DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tam and Helq

DIOPT Version :9

Sequence 1:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	NP_001014156.2	Gene:	Helq / 360912	RGDID:	1560216	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	173/934 - (18%)
Similarity:	303/934 - (32%)	Gaps:	328/934 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 LKEQYL-TEDTGTRFVDTMSLHMCVSGV------------TSYQRAMLKSK------KEP----- 307
            |:::|: ..|.|:|..|:.:..:|..|:            .|..|..:|.:      .||
  Rat    87 LEQKYIQLPDCGSRGTDSGTKDLCSEGLGNSLSVPAVDFTDSETREYIKKQGDLDVPVEPEVGGD 151

  Fly   308 ------------------AAEDLGWLEQSS-----LNSLVEVHRLYCGGDTLSKEPRNIF--VEG 347
                              :::|||  :||:     .:|..|:|..:    ....:|::.|  |.|
  Rat   152 LSFDMPSSQILYFESMQNSSKDLG--DQSTKGRDGKSSNEELHHSH----REQPQPKSDFSDVGG 210

  Fly   348 TLEQVRQSFQSLTNYCASDVEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNWERYI 412
            :.|..|:  :|:.:...|.:....|.....:|.                            .:.:
  Rat   211 SSEASRR--RSIKDCLKSAMTGNARAQTPAFPR----------------------------SKQL 245

  Fly   413 REAQLTYEDLSIEAKYHLGRRAEEACS----------LLLDDQYRQ-----NLWLWDEDWSVQEL 462
            ||..|: |::|:      .|:|.|:.|          ..:.|.|.|     .|:    ||....|
  Rat   246 RETLLS-EEISV------ARKAIESPSDDLGPFYSLPSKVRDLYAQLKGIKRLY----DWQHTCL 299

  Fly   463 KLKQPPKRKPLPTVELKDSGNTPEERRLQAKFQHLYDQQALLPARRP---LLPGYPLWYRKLC-- 522
            .|....:||.| ...|..||.    :.|.|:...|   |.||..::.   :||...:...|:.
  Rat   300 TLSSVQERKNL-IYSLPTSGG----KTLVAEILML---QELLCRQKDVLLILPYVAIVQEKISSL 356

  Fly   523 -------------------RKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLSLCWEGYPL 568
                               |.||.||        .|..|...:.|..|..:...|:
  Rat   357 SSFGIELGFFVEEYAGSKGRFPPIKR--------REKKSLYIATIEKGHSLVNALI--------- 404

  Fly   569 HYEREQG----WGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSASKAESDMAFDMLPGQVEQ 629
                |.|    .|.:|        ||.|.|        :.|.:|               ...:|.
  Rat   405 ----ETGRMGTLGLVV--------VDELHM--------IGEGSR---------------GATLEM 434

  Fly   630 HLGKREHYKKLSQKQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLS-KDFLNKF 693
            .|.|..:..|        .||..|.....|.| :|...|||..:... .||   |:. |:|
  Rat   435 TLAKVLYTSK--------TTQIIGMSATLNNV-EDLQAFLKAEYYTS-QFR---PVELKEF---- 482

  Fly   694 AENVLSSGDPSCQAAARVID---IARMMSY-WRNNRDRIMGQMVVWLDSQQLPNEFTGEKCQPIA 754
                |...|...:..:|.:|   .:|:::| :.:...::....:|.|.::.:||
  Rat   483 ----LKVNDTIYEVDSRAVDGMTFSRLLNYKYSDALKKVDPDRLVALVTEVIPN----------- 532

  Fly   755 YGAI--CPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPG---------------Y 802
            |..:  ||....|..:.....:.......|.|.:..|..::|:.....|               |
  Rat   533 YSCLVFCPSKKNCENVAEMLCKFLSRDYLNHREEEKGELIKSLRNVGHGKVCPVLKRTIPFGVAY 597

  Fly   803 RLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGSKSNGSDM--HSITAKAVGISRDHAK 865
            ...|...|.::|     |.:||:.|     .|...|.:.:.:.|.::  ..:..:|..::....|
  Rat   598 HHSGLTSDERKL-----LEEAYSTG-----VLCLFTCTSTLAAGVNLPARRVILRAPYVANTFLK 652

  Fly   866 VINYARIYG-AGQLFAET-----LLRQFNPTFSASEAKAKAMKMFSITKGKRVYRLREEFHDELE 924
            ...|.::.| ||:...:|     ||.|          :....::..:..|.     .|:.|..|.
  Rat   653 RNQYKQMIGRAGRAGIDTAGESILLLQ----------EKDKQQVLGLINGP-----LEDCHSHLV 702

  Fly   925 D---RAYSSYEASRLAIQRNRTLAEVFHRPNWQ--GGTESAMFNR--LEEIATGSQPRTPFLGGR 982
            :   :...|...|.:.::...:|.:::...|..  |..:..:...  |.|:..|:.......|
  Rat   703 EEFTKGIQSLFLSLIGLKIAESLGDIYQFMNGTLFGVQQKTLLREKSLWEVTVGALEHLTEKG-- 765

  Fly   983 LSRALEADT-GPEQEQR--FLPTRINWVVQSGAVDFLHLMLVSMRWLMGSHVRFCLSFHDELRY- 1043
               .|:.|: |..:|.|  |..|::......||:|                :.:|.:.:.:|:.
  Rat   766 ---LLQKDSHGSPEESRCHFRITKLGQASFKGAID----------------LTYCDTLYRDLKKG 811

  Fly  1044 ---LVKEELSPKAALAMHITNLMT 1064
               ||.|.|       :|:..|.|
  Rat   812 LEGLVLESL-------LHLVYLTT 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	9/51 (18%)
		TRH	<420..539	CDD:283171	34/157 (22%)
		DNA_pol_gammaA	705..1107	CDD:176478	70/403 (17%)
Helq	NP_001014156.2	PRK02362	273..1020	CDD:235032	133/705 (19%)
		DEAD	300..461	CDD:278688	45/229 (20%)
		HELICc	589..667	CDD:197757	17/87 (20%)
		HHH_5	967..1020	CDD:291205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900