DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arpc1 and ARPC1B

DIOPT Version :9

Sequence 1:	NP_476596.1	Gene:	Arpc1 / 34793	FlyBaseID:	FBgn0001961	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_005711.1	Gene:	ARPC1B / 10095	HGNCID:	704	Length:	372	Species:	Homo sapiens

Alignment Length:	369	Identity:	186/369 - (50%)
Similarity:	257/369 - (69%)	Gaps:	13/369 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ITCHAWNKDRTQIALSPNNHEIHIYSREGSDWKLADVLNQHDLRVMGIDWAKNTNRIVSCAADRN 78
            |:||||||||||||:.|||||:|||.:.|:.|.....|.:|:.:|.|||||..:||||:|..|||
Human    11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75

  Fly    79 AYVWTQGDDGK-WKPALVLLRINRAATCVKWSPAENKFAVGSGARLISVCYFESENDWWVSKHIK 142
            |||||.  .|: |||.||:|||||||.||:|:|.|||||||||:|:||:||||.||||||.||||
Human    76 AYVWTL--KGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIK 138

  Fly   143 KPIRSTVTSLDWHPNNVLLLAGSTDYKVRVFSAFIKDIEEPPTPTPWGNRKPLGQLMAEFRNSQT 207
            |||||||.|||||||||||.|||.|:|.|:|||:||::||.|.|||||::.|.|:||.|    .:
Human   139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE----SS 199

  Fly   208 SGGGWINSVSFSSDGNKVCWVGHDSCVSIADATNGNTVIRCRTGYLPFLSCEWVSPTSVVVAGYS 272
            |..||::.|.||:.|::|.||.|||.|.:|||.....|....:..||.|:..:::..|:|.||:.
Human   200 SSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHD 264

  Fly   273 CVPLLYSL-TADGKLVLSGKLDKSQKKESSGITAMRIFQSMDRNMRTENTDTV---VDSIHQNAI 333
            |.|:|::. .|.|.|...|:||..::....|:||...||::|:...:|.....   :||:|:|::
Human   265 CFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSV 329

  Fly   334 TSVRLYAGDKASATKVSTSGVDGQLVIWNVEQGGINGGMRNLQI 377
            :.:.:.:|.||..::..|:|:||.:.||:|:  .:...:::|:|
Human   330 SQISVLSGGKAKCSQFCTTGMDGGMSIWDVK--SLESALKDLKI 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arpc1	NP_476596.1	WD40	<3..236	CDD:295369	143/222 (64%)
		WD40	<3..181	CDD:225201	116/167 (69%)
		WD40 repeat	14..53	CDD:293791	24/38 (63%)
		WD40 repeat	59..97	CDD:293791	24/38 (63%)
		WD40 repeat	103..142	CDD:293791	29/38 (76%)
		WD40	146..>366	CDD:295369	94/223 (42%)
		WD40 repeat	150..203	CDD:293791	35/52 (67%)
		WD40 repeat	213..247	CDD:293791	15/33 (45%)
ARPC1B	NP_005711.1	WD 1	6..45		23/33 (70%)
		WD40	<9..79	CDD:421866	41/67 (61%)
		WD40 repeat	11..50	CDD:293791	24/38 (63%)
		WD40	45..264	CDD:421866	131/224 (58%)
		WD 2	50..89		23/40 (58%)
		WD40 repeat	56..93	CDD:293791	24/38 (63%)
		WD 3	94..135		32/40 (80%)
		WD40 repeat	99..138	CDD:293791	29/38 (76%)
		WD 4	140..179		29/38 (76%)
		WD40 repeat	146..199	CDD:293791	35/56 (63%)
		WD40 repeat	205..241	CDD:293791	15/35 (43%)
		WD 5	242..280		12/37 (32%)
		WD40 repeat	247..286	CDD:293791	12/38 (32%)
		WD 6	324..367		12/44 (27%)
		WD40 repeat	329..357	CDD:293791	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159807
Domainoid	1	1.000	175	1.000	Domainoid score	I3652
eggNOG	1	0.900	-	-		E1_KOG1523
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1679
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54320
OrthoDB	1	1.010	-	-		D317177at33208
OrthoFinder	1	1.000	-	-		FOG0001692
OrthoInspector	1	1.000	-	-		otm41100
orthoMCL	1	0.900	-	-		OOG6_101628
Panther	1	1.100	-	-	LDO	PTHR10709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R87
SonicParanoid	1	1.000	-	-		X1085
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840