DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc5 and orc5

DIOPT Version :9

Sequence 1:	NP_477132.1	Gene:	Orc5 / 34794	FlyBaseID:	FBgn0015271	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001017013.1	Gene:	orc5 / 549767	XenbaseID:	XB-GENE-954698	Length:	448	Species:	Xenopus tropicalis

Alignment Length:	461	Identity:	167/461 - (36%)
Similarity:	259/461 - (56%)	Gaps:	49/461 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CREAAIETLGELIGDSSE-TYPSAIYLFGHSGTGKTALTRAFLKECGKRQNVRTAHLNAIECYTT 77
            |||:.:.||..:.|:... ::|| |:::||:|||||.:.:..|...    .:..|.:|.:||:|.
Frog    23 CRESQVSTLLSIFGERQHLSFPS-IFIYGHTGTGKTYILQTVLSTL----ELPCAFINCVECFTP 82

  Fly    78 KIMLEILLDSL-----APDQGDALK--VDNMLDFVEQLRRQAATRVEDQGFLIAVDNAERLRDMD 135
            :::.|.:|:.|     ||:...:.|  .|...|||....|..:.....:.|.|.:|.||.||:||
Frog    83 RLLFEQILNHLHHHHPAPENEFSSKERCDTFNDFVRLYNRGMSELSLQETFYIVLDKAELLREMD 147

  Fly   136 ANVLPVLLRLQELTNLNLCVILLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQRILGSDFQQVR 200
            ||:||..|||||||..|:.||.|:::.:|.|...||..|.:.|:...|:|.|.|:||.|:|
Frog   148 ANLLPGFLRLQELTESNVTVIFLTEIVWETFRPNTGCFEPLTLYFPDYSKVELQKILSSEF---- 208

  Fly   201 NQLLEQFAQDKKRLEICQEAVTEDFYNNYLNLFLSVFYKACRDVPELQLTARKCLSTYLEPVLDG 265
                             ....:.:||.:|:|:.|.|||..|||:.||:..|......:.|||:.|
Frog   209 -----------------PVKYSAEFYASYINILLGVFYTVCRDIKELRHLAALNFPKFCEPVIKG 256

  Fly   266 TVDATDISRLWRHIAGPLRSALTQIYMR------IEKPAEEVEDFTAIEDQSVRKLAQSLELPYY 324
            ....:|..:||::|...|:.|:..:|:|      .|:..:|..:.:.::..|..   ..:|||||
Frog   257 EAKESDSHKLWKNIEPHLKRAMQTVYLREISSSQWERIQQEDREASHLKGLSAH---AHVELPYY 318

  Fly   325 AKFLLIAAFLASHNAAKQDKRLFVKHHGKQRKRMQTVNARAKTTEKMSTTLGPKSFSIDRLLAIF 389
            :|||||||:|||.|.|:.|||.|:||||| .|:...:....||:..:   ||||.|.:||||||.
Frog   319 SKFLLIAAYLASFNPARTDKRFFLKHHGK-IKKTDFLKKHEKTSNHL---LGPKPFPLDRLLAIL 379

  Fly   390 YAILEEKVGLTCNLLSQISTLVHLNLLSFVSGEQNIMEGSARLQCTIGLEFVLQIGKVVGFNVRQ 454
            |:|::.:|..|.|:.||||:||.|.||:.| |..:.::| .:.:||:.|:|:..:.:.|.|::.:
Frog   380 YSIVDSRVAPTANIFSQISSLVTLQLLTLV-GHDDQLDG-PKYKCTVSLDFIRAVARTVNFDIVR 442

  Fly   455 YLCDFM 460
            ||.||:
Frog   443 YLYDFL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc5	NP_477132.1	CDC6	12..>159	CDD:224391	56/152 (37%)
		AAA_16	12..151	CDD:289934	53/144 (37%)
		ORC5_C	178..456	CDD:291304	101/283 (36%)
orc5	NP_001017013.1	AAA_16	23..168	CDD:289934	54/149 (36%)
		CDC6	24..>204	CDD:224391	66/184 (36%)
		ORC5_C	190..444	CDD:291304	101/283 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I4232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37636
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3113
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D438169at33208
OrthoFinder	1	1.000	-	-		FOG0004930
OrthoInspector	1	1.000	-	-		oto103498
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R874
SonicParanoid	1	1.000	-	-		X5263
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090