Protein Alignment PolG1 and pog1

DIOPT Version :10

• Sequence 1: NP_476821.1
• Gene: PolG1 / 34792
• FlyBaseID: FBgn0004406
• Length: 1145
• Species: Drosophila melanogaster
• Sequence 2: NP_588025.2
• Gene: pog1 / 2539099
• PomBaseID: SPCC24B10.22
• Length: 1018
• Species: Schizosaccharomyces pombe
• Alignment Length: 1163
• Identity: 389/1163 - (33%)
• Similarity: 558/1163 - (47%)
• Gaps: 242/1163 - (20%)

  Fly     4 HLIRKYASKVSREHYASSSVKIFRRVKPPQKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQ 68
            |.|.|....:...||:|.|.                    ::|.|...  |.|.||.:|..|..|
pombe    17 HSIIKTKKFLYCRHYSSKSF--------------------IDNAPLRI--NPVGVQYLSPALQNQ 59

  Fly    69 LFPQAPRSISEQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQ 133
            :|||....||:..:..||.:   |.:|.:..:.:..:.....:||.|:|..|.|||:||..|..:
pombe    60 VFPQQNTQISQLHLDLAKFH---LAKHQLLNKETIKLPSFNFRLPPLQGKTISEHFYNIGLEFAE 121

  Fly   134 PYEELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVL 198
            |:....:...:.: .|.:||.|....|||.| .:||:.:.|.:|....:||||||........|:
pombe   122 PHLSKAIKFSKID-TPVQPKTWKRQPGWTKY-AKDGSISCVPYPDSDCMVFDVEVLYKVSPFAVV 184

  Fly   199 ATAVSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYD 263
            |||||...||.|:|..|..             .::::|      :|||....| .|.||||||:|
pombe   185 ATAVSEDAWYCWLSPWLLG-------------KSENDR------QLIPSNPKG-ALFVGHNVSFD 229

  Fly   264 RARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQ--------RAMLKSKKEPAAED--------- 311
            |.|::|:|..:.:...|:||||||:...|:.|.|        :|.::|:....:||
pombe   230 RQRIREEYNIKSSRNVFLDTMSLHVATHGMCSRQKPTWFKARKAYIRSQSTETSEDDDSSSFDDD 294

  Fly   312 -------LGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEA 369
                   ..||..||:|||.:|.:.:| ..||.|..|:.|.....|.:.|....|..|||.|..:
pombe   295 YQNYLKQEPWLAHSSVNSLKDVAKFHC-NITLDKSKRDDFASLEKEPILQKLNELITYCAHDTYS 358

  Fly   370 THRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRA 434
            ||::.:.::|.:.|..||||:.:.||.:||.:||||.:|.|||...:..|:.:.......|.:.|
pombe   359 THQVFKKVFPQFLEVCPHPATFSAMLSLGSVFLPVNHSWTRYINGVEEQYQQMIQLVDQKLSQYA 423

  Fly   435 EEACSLL-LDDQYRQNLWLWDEDWSVQEL--KLKQPPKRKPLPTVELKDSGNTPEERRLQAKFQH 496
            |:|..|: ..|...::.||...||:...|  |||:..:..|:
pombe   424 EKAKDLINTKDTVLKDPWLRQLDWTPCNLYRKLKKATQEVPV----------------------- 465

  Fly   497 LYDQQALLPARRPLLPGYPLWYRK-LCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLS 560
                             .|.||:| .|:  ..|||                .|:...::||.||.
pombe   466 -----------------VPKWYKKAYCK--TEKRA----------------VITAKSRLAPILLR 495

  Fly   561 LCWEGYPLHYEREQGWGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSASKAESDMAFDMLPG 625
            |.|:.:||.:....||.|.|. |:..:.::.| ::|.|..|
pombe   496 LKWKKHPLAWSDTYGWVFSVE-RTSKDEIEML-LDQGLVPC------------------------ 534

  Fly   626 QVEQHLGKREHYKKLSQKQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFL 690
                   .||...||.....                     .|.|:|||:||..|.|:||||.:.
pombe   535 -------SREEDTKLDYNNY---------------------IFFKVPHKDGPEARCGSPLSKSYQ 571

  Fly   691 NKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQL--PNEFTGEKCQPI 753
            ..|.|.:|.|   ..:.|.:.::::...|||.:.||||..|||||....:|  |:...|
pombe   572 RYFEEGILQS---DYEVAKKALEMSASCSYWSSARDRIRSQMVVWDKDAELGVPSSVDG------ 627

  Fly   754 AYGAICPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIAS 818
             :|.|.|.::..||:||||:|.||:|||||:.:||||||::|::||.||..|||||||:||||.:
pombe   628 -FGIILPCIIPMGTVTRRAVENTWLTASNSKKNRLGSELKAMIRAPDGYTFVGADVDSEELWIVA 691

  Fly   819 VLGDAYACGEHGATPLGWMTLSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETL 883
            ::||: ....||||.||.|||.|.||.|:|:||.||..:|:|||.|||.||.|:||||......|
pombe   692 LMGDS-QFRLHGATALGMMTLEGKKSEGTDLHSKTAAILGVSRDSAKVFNYGRLYGAGLKHTTLL 755

  Fly   884 LRQFNPTFSASEAKAKAMKMFSITKG---KRVYRLREEFHDELEDRAYSSYEASRLAIQRNRTLA 945
            |.|.|||...:|||..|.|:::.|||   |...||:|....:|
pombe   756 LMQMNPTLKTAEAKELAKKLYASTKGVKSKMSKRLQEMGLPKL---------------------- 798

  Fly   946 EVFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQS 1010
             .|    |..||||.:||:||.:|....||||.|...:::||.:..  ..:..|:.:|:||.:||
pombe   799 -TF----WSQGTESFVFNKLEAMAQLPSPRTPVLDAGITQALSSKN--LSKNSFMTSRVNWAIQS 856

  Fly  1011 GAVDFLHLMLVSMRWLMGSH---VRFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVSRI 1072
            .|||:|||:||||..|:..:   .|..|:.|||:|||..::...:.|.|:.:.||.||:|...|:
pombe   857 SAVDYLHLLLVSMNHLIKKYYLEARLSLTVHDEVRYLSSDKDKYRVAFALQVANLWTRAFFCQRL 921

  Fly  1073 GLQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEK 1130
            |:.:||.||||||||::|.||||:..|||.||||.      ..|.||:.|::...:||
pombe   922 GINELPQSVAFFSSVDIDHVLRKDVKMDCVTPSNK------VPIPPGEELTIESVLEK 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolG1	NP_476821.1	DNApol_Exo	107..381	CDD:465664	96/297 (32%)
		DNA_pol_A	398..>440	CDD:470638	15/41 (37%)
		DNA_pol_gammaA	705..1107	CDD:176478	181/409 (44%)
pog1	NP_588025.2	DNApol_Exo	94..370	CDD:465664	96/298 (32%)
		DNA_pol_gammaA	565..956	CDD:176478	189/430 (44%)