DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tam and POLG

DIOPT Version :9

Sequence 1:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	NP_001119603.1	Gene:	POLG / 5428	HGNCID:	9179	Length:	1239	Species:	Homo sapiens

Alignment Length:	1228	Identity:	539/1228 - (43%)
Similarity:	716/1228 - (58%)	Gaps:	174/1228 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLFPQAPRSISEQQVASAKVYKDELRRHGV 97
            |:..:|::|:.:.:...:...|.:.:||:||.||.|:|.|......|   |:.:...:.|::||:
Human    51 QQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGE---AAVRRSVEHLQKHGL 112

  Fly    98 DIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPYEELLLPLVQCEQLPKRPKRWAFHTGWT 162
            ..:.:.|:.||:|:||.|.|.|:::||..:|::|..||.|....|:|. |||.:|..||:..|||
Human   113 WGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQA-QLPPKPPAWAWAEGWT 176

  Fly   163 AYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATAVSTKRWYSWVSSKLTKHRLS-VEKLE 226
            .|.|| |.|.||..|.|:.||||||||::||..|.||.|:|...||||.|.:|.:.|.| ..:|.
Human   177 RYGPE-GEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLS 240

  Fly   227 PLDVDTDSERPHYTTDELIPL----GTTGP-------GLVVGHNVSYDRARLKEQYLTEDTGTRF 280
            |.|              ||||    |.:.|       .||||||||:|||.::||||.:.:..||
Human   241 PAD--------------LIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRF 291

  Fly   281 VDTMSLHMCVSGVTSYQRAM----------------------LKSKKEPAAEDLGWLEQSSLNSL 323
            :||||:||.:||::|:||::                      .|:::.||.....||:.||:|||
Human   292 LDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSL 356

  Fly   324 VEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRILRVLYPLYAERFPHP 388
            .||||||.||..|.||||.:||:||::.:|::||.|..|||.||.|||.:.:...||:.||.|||
Human   357 AEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHP 421

  Fly   389 ASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDDQYRQNLWLW 453
            .:||||||||.:|||||.|||||:.|||.|||:|..|.|..|...|.:||.||..::|:::.|||
Human   422 VTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLW 486

  Fly   454 DEDWSVQELKLKQPPKRKPLPT----------------VELKDSGNTPEERRLQ------AKFQH 496
            |.:|.:||.|.|:..|.|..|.                ::.:|.|...||...|      |..|.
Human   487 DLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQK 551

  Fly   497 LYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLSL 561
            |.....|||.|...|||:|.||||||.:.           |:..|:||.|.:|..|::.|||::|
Human   552 LKGTTELLPKRPQHLPGHPGWYRKLCPRL-----------DDPAWTPGPSLLSLQMRVTPKLMAL 605

  Fly   562 CWEGYPLHYEREQGWGFLVPFRSDSEGVDRLP----MEQLLAHCP-------------------- 602
            .|:|:||||....|||:|||.|.|:  :.:||    :|.....||
Human   606 TWDGFPLHYSERHGWGYLVPGRRDN--LAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQL 668

  Fly   603 VPEFARLSASKAESDMA--------FDMLPGQVEQHLGKREHYK--------KLSQKQQRLETQ- 650
            :|:.|.|:.....:|.:        .|.|..:.|   .|.|:.:        .|:.:....:||
Human   669 MPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAE---AKMENLRAAVPGQPLALTARGGPKDTQP 730

  Fly   651 --YQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVID 713
              :.|:|.: |.|....|:|.|||||:|.|..||:|.:||||.|..:..|.:| |...:..|.::
Human   731 SYHHGNGPY-NDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAG-PGGASGPRALE 793

  Fly   714 IARMMSYWRNNRDRIMGQMVVWLDSQQLPN------EFTGEKCQPIAYGAICPQVVACGTLTRRA 772
            |.:|:|:|||...||..||||||....||.      ::..|.    .||||.||||..||:||||
Human   794 INKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEG----LYGAILPQVVTAGTITRRA 854

  Fly   773 MEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWM 837
            :||||:||||:||||:||||::||||||||.||||||||||||||:|||||:..|.||.|..|||
Human   855 VEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWM 919

  Fly   838 TLSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMK 902
            ||.|.||.|:|:||.||..|||||:|||:.||.|||||||.|||.||.|||...:..||..||.:
Human   920 TLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQ 984

  Fly   903 MFSITKGKRVYRLREE---FHDELE---DRAYSSYEASRLAIQRNRTLA------------EVFH 949
            |::.|||.|.|||.:|   ...||.   ||.    |...:::|..|.:.            ||..
Human   985 MYAATKGLRWYRLSDEGEWLVRELNLPVDRT----EGGWISLQDLRKVQRETARKSQWKKWEVVA 1045

  Fly   950 RPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSGAVD 1014
            ...|:|||||.|||:||.|||...||||.||..:|||||.....|:   |:.:|:||||||.|||
Human  1046 ERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEE---FMTSRVNWVVQSSAVD 1107

  Fly  1015 FLHLMLVSMRWLMGSHV---RFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVSRIGLQD 1076
            :||||||:|:||.....   |||:|.|||:||||:||...:||||:.||||:||.....::||.|
Human  1108 YLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLND 1172

  Fly  1077 LPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEKAGGN 1134
            ||.||||||:|::|..||||.||||||||||.|:...|||..|::|.:.:.||...|:
Human  1173 LPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGS 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	24/41 (59%)
		TRH	<420..539	CDD:283171	46/140 (33%)
		DNA_pol_gammaA	705..1107	CDD:176478	234/428 (55%)
POLG	NP_001119603.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		3/16 (19%)
		DnaQ_like_exo	<265..>297	CDD:299142	20/31 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..340		1/21 (5%)
		DNA_pol_A	431..>473	CDD:295402	24/41 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531		2/24 (8%)
		DNA_pol_gammaA	785..1203	CDD:176478	234/428 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156634
Domainoid	1	1.000	412	1.000	Domainoid score	I677
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2016
Inparanoid	1	1.050	920	1.000	Inparanoid score	I356
Isobase	1	0.950	-	0	Normalized mean entropy	S2606
OMA	1	1.010	-	-		QHG52013
OrthoDB	1	1.010	-	-		D192641at33208
OrthoFinder	1	1.000	-	-		FOG0004939
OrthoInspector	1	1.000	-	-		oto88385
orthoMCL	1	0.900	-	-		OOG6_104329
Panther	1	1.100	-	-	LDO	PTHR10267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R347
SonicParanoid	1	1.000	-	-		X3481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790