Protein Alignment tam and Poln

DIOPT Version :9

• Sequence 1: NP_476821.1
• Gene: tam / 34792
• FlyBaseID: FBgn0004406
• Length: 1145
• Species: Drosophila melanogaster
• Sequence 2: NP_862905.1
• Gene: Poln / 272158
• MGIID: 2675617
• Length: 866
• Species: Mus musculus
• Alignment Length: 934
• Identity: 169/934 - (18%)
• Similarity: 296/934 - (31%)
• Gaps: 298/934 - (31%)

  Fly   203 STKRWY---SWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSY-- 262
            |.||.|   |..|.|.:||       ..|:.|||.......:.:...||..   |.   :|.|
Mouse   155 SLKRKYITCSKSSEKASKH-------TALEKDTDGTESWPNSRDTRALGER---LC---DVRYLG 206

  Fly   263 ------------DRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAMLKSKKEPAAEDL--- 312
                        ..|.|....:.:|..|:.....:|...|.|:.    .:|||....:...|
Mouse   207 DLAKAQLMDALKQAAALVVTLMYKDGSTQLSAKEALTCTVKGIV----VLLKSHVGNSTLTLPAH 267

  Fly   313 -GWLEQS--SLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRIL 374
             |.||:.  |.:..|.:|..:.......:|..::||...|      |.:|...|..........:
Mouse   268 GGALEKDFISEDHCVYIHTEHSPFWDPKQEAHSLFVRNIL------FWTLRCKCPVVCFNAKDFV 326

  Fly   375 RVLYPLYAE--RFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAEEA 437
            |.:..||.|  .:.|.|...|:....:|:|...|       :...::|||       :.:..|::
Mouse   327 RTVLQLYGEDGSWKHVADFVGLDPRVAAWLIDPS-------DTAPSFEDL-------VAKHLEKS 377

  Fly   438 CSLLLDDQYRQNLWLWDEDWSVQELKLKQPPKRKPLPTVELKDSGNTPEERRLQAKFQHLYDQQA 502
            .::                              ||..|  .:::......:.:....:.|||...
Mouse   378 ITV------------------------------KPSST--FREASRNTLSQNVFMNLKILYDLTM 410

  Fly   503 LLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLSLCWEGYP 567
            .|.::   |..|.||......:.|......::|:.:.|......| .|...:..:|..|..|.:.
Mouse   411 DLCSK---LKAYGLWQLFCTLELPLIPILAVMENHKIPVDKEEME-RTSALLGARLKELEQEAHF 471

  Fly   568 LHYEREQGWGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSASKAESDMAFDMLPGQVEQH-L 631
            :..|:     ||:                                 ..::...::|.|:::.| |
Mouse   472 VAGEQ-----FLI---------------------------------MSNNQLREILFGKLKLHLL 498

  Fly   632 GKREHYKKLSQKQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFL------ 690
            .:|:|..:..     |:.|...|....|.:.|                  .:||.|..|
Mouse   499 SQRKHLPRTG-----LQNQLSTSEAMLNSLQD------------------LHPLPKLILEYRQVH 540

  Fly   691 ---NKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQLPNEFTGEKCQP 752
               :.|.:.:|:           .:....:.|.| |....:.|::     |.:.|| ..|....|
Mouse   541 KIKSTFIDGLLA-----------YMKKGSISSTW-NQTGTVTGRL-----SAKHPN-IQGISKHP 587

  Fly   753 IAYGAICPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIA 817
            |                 :..:| | .......:.:....|::..:..|:..:.||....||.|.
Mouse   588 I-----------------KISKP-W-NFKGKEEETVTISPRTLFVSSEGHTFLAADFSQIELRIL 633

  Fly   818 SVLGDAYACGEHGATPLGWMTLSGSKSNGSDMHS-ITA--------KAVGISRDHAKVINYARIY 873
                 |:..|:.....|      ..:|...|:.| :|:        :...:.|:..|.:.|:.:|
Mouse   634 -----AHLSGDPELLKL------FQESERDDVFSTLTSQWKDIPIERVTHMDREQTKKVVYSVVY 687

  Fly   874 GAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGKRVYRLREEF---HDELEDRAYSSYEASR 935
            |||                    |.:......:|..:..:.| |.|   :.:::|.|
Mouse   688 GAG--------------------KERLAACLGVTVLEATHFL-ERFLQKYKKIKDFA-------- 723

  Fly   936 LAIQRNRTLAEVFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFL 1000
                  :|:....|...:.                     |..||.|  |.|......:|:.|..
Mouse   724 ------QTVIGQCHSAGYV---------------------TSILGRR--RPLPRICAQDQQLRAQ 759

  Fly  1001 PTR--INWVVQSGAVDFLHLMLVSMRWLMGSH----VRFCLSFHDELRYLVKEELSPK-AALAMH 1058
            ..|  :|:|||..|.|...|.::.:...:.:.    .|.....||||.:.|::...|: |||...
Mouse   760 AERQAVNFVVQGSAADLCKLAMIRISTAVATSPTLTARLVAQIHDELLFEVEDTQVPEFAALVRR 824

  Fly  1059 ITNLMTRSFCVSRIGLQ-DLPMSV 1081
            |...:.:   |..:.|| .:|:.|
Mouse   825 IMESLQQ---VQTLELQLQVPLKV 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	7/41 (17%)
		TRH	<420..539	CDD:283171	17/118 (14%)
		DNA_pol_gammaA	705..1107	CDD:176478	74/397 (19%)
Poln	NP_862905.1	PolA	261..854	CDD:223820	141/811 (17%)
		DnaQ_like_exo	<314..437	CDD:299142	27/171 (16%)
		DNA_pol_A_theta	444..856	CDD:176475	100/573 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900