DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tam and DDX60

DIOPT Version :9

Sequence 1:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	NP_060101.3	Gene:	DDX60 / 55601	HGNCID:	25942	Length:	1712	Species:	Homo sapiens

Alignment Length:	936	Identity:	170/936 - (18%)
Similarity:	291/936 - (31%)	Gaps:	385/936 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ASKVSREHYASSSVKIFRRVKPPQKVNKPKKPEN---VENGPTEYAENLVKVQMISRNLHAQLFP 71
            |.::..|::...:.|:..:....:|..:..|.|.   ::||      |:.:.:|:.:||.    |
Human  1047 AQELCPENFIHFNNKLVIKKMDARKYEESLKAELTSWIKNG------NVEQARMVLQNLS----P 1101

  Fly    72 QAPRSISEQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPYE 136
            :|..| .|..:....:..::||:              ..|||||        |.......|:...
Human  1102 EADLS-PENMITMFPLLVEKLRK--------------MEKLPAL--------FFLFKLGAVENAA 1143

  Fly   137 ELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATA 201
            |.:...::.:|..|||.:                                    ::.:|.|:|
Human  1144 ESVSTFLKKKQETKRPPK------------------------------------ADKEAHVMA-- 1170

  Fly   202 VSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYD--- 263
                       :||.|.:.|:||.:.:| :...::.......||            |...:|
Human  1171 -----------NKLRKVKKSIEKQKIID-EKSQKKTRNVDQSLI------------HEAEHDNLV 1211

  Fly   264 RARLKEQYLTED---TGTRFVDTMSLHMCVSGVTSYQRAMLKSKKEPAAEDLGWLEQSSL----- 320
            :...|...:.:|   ...:.|||.:|          |:...:.|.|...|:|..|.:..:
Human  1212 KCLEKNLEIPQDCTYADQKAVDTETL----------QKVFGRVKFERKGEELKALAERGIGYHHS 1266

  Fly   321 ------NSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRILRVLYP 379
                  ..|||:                :|.:|.|..|     :.|...|         |.|..|
Human  1267 AMSFKEKQLVEI----------------LFRKGYLRVV-----TATGTLA---------LGVNMP 1301

  Fly   380 LYAERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDD 444
            ..:..|          ...|.||..            |.|..:|..|    |||.::    |:.|
Human  1302 CKSVVF----------AQNSVYLDA------------LNYRQMSGRA----GRRGQD----LMGD 1336

  Fly   445 QYRQNLWLWDEDWSV--QELKLKQPPKRKPLP---TVELK-----DSGNTPEERRLQAKFQHLYD 499
            .|     .:|..:..  :.:|...|..|...|   |:.|:     ..|:.||:.:  ||...:.
Human  1337 VY-----FFDIPFPKIGKLIKSNVPELRGHFPLSITLVLRLMLLASKGDDPEDAK--AKVLSVL- 1393

  Fly   500 QQALLPARRP----LLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLS 560
            :.:||..::|    :|..|.|:                                 .:|...|...
Human  1394 KHSLLSFKQPRVMDMLKLYFLF---------------------------------SLQFLVKEGY 1425

  Fly   561 LCWEGYP---------LHYEREQGW---GFLV---------PFRSDSEGVDRLPMEQL---LAHC 601
            |..||.|         |||......   .|||         |.|..|:...:..||:|   |||.
Human  1426 LDQEGNPMGFAGLVSHLHYHEPSNLVFVSFLVNGLFHDLCQPTRKGSKHFSQDVMEKLVLVLAHL 1490

  Fly   602 ------PVPEFARLSASKAESDMAFDMLPGQVEQHLGKREHYKKLSQKQQRLETQYQGSGVWCNK 660
                  | |:|........:|.:..|.||......|   :.|..                    |
Human  1491 FGRRYFP-PKFQDAHFEFYQSKVFLDDLPEDFSDAL---DEYNM--------------------K 1531

  Fly   661 VLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNR 725
            :::|...||::                  ::|.|:
Human  1532 IMEDFTTFLRI------------------VSKLAD------------------------------ 1548

  Fly   726 DRIMGQMVVWLDSQQLP---NEFTGEKCQPIAYGAICPQVVACGTLTRRAMEPTWMTASNSRPDR 787
               |.|      ..|||   .:|||::|:.   ..:...:::|.. .|.|:.|....:.|...|.
Human  1549 ---MNQ------EYQLPLSKIKFTGKECED---SQLVSHLMSCKE-GRVAISPFVCLSGNFDDDL 1600

  Fly   788 LGSELRSMV----------QAPPGYRLVGADVDSQELWIASVLGDAYACG--EHGATPLGWMTLS 840
            |..|..:.|          |||.   |:....|::...::.   :|||..  :||:. :|  .:.
Human  1601 LRLETPNHVTLGTIGVNRSQAPV---LLSQKFDNRGRKMSL---NAYALDFYKHGSL-IG--LVQ 1656

  Fly   841 GSKSNGSDMH------SITAKAVGIS 860
            .::.|..|.:      ::|.|::.:|
Human  1657 DNRMNEGDAYYLLKDFALTIKSISVS 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	10/41 (24%)
		TRH	<420..539	CDD:283171	26/132 (20%)
		DNA_pol_gammaA	705..1107	CDD:176478	34/177 (19%)
DDX60	NP_060101.3	Dob10	762..>1373	CDD:333050	89/495 (18%)
DDX60	NP_060101.3	DEVH box	889..892
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900