DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc5 and orc5

DIOPT Version :9

Sequence 1:	NP_477132.1	Gene:	Orc5 / 34794	FlyBaseID:	FBgn0015271	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_595372.1	Gene:	orc5 / 2541107	PomBaseID:	SPBC646.14c	Length:	455	Species:	Schizosaccharomyces pombe

Alignment Length:	497	Identity:	130/497 - (26%)
Similarity:	217/497 - (43%)	Gaps:	113/497 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CREAAIETLGELIGDSSETYPSAIYLFGHSGTGKTALTR-AFLKECGKRQNVRTAHLNAIECYTT 77
            |||..|:.|..|:.:.....|| |.|:|.:.|.||.|.| ||  :..|.:||   .:|..:|:|.
pombe    16 CREDQIKKLSCLLFNKDCRVPS-IVLYGVASTAKTFLLRTAF--DLSKEENV---WINLQDCFTV 74

  Fly    78 KIMLEILLDSLAPDQGDALKVD-NMLDFVEQLRRQAATRVEDQGFLIAVDNAERLRDMDANVLPV 141
            ......:|..:..|:..|||.. |:..|: .|..||.::.:...||: :|..:...:....:...
pombe    75 AHFWYRILIKVGVDKDIALKKGINISGFI-YLLEQAMSKRDYHTFLV-LDQIDDFAEASTILFSQ 137

  Fly   142 LLRLQELTNL-NLCVI-LLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQRILGSDFQQVRNQLL 204
            |.:|..:.|: ||.:| :|...|.:..    |...|..:...||.:||.
pombe   138 LAQLPIVANIPNLSIIFVLHSHPAQYL----GTLSIAVIFFPQYTQAEI---------------- 182

  Fly   205 EQFAQDKKRLEICQ-------------EAVTED-----FYNNYLNLFLSVFYKAC-RDVPELQLT 250
                     |||||             ::|.||     .:..|.:...|||...| .|....:..
pombe   183 ---------LEICQKTPPNLDFLDRSGDSVFEDEIELSVWMQYCSFLWSVFGVQCLNDYRSFRSV 238

  Fly   251 ARKCLSTYLEPVLDGTVDATDISRLWRHIAGPLRSALTQIYMRIEKPAEE--VEDFTA------I 307
            ..:....:::|:::|.:...|                   |.::.|.|:.  |.|.|.      |
pombe   239 LDRYWPKFIQPIVEGDIHPAD-------------------YAQLHKLAKNFLVSDATVTKRLHII 284

  Fly   308 EDQSVRKL--AQSLELPYYAKFLLIAAFLASHNAAKQDKRLF-----VKHHGKQRKRMQ------ 359
            ....::.|  ::|:.|...:|:||::|||||:|.::.|.:.|     .|..|::||::|
pombe   285 NPTEIKNLLDSKSINLSLVSKYLLVSAFLASYNPSRLDAQFFSFSKTSKRRGRKRKQIQDEGVLF 349

  Fly   360 -----TVNARAKTTEKMS-TTLGPKSFSIDRLLAIFYAILE--EKVGLTCNLLSQISTLVHLNLL 416
                 |..::.::..|:| .|||||.|.::||:||:|||..  ||| ||.::..||:||..|.::
pombe   350 SKIPRTAGSKGRSAVKISQLTLGPKPFEVERLIAIYYAISSPVEKV-LTADVFVQIATLASLKMI 413

  Fly   417 SFVSGEQNIMEG--SARLQCTIGLEFVLQIGKVVGFNVRQYL 456
              :|..:.::..  |.|....:..|:||:|...:.|.:..||
pombe   414 --LSASKGVLRSLDSPRYIVNVSREYVLKIADSLSFPLDSYL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc5	NP_477132.1	CDC6	12..>159	CDD:224391	43/148 (29%)
		AAA_16	12..151	CDD:289934	39/138 (28%)
		ORC5_C	178..456	CDD:291304	81/327 (25%)
orc5	NP_595372.1	AAA_16	14..147	CDD:289934	39/138 (28%)
		CDC6	17..>185	CDD:224391	51/204 (25%)
		ORC5_C	172..453	CDD:291304	81/327 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	1.000	Domainoid score	I2286
eggNOG	1	0.900	-	-		E1_KOG2543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37636
Inparanoid	1	1.050	106	1.000	Inparanoid score	I1608
OMA	1	1.010	-	-		QHG52064
OrthoFinder	1	1.000	-	-		FOG0004930
OrthoInspector	1	1.000	-	-		oto101115
orthoMCL	1	0.900	-	-		OOG6_103513
Panther	1	1.100	-	-	LDO	PTHR12705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R874
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860