DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PolG1 and POLQ

DIOPT Version :10

Sequence 1:NP_476821.1 Gene:PolG1 / 34792 FlyBaseID:FBgn0004406 Length:1145 Species:Drosophila melanogaster
Sequence 2:NP_955452.3 Gene:POLQ / 10721 HGNCID:9186 Length:2590 Species:Homo sapiens


Alignment Length:1343 Identity:257/1343 - (19%)
Similarity:399/1343 - (29%) Gaps:449/1343 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 QKVNKPKKPENVENG--PTEYAENLVKVQMISRN------------LHAQLFPQAPRSISEQQVA 83
            :|:.:....||.:.|  .|..|..:::..::.:|            ..|:..|.....|....:.
Human  1329 EKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLK 1393

  Fly    84 SAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQV-----------QPY-- 135
            :....|.....|||||  ..|.|.: ...|.|    :||:...:.|.:|           |.|  
Human  1394 TVGTMKQSSDSHGVDI--LTPESPI-FHSPIL----LEENGLFLKKNEVSVTDSQLNSFLQGYQT 1451

  Fly   136 EELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHP---LEKGLVFDV---EVCVSEGQ 194
            :|.:.|::......:.|      ||      .:|...||...   :...|:||.   :..|.| |
Human  1452 QETVKPVILLIPQKRTP------TG------VEGECLPVPETSLNMSDSLLFDSFSDDYLVKE-Q 1503

  Fly   195 AP------VLATAVSTKRW------------YSWVSSKLTKHR------------------LSVE 223
            .|      .|.:.|::..:            .|.|:.....|:                  ..||
Human  1504 LPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVE 1568

  Fly   224 KLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYDRA----RLKEQYLTEDTGTRFVDTM 284
            .|:.:|:....|:.| |......|..:.|.|...|....|..    |.::..|   ||||     
Human  1569 ALDNVDIFPVQEKNH-TVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL---TGTR----- 1624

  Fly   285 SLHMCVSGVTSYQ-----RAMLKSKKEPAAEDLGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNIF 344
            ..|..:....|:.     :.:|.....|       ||...|.|:..........:|...|.:.:.
Human  1625 QNHSFIWSGASFDLSPGLQRILDKVSSP-------LENEKLKSMTINFSSLNRKNTELNEEQEVI 1682

  Fly   345 VEGTLEQVRQSFQSLTNYCASDVE-----ATHRILRVLYPLYAERF----------PHPASLAGM 394
            .....:||:....|..|...|.:|     |.|.....|.|......          |.|.|.:.:
Human  1683 SNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKL 1747

  Fly   395 LEMGSAYLPVNSNW---------ERYI--REAQLTYEDLS-------------IEAKYHL----- 430
            ...|....|||. |         |.|:  ..:.:...|||             .:..:.|     
Human  1748 TFPGILETPVNP-WKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQD 1811

  Fly   431 GRRAEEACS-----LLLDDQYRQNL-------WLWDEDWSV-------------------QELKL 464
            |.:...|.|     .::|....|||       |...:.:|:                   ...|.
Human  1812 GLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQ 1876

  Fly   465 KQPPKRKPL-----PTVELKDS----------GNTPEERRLQAKFQHLYDQQALLPARRPLL-PG 513
            ...|:..|:     |.....|:          |.......||.:.:|.....:|:|   |.| |.
Human  1877 ASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVP---PSLDPS 1938

  Fly   514 YPL----WYRKLC-RKPPAKRADEILEDDEEPWSPGASEISTGMQIA-----PKLLSLCWEGYP- 567
            ..|    ||.:.| ||...|....::.|..:.:.  ...:|.|:.:.     ||:  .||...| 
Human  1939 LTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYK--ILLLSCGISLEQSYEDPKV--ACWLLDPD 1999

  Fly   568 -----LH----------------YEREQGWGFL-VPFRSDSEGVDRLPMEQLLAHCPVPEFARLS 610
                 ||                .|..||...| :...|:..|..|..:|.:|....:.:...|.
Human  2000 SQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLL 2064

  Fly   611 ASKAESDMAFDM-LPGQ----------VEQHLGKREHYKKLSQ-KQQRLETQ-YQGSG-----VW 657
            ..:...|:...: :|.|          :.....:.|..|.:.| |...:||| ||.:|     ..
Human  2065 QKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTS 2129

  Fly   658 CNKVLDDCCFFLKLPHK--------------------NGPSFRVGNPL--SKDFLNKFAENVLSS 700
            .:.:.:.....||||..                    ||...|:|...  |||.|||     |.:
Human  2130 SDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNK-----LKA 2189

  Fly   701 GDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQLPNEFTG-EKCQPI-----AYGAIC 759
            ..|          :..::..||...:.|. ::|..|..::..|.|.| |:..|:     |.|.|.
Human  2190 LHP----------LPGLILEWRRITNAIT-KVVFPLQREKCLNPFLGMERIYPVSQSHTATGRIT 2243

  Fly   760 --------------------------PQVVACGTLTRR--------AMEPTWMTASNSR-PDR-- 787
                                      .|.|..|.|...        ::.|........| .||  
Human  2244 FTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGM 2308

  Fly   788 -LGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGS--KSNGSDM 849
             ....:|......||..::.||....||.|.:.|       .|....:..:.....  :|..::.
Human  2309 PFSISMRHAFVPFPGGSILAADYSQLELRILAHL-------SHDRRLIQVLNTGADVFRSIAAEW 2366

  Fly   850 HSITAKAVGIS-RDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGKRVY 913
            ..|..::||.. |..||.|.|..|||.|                     ||:             
Human  2367 KMIEPESVGDDLRQQAKQICYGIIYGMG---------------------AKS------------- 2397

  Fly   914 RLREEFHDELEDRA--YSSYEASRLAIQRNRTLAEVFHRPNWQGGTESAMFNRLEEIATGSQPRT 976
             |.|:...:..|.|  ..|:::....|  |:.:.|........|..::.:..|  ....|.:...
Human  2398 -LGEQMGIKENDAACYIDSFKSRYTGI--NQFMTETVKNCKRDGFVQTILGRR--RYLPGIKDNN 2457

  Fly   977 PFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSGAVDFLHLMLVSM------------------ 1023
            |:......|                ..||.:||..|.|.:.:..|::                  
Human  2458 PYRKAHAER----------------QAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHRE 2506

  Fly  1024 -------------RWLMGSH--VR---FCLSFHDELRYLVKEE 1048
                         |.|.|..  :|   |.|..||||.|.|.||
Human  2507 GMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEE 2549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PolG1NP_476821.1 DNApol_Exo 107..381 CDD:465664 66/342 (19%)
DNA_pol_A 398..>440 CDD:470638 14/75 (19%)
DNA_pol_gammaA 705..1107 CDD:176478 80/429 (19%)
POLQNP_955452.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BRR2 76..661 CDD:440817
Helicase activity. /evidence=ECO:0000305 102..554
DEAH box 216..219
Interaction with RAD51. /evidence=ECO:0000269|PubMed:25642963 847..894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1060
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1622 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 3/19 (16%)
DnaQ_like_exo 1900..2085 CDD:447876 39/191 (20%)
DNA_pol_A_theta 2091..2585 CDD:176475 106/537 (20%)
DNA polymerase activity. /evidence=ECO:0000305 2097..2584 106/531 (20%)
Loop 1. /evidence=ECO:0000269|PubMed:21050863 2142..2177 7/34 (21%)
Loop 2. /evidence=ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:25643323 2257..2322 9/64 (14%)
Loop 3. /evidence=ECO:0000269|PubMed:21050863 2491..2535 4/43 (9%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.