Protein Alignment PolG1 and HELQ

DIOPT Version :10

• Sequence 1: NP_476821.1
• Gene: PolG1 / 34792
• FlyBaseID: FBgn0004406
• Length: 1145
• Species: Drosophila melanogaster
• Sequence 2: NP_598375.3
• Gene: HELQ / 113510
• HGNCID: 18536
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 111/559 - (19%)
• Similarity: 187/559 - (33%)
• Gaps: 165/559 - (29%)

  Fly    42 ENVENGPTEYAENLVKVQMISRNLHAQLFPQAPRSISEQ----QVASAKV--YKDELRRHGV-DI 99
            ||::|...:..::.:|.:....:.|..:..:.|.:..||    ..:|:||  ..|..||..: |.
Human   204 ENLQNSSNDLGDHSMKERDWKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDH 268

  Fly   100 ESSAPVSDVQLKLP------ALRGANIEEHFHNIAKEQVQPYEELLLPLVQCEQLPKRPK----- 153
            ..:|...:.:.:.|      .|:...:.|.. |:||:.|:.....|.|..   .||.:.:
Human   269 LKNAMTGNAKAQTPIFSRSKQLKDTLLSEEI-NVAKKTVESSSNDLGPFY---SLPSKVRDLYAQ 329

  Fly   154 --------RWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEV-------CVSEGQAPVLATAVS 203
                    .|. ||..|....::........|...|.....|:       |..:....:|.....
Human   330 FKGIEKLYEWQ-HTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAI 393

  Fly   204 TKRWYSWVSS-------------------KLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGT 249
            .:...|.:||                   ..||.|   || :.|.:.| .|:.|...:.||..|.
Human   394 VQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRR---EK-KSLYIAT-IEKGHSLVNSLIETGR 453

  Fly   250 TGP-GLVVGHNVSYDRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAMLKSK---KEPAAE 310
            ... ||||                        ||  .|||...|.......|..:|   .....:
Human   454 IDSLGLVV------------------------VD--ELHMIGEGSRGATLEMTLAKILYTSKTTQ 492

  Fly   311 DLGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNI------FVEGTLEQV------RQSFQSLTNYC 363
            .:|.  .::||::.::.: :...:..:.:.|.:      .:..|:.:|      ..:|..|.||.
Human   493 IIGM--SATLNNVEDLQK-FLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYK 554

  Fly   364 ASD----VEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSI 424
            .||    ::..|     |..|..|..|:.:.|        .:.|...|.|..   |::..:.||
Human   555 YSDTLKKMDPDH-----LVALVTEVIPNYSCL--------VFCPSKKNCENV---AEMICKFLS- 602

  Fly   425 EAKYHLGRRAEEACSLL--LDDQYRQNLWLWDEDWSVQELKLKQPPKRKPLP-TVELKDSGNTPE 486
              |.:|..:.:|.|.::  |.:....||.               |..::.:| .|....||.|.:
Human   603 --KEYLKHKEKEKCEVIKNLKNIGNGNLC---------------PVLKRTIPFGVAYHHSGLTSD 650

  Fly   487 ERRLQAKFQHLYDQQAL--------------LPARRPLL 511
            ||:|   .:..|....|              |||||.:|
Human   651 ERKL---LEEAYSTGVLCLFTCTSTLAAGVNLPARRVIL 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolG1	NP_476821.1	DNApol_Exo	107..381	CDD:465664	61/338 (18%)
		DNA_pol_A	398..>440	CDD:470638	10/41 (24%)
		DNA_pol_gammaA	705..1107	CDD:176478
HELQ	NP_598375.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..261		9/48 (19%)
		BRR2	319..887	CDD:440817	86/440 (20%)
		DEXHc_POLQ-like	319..521	CDD:350784	41/236 (17%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	463..466		1/4 (25%)
		HHH_5	1013..1066	CDD:434010