Protein Alignment Arpc1 and ARPC1B

DIOPT Version :10

• Sequence 1: NP_476596.1
• Gene: Arpc1 / 34793
• FlyBaseID: FBgn0001961
• Length: 377
• Species: Drosophila melanogaster
• Sequence 2: NP_005711.1
• Gene: ARPC1B / 10095
• HGNCID: 704
• Length: 372
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 186/369 - (50%)
• Similarity: 257/369 - (69%)
• Gaps: 13/369 - (3%)

  Fly    14 ITCHAWNKDRTQIALSPNNHEIHIYSREGSDWKLADVLNQHDLRVMGIDWAKNTNRIVSCAADRN 78
            |:||||||||||||:.|||||:|||.:.|:.|.....|.:|:.:|.|||||..:||||:|..|||
Human    11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75

  Fly    79 AYVWTQGDDGK-WKPALVLLRINRAATCVKWSPAENKFAVGSGARLISVCYFESENDWWVSKHIK 142
            |||||.  .|: |||.||:|||||||.||:|:|.|||||||||:|:||:||||.||||||.||||
Human    76 AYVWTL--KGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIK 138

  Fly   143 KPIRSTVTSLDWHPNNVLLLAGSTDYKVRVFSAFIKDIEEPPTPTPWGNRKPLGQLMAEFRNSQT 207
            |||||||.|||||||||||.|||.|:|.|:|||:||::||.|.|||||::.|.|:||.|    .:
Human   139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE----SS 199

  Fly   208 SGGGWINSVSFSSDGNKVCWVGHDSCVSIADATNGNTVIRCRTGYLPFLSCEWVSPTSVVVAGYS 272
            |..||::.|.||:.|::|.||.|||.|.:|||.....|....:..||.|:..:::..|:|.||:.
Human   200 SSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHD 264

  Fly   273 CVPLLYSL-TADGKLVLSGKLDKSQKKESSGITAMRIFQSMDRNMRTENTDTV---VDSIHQNAI 333
            |.|:|::. .|.|.|...|:||..::....|:||...||::|:...:|.....   :||:|:|::
Human   265 CFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSV 329

  Fly   334 TSVRLYAGDKASATKVSTSGVDGQLVIWNVEQGGINGGMRNLQI 377
            :.:.:.:|.||..::..|:|:||.:.||:|:  .:...:::|:|
Human   330 SQISVLSGGKAKCSQFCTTGMDGGMSIWDVK--SLESALKDLKI 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arpc1	NP_476596.1	WD40	<3..236	CDD:475233	143/222 (64%)
		WD40 repeat	14..53	CDD:293791	24/38 (63%)
		WD40 repeat	59..97	CDD:293791	24/38 (63%)
		WD40 repeat	103..142	CDD:293791	29/38 (76%)
		WD40	146..>366	CDD:475233	94/223 (42%)
		WD40 repeat	150..203	CDD:293791	35/52 (67%)
		WD40 repeat	213..247	CDD:293791	15/33 (45%)
ARPC1B	NP_005711.1	WD 1	6..45		23/33 (70%)
		WD40 repeat	11..50	CDD:293791	24/38 (63%)
		WD40	<15..264	CDD:441893	151/254 (59%)
		WD 2	50..89		23/40 (58%)
		WD40 repeat	56..93	CDD:293791	24/38 (63%)
		WD 3	94..135		32/40 (80%)
		WD40 repeat	99..138	CDD:293791	29/38 (76%)
		WD 4	140..179		29/38 (76%)
		WD40 repeat	146..199	CDD:293791	35/56 (63%)
		WD40 repeat	205..241	CDD:293791	15/35 (43%)
		WD 5	242..280		12/37 (32%)
		WD40 repeat	247..286	CDD:293791	12/38 (32%)
		WD 6	324..367		12/44 (27%)
		WD40 repeat	329..357	CDD:293791	7/27 (26%)