DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arpc1 and arpc1b

DIOPT Version :9

Sequence 1:	NP_476596.1	Gene:	Arpc1 / 34793	FlyBaseID:	FBgn0001961	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001006824.1	Gene:	arpc1b / 448555	XenbaseID:	XB-GENE-490410	Length:	369	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	193/368 - (52%)
Similarity:	259/368 - (70%)	Gaps:	8/368 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LASITCHAWNKDRTQIALSPNNHEIHIYSREGSDWKLADVLNQHDLRVMGIDWAKNTNRIVSCAA 75
            |..|||||||||.||||..||:|::|||.::|..|.....|.:|:.:|.|||||.::||||:|..
Frog     8 LEPITCHAWNKDATQIAFCPNSHDVHIYKKDGDKWTKIHELKEHNGQVTGIDWAPDSNRIVTCGT 72

  Fly    76 DRNAYVWTQGDDGKWKPALVLLRINRAATCVKWSPAENKFAVGSGARLISVCYFESENDWWVSKH 140
            ||||||||..:: .|||.||:|||||||.||||||.|||||||||:||||:||||.||||||.||
Frog    73 DRNAYVWTLRNN-VWKPTLVILRINRAARCVKWSPKENKFAVGSGSRLISICYFEQENDWWVCKH 136

  Fly   141 IKKPIRSTVTSLDWHPNNVLLLAGSTDYKVRVFSAFIKDIEEPPTPTPWGNRKPLGQLMAEFRNS 205
            |||||||||.|||||||||||.|||:|:|.|:|||:||::||.|.|||||::.|.|:||.|
Frog   137 IKKPIRSTVLSLDWHPNNVLLAAGSSDFKSRIFSAYIKEVEERPAPTPWGSKMPFGELMFE---- 197

  Fly   206 QTSGGGWINSVSFSSDGNKVCWVGHDSCVSIADATNGNTVIRCRTGYLPFLSCEWVSPTSVVVAG 270
            .:|..||::||.||..|:::.||.|||.:.||||.....|....|..||.|...:::..|:|.||
Frog   198 SSSSCGWVHSVCFSHSGDRMAWVSHDSTICIADAPKKMRVTTSITDTLPLLCLTFITENSLVAAG 262

  Fly   271 YSCVPLLYS-LTADGKLVLSGKLDKSQKKESSGITAMRIFQSMDRNMRTENTDTVVDSIHQNAIT 334
            :.|.|:||| :.|.|.|...||||..::....|:||...||::|:...::..:..:||:|:|:|:
Frog   263 HDCYPVLYSYVEAQGTLSFGGKLDIPKQSSQRGMTARERFQNLDKKASSDTNNVTLDSLHKNSIS 327

  Fly   335 SVRLYAGDKASATKVSTSGVDGQLVIWNVEQGGINGGMRNLQI 377
            .:.:.:|.||..:|..|:|:||.:.||:|:.  :...|::|:|
Frog   328 QISVLSGGKAKCSKFCTTGLDGGMCIWDVKI--LESAMKDLKI 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arpc1	NP_476596.1	WD40	<3..236	CDD:295369	143/224 (64%)
		WD40	<3..181	CDD:225201	117/169 (69%)
		WD40 repeat	14..53	CDD:293791	22/38 (58%)
		WD40 repeat	59..97	CDD:293791	23/37 (62%)
		WD40 repeat	103..142	CDD:293791	32/38 (84%)
		WD40	146..>366	CDD:295369	99/220 (45%)
		WD40 repeat	150..203	CDD:293791	35/52 (67%)
		WD40 repeat	213..247	CDD:293791	15/33 (45%)
arpc1b	NP_001006824.1	WD40 repeat	11..50	CDD:293791	22/38 (58%)
		WD40	45..>264	CDD:392136	134/223 (60%)
		WD40 repeat	56..93	CDD:293791	23/37 (62%)
		WD40 repeat	99..138	CDD:293791	32/38 (84%)
		WD40 repeat	146..199	CDD:293791	35/56 (63%)
		WD40 repeat	205..241	CDD:293791	15/35 (43%)
		WD40 repeat	247..319	CDD:293791	23/71 (32%)
		WD40 repeat	326..354	CDD:293791	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3367
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1613
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D317177at33208
OrthoFinder	1	1.000	-	-		FOG0001692
OrthoInspector	1	1.000	-	-		otm48305
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R87
SonicParanoid	1	1.000	-	-		X1085
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090