DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc5 and ORC5

DIOPT Version :9

Sequence 1:	NP_477132.1	Gene:	Orc5 / 34794	FlyBaseID:	FBgn0015271	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_002544.1	Gene:	ORC5 / 5001	HGNCID:	8491	Length:	435	Species:	Homo sapiens

Alignment Length:	470	Identity:	170/470 - (36%)
Similarity:	262/470 - (55%)	Gaps:	55/470 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LEPLFPCREAAIETLGELIGDSSE-TYPSAIYLFGHSGTGKTALTRAFLKECGKRQNVRTAH--L 69
            ||.:..|||:.:..|..|.|:... ::|| |:::||:.:|||.:|:..||      .:...|  :
Human     4 LENVVLCRESQVSILQSLFGERHHFSFPS-IFIYGHTASGKTYVTQTLLK------TLELPHVFV 61

  Fly    70 NAIECYTTKIMLEILLDSL----APDQGDALKV--DNMLDFVEQLRRQAAT--RVEDQGFLIAVD 126
            |.:||:|.:::||.:|:.|    :.:.|.:.::  :...||| :|.:|..|  .::||...|.:|
Human    62 NCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFV-RLFKQVTTAENLKDQTVYIVLD 125

  Fly   127 NAERLRDMDANVLPVLLRLQELTNLNLCVILLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQRI 191
            .||.||||:||:||..||||||.:.|:.|:.||::.:|||...||..|...|:...|:....|:|
Human   126 KAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKI 190

  Fly   192 LGSDFQQVRNQLLEQFAQDKKRLEICQEAVTEDFYNNYLNLFLSVFYKACRDVPELQLTARKCLS 256
            |..|.                     ....:.|||..|:|:.|.|||..|||:.||:..|.....
Human   191 LSHDH---------------------PPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFP 234

  Fly   257 TYLEPVLDGTVDATDISRLWRHIAGPLRSALTQIYMR------IEKPAEEVEDFTAIEDQSVRKL 315
            .|.|||:.|.....|..:|||:|...|:.|:..:|:|      .||..::..|...::..|..
Human   235 KYCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAH-- 297

  Fly   316 AQSLELPYYAKFLLIAAFLASHNAAKQDKRLFVKHHGKQRKRMQTVNARAKTTEKMSTTLGPKSF 380
             ..:|||||:||:||||:|||:|.|:.|||.|:|||||.:|    .|...|..:..:..||||.|
Human   298 -THVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKK----TNFLKKHEKTSNHLLGPKPF 357

  Fly   381 SIDRLLAIFYAILEEKVGLTCNLLSQISTLVHLNLLSFVSGEQNIMEGSARLQCTIGLEFVLQIG 445
            .:||||||.|:|::.:|..|.|:.|||::||.|.||:.| |..:.::| .:.:||:.|:|:..|.
Human   358 PLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLV-GHDDQLDG-PKYKCTVSLDFIRAIA 420

  Fly   446 KVVGFNVRQYLCDFM 460
            :.|.|::.:||.||:
Human   421 RTVNFDIIKYLYDFL 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc5	NP_477132.1	CDC6	12..>159	CDD:224391	55/157 (35%)
		AAA_16	12..151	CDD:289934	53/149 (36%)
		ORC5_C	178..456	CDD:291304	101/283 (36%)
ORC5	NP_002544.1	AAA_16	8..155	CDD:404141	54/154 (35%)
ORC5	NP_002544.1	ORC5_C	177..431	CDD:405335	101/283 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152687
Domainoid	1	1.000	169	1.000	Domainoid score	I3818
eggNOG	1	0.900	-	-		E1_KOG2543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37636
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3071
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52064
OrthoDB	1	1.010	-	-		D438169at33208
OrthoFinder	1	1.000	-	-		FOG0004930
OrthoInspector	1	1.000	-	-		oto89682
orthoMCL	1	0.900	-	-		OOG6_103513
Panther	1	1.100	-	-	LDO	PTHR12705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R874
SonicParanoid	1	1.000	-	-		X5263
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800