoInspector	1	1.000	-	-		oto99500
orthoMCL	1	0.900	-	-		OOG6_103513
Panther	1	1.100	-	-	LDO	PTHR12705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R874
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740