DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tam and MIP1

DIOPT Version :9

Sequence 1:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	NP_014975.2	Gene:	MIP1 / 854508	SGDID:	S000005857	Length:	1254	Species:	Saccharomyces cerevisiae

Alignment Length:	1147	Identity:	374/1147 - (32%)
Similarity:	564/1147 - (49%)	Gaps:	253/1147 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NLVKVQMISRNLHAQLFPQ-APRSISEQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRG 117
            |.|.:|.:..:|..|:|.. ..:...||.....::.|..|:.||:..:.:.....:...||.|:|
Yeast    42 NPVGIQYLGESLQRQVFGSCGGKDEVEQSDKLMELSKKSLKDHGLWGKKTLITDPISFPLPPLQG 106

  Fly   118 ANIEEHFHNIAKEQVQPYEELLLPLVQCE----QLPKRPKRWAFHTGWTAYDPEDGTATPVD--H 176
            .:::|||..|.:...:||:..      ||    ::..||..|....||..|.|  |.| ||:  :
Yeast   107 RSLDEHFQKIGRFNSEPYKSF------CEDKFTEMVARPAEWLRKPGWVKYVP--GMA-PVEVAY 162

  Fly   177 PLEKGLVFDVEVCVSEGQAPVLATAVSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTT 241
            |.|:.:|||||...:....|.||||:|:..||.|.|              |.....|...
Yeast   163 PDEELVVFDVETLYNVSDYPTLATALSSTAWYLWCS--------------PFICGGDDPA----- 208

  Fly   242 DELIPLGTTG-PGLVVGHNVSYDRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAM-LKSK 304
             .||||.|.. ..:::||||:|||||:.|:|...|:...|:||.|||:...|:.|.||.| :|:.
Yeast   209 -ALIPLNTLNKEQVIIGHNVAYDRARVLEEYNFRDSKAFFLDTQSLHIASFGLCSRQRPMFMKNN 272

  Fly   305 KEPAAE--------------DLGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQS 355
            |:..||              |..||..|:||||.:|.:.:|..| |.|..|:.|.......:.::
Yeast   273 KKKEAEVESEVHPEISIEDYDDPWLNVSALNSLKDVAKFHCKID-LDKTDRDFFASTDKSTIIEN 336

  Fly   356 FQSLTNYCASDVEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSN-WERYIREAQLTY 419
            ||.|.||||:||.||.::...::|::.::.|||.|.||:..:....||...| |..|:..::..|
Yeast   337 FQKLVNYCATDVTATSQVFDEIFPVFLKKCPHPVSFAGLKSLSKCILPTKLNDWNDYLNSSESLY 401

  Fly   420 EDLSIEAKYHLGRRAEEACSLLLD--DQYRQNLWLWDEDWSVQELKLKQPPKRKPLPTVELKDSG 482
            :...::.:..:.:..::.. ||.|  |.|.::.||...||:.:.|:|.:..
Yeast   402 QQSKVQIESKIVQIIKDIV-LLKDKPDFYLKDPWLSQLDWTTKPLRLTKKG-------------- 451

  Fly   483 NTPEERRLQAKFQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASE 547
                                 :||:...|||:|.|||:|.   |:|       |..||      :
Yeast   452 ---------------------VPAKCQKLPGFPEWYRQLF---PSK-------DTVEP------K 479

  Fly   548 ISTGMQIAPKLLSLCWEGYPLHYEREQGWGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSAS 612
            |:...:|.|.|..|.||..|:.:.:|.||.|.||..
Yeast   480 ITIKSRIIPILFKLSWENSPVIWSKESGWCFNVPHE----------------------------- 515

  Fly   613 KAESDMAFDMLPGQVEQHLGKREHY---KKLSQKQQRLETQYQGSGVWCNKVLDDCCFFLKLPHK 674
                         |||.:  |.::|   ..:||:::.:.|  ...|:.|..||      .|:||.
Yeast   516 -------------QVETY--KAKNYVLADSVSQEEEEIRT--HNLGLQCTGVL------FKVPHP 557

  Fly   675 NGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQ 739
            |||:|...|.|:|.:.:.|.:.||.|   ..:.|.:.:.|....|||.:.|:||..|.||  .|.
Yeast   558 NGPTFNCTNLLTKSYNHFFEKGVLKS---ESELAHQALQINSSGSYWMSARERIQSQFVV--PSC 617

  Fly   740 QLPNEF---------TGEKCQPIAYGAICPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSM 795
            :.||||         ..||...:|  .|.|::|..||:||||:|..|:||||::.:|:||||::.
Yeast   618 KFPNEFQSLSAKSSLNNEKTNDLA--IIIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQ 680

  Fly   796 VQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGSKSNGSDMHSITAKAVGIS 860
            |:|||||..|||||||:||||||::||: ....||.|.:|||.|.|:|:.|:|:|:.||:.:|.|
Yeast   681 VKAPPGYCFVGADVDSEELWIASLVGDS-IFNVHGGTAIGWMCLEGTKNEGTDLHTKTAQILGCS 744

  Fly   861 RDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGK-RVYRLREEFHDELE 924
            |:.||:.||.||||||..||..||::|||:.:..|.|..|.|::..|||| :..:|.::|
Yeast   745 RNEAKIFNYGRIYGAGAKFASQLLKRFNPSLTDEETKKIANKLYENTKGKTKRSKLFKKF----- 804

  Fly   925 DRAYSSYEASRLAIQRNRTLAEVFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLG-----GRLS 984
                                        |.||:||.:||:||.||....|:||.||     ..:.
Yeast   805 ----------------------------WYGGSESILFNKLESIAEQETPKTPVLGCGITYSLMK 841

  Fly   985 RALEADTGPEQEQRFLPTRINWVVQSGAVDFLHLMLVSMRWLMGSH---VRFCLSFHDELRYLVK 1046
            :.|.|::       |||:||||.:||..||:|||:..||.:::..:   .|.|:|.|||:|:||.
Yeast   842 KNLRANS-------FLPSRINWAIQSSGVDYLHLLCCSMEYIIKKYNLEARLCISIHDEIRFLVS 899

  Fly  1047 EELSPKAALAMHITNLMTRSFCVSRIGLQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSN----P 1107
            |:...:||:|:.|:|:.||:....::|:.:||.:.||||.|::|:|:|||..|||.||||    |
Yeast   900 EKDKYRAAMALQISNIWTRAMFCQQMGINELPQNCAFFSQVDIDSVIRKEVNMDCITPSNKTAIP 964

  Fly  1108 HGLRIGYGIQPGQSLSVAEAIEKAGG----------NDVSQW 1139
            |          |::|.:.:.::|:..          :.|||:
Yeast   965 H----------GEALDINQLLDKSNSKLGKPNLDIDSKVSQY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	6/42 (14%)
		TRH	<420..539	CDD:283171	24/120 (20%)
		DNA_pol_gammaA	705..1107	CDD:176478	175/423 (41%)
MIP1	NP_014975.2	DNApol_Exo	95..362	CDD:407968	101/296 (34%)
MIP1	NP_014975.2	DNA_pol_gammaA	581..960	CDD:176478	176/426 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345476
Domainoid	1	1.000	292	1.000	Domainoid score	I231
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2016
Inparanoid	1	1.050	535	1.000	Inparanoid score	I180
Isobase	1	0.950	-	0	Normalized mean entropy	S2606
OMA	1	1.010	-	-		QHG52013
OrthoFinder	1	1.000	-	-		FOG0004939
OrthoInspector	1	1.000	-	-		oto98969
orthoMCL	1	0.900	-	-		OOG6_104329
Panther	1	1.100	-	-	LDO	PTHR10267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R347
SonicParanoid	1	1.000	-	-		X3481
TreeFam	0	0.000	Not matched by this tool.
	14	13.780